Sentences with phrase «system cells lead»

The adaptive immune system is a more advanced, sophisticated part of the immune system, and miscommunications between adaptive immune system cells lead those cells to fight your body's own tissues, creating the villous atrophy seen in celiac disease.

Not exact matches

The wrong set of changes to a single cell's genetic code, combined with other system breakdowns, can lead to cancer.

«We suspected that the young are most vulnerable because of their immature immune systems, but we didn't have a lot of hard evidence to show that before,» said study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in human cells.

Mississauga, Ontario - headquartered Hydrogenics Corporation, a leading developer and manufacturer of hydrogen generation technology and hydrogen fuel cell systems, today announced that it has received an order valued at C$ 7.8 million to supply fuel cell power systems for zero - emission vehicles in China.

Even if such study leads us to something comparatively unromantic or unexciting, like «electrons, or the organic chemistry of the living cell, or the autonomic nervous system or the sun or anything else, then the workable idea of God would say: Lo, this is God.

As Birch notes, what is required physiologically for consciousness to emerge is a specialization of cells leading to a central nervous system with sense organs oriented to messages from the external world.

According to a team of researchers led by Dr. Michael Julius, a specific protein in breast milk, CD14, helps jump start an infant's immune system and develop essential B cells, which are instrumental in the development of antibodies.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

A group of the nation's leading cancer research scientists and their Cuban counterparts are exploring how to advance cancer therapy, diagnosis, and prevention, including the use of immunotherapy to harness the body's immune systems to attack and eliminate cancer cells.

If scientists «start too early to specialize in biomaterials, there is a risk that they... would know all the possible applications but they will maybe not have the basis to be able to develop new ideas or new systems,» says Christine Dupont - Gillain, who leads the Nanostructured Surfaces for Cell Engineering group at the Institute of Condensed Matter and Nanosciences of the Université Catholique de Louvain in Belgium.

We believe that they will also lead to the development of a whole new range of therapies for neurodegenerative diseases of the central nervous system,» explains corresponding author of the study Jihwan Song, professor and director of Neural Regeneration and Therapy Group at the CHA Stem Cell Institute of CHA University.

George Klinman, an FDA immunologist and lead author of the report, speculates that dangling the protein in front of the immune system in an unusual setting — on a muscle cell — might be what triggers the inappropriate response.

Activation of these receptors led to a «massive mobilisation» of myeloid - derived suppressor cells (MDSCs), which play a crucial role in lowering the immune system response back down to normal levels (European Journal of Immunology, DOI: 10.1002 / eji.201040667).

What's more, the studies suggest how our gut microbes make the immune system turn against nerve cells — a finding that could lead to treatments, like drugs based on microbial byproducts, that might improve the course of the disease.

«Drugs like morphine hijack the body's natural painkilling mechanisms, such as those used by endorphins, but because they act within the central nervous system, they can affect other brain cells that use similar pathways, leading to side effects such as addiction or sleepiness,» says Professor Gamper.

«The fact that glutamine addiction has mainly been investigated in cell culture systems may have overestimated the lethality of glutamine deprivation,» said Martin Eilers, University of Würzburg, who led the study together with Kempa.

To investigate this further, the research team led by Dr. Ali Önder Yildirim, Dr. Gerrit John - Schuster and Prof. Dr. Oliver Eickelberg at the CPC studied the influence of cells of the immune system on the development of COPD.

In this scenario, Bethany Huot, MSU cell and molecular biology graduate program alumna and the study's lead author, wanted to find out if plants» defense system was compromised or was pathogens» virulence enhanced?

But two cytokines — interleukin - 17 (IL - 17) and tumor necrosis factor (TNF)-- are overexpressed in psoriasis, leading the immune system to attack a person's own skin cells.

Even short - term blockages of this kind can lead to remarkable changes in the auditory system, altering the behavior and structure of nerve cells that relay information from the ear to the brain, according to a new University at Buffalo study.

«We've solved a mystery, revealing a new aspect of our innate immune system and what flu has to do to get around it,» says Nicholas Meyerson, a postdoctoral researcher in the BioFrontiers Institute and lead author of a paper published in the Nov. 8 issue of Cell Host and Microbe.

For example, a team led by Licheng Sun at KTH Royal Institute of Technology in Stockholm, Sweden, is working on a system that uses a photosensitised anode similar to those used in dye - sensitised solar cells (Chemical Communications, DOI: 10.1039 / c0cc01828g).

They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.

With regard to taste, the findings will allow researchers to create a complete map of all the genes expressed in every type of taste cell within a taste bud, leading to a better understanding of how the taste system works.

«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical School.

«This graphene system is able to detect the level of activity of an interfaced cell,» says Vikas Berry, associate professor and head of chemical engineering at UIC, who led the research along with Ankit Mehta, assistant professor of clinical neurosurgery in the UIC College of Medicine.

This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.

In a study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez - Agosto, UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection.

On the contrary, short - chain fatty acids, first and foremost propionic acid (or its salt propionate), lead to the development and propagation of regulatory cells of the immune system in the intestinal wall.

As explained by lead researcher, Dr Ferdinand von Meyenn, postdoctoral researcher in the Epigenetics research programme at the Babraham Institute and first author on the paper: «Our method establishes a reliable system that can be used to explore the early stages of epigenetic reprogramming in primordial germ cell - like cells and how this is regulated in the generation of reproductive cells.

Lead author Dr Chris Bakal, leader of the Dynamical Cell Systems Team at The Institute of Cancer Research, London, said: «The endoplasmic reticulum is the factory of our cells, creating the proteins and lipids needed for our cells to grow and proliferate.

The Nature Communications paper covers lung cancer cells; a similar phenomenon of collective invasion led by distinctive cells has been observed in breast cancer, but different genes and biochemical pathways appear to be important in each system.

In the studies led by Kanneganti, Kuriakose and colleagues first sought to identify the specific machinery that the innate immune system uses to induce cell suicide.

Lead author Aaron Allen was a PhD student in cell & systems biology at U of T when the work was done, and he was assisted by Sokolowski, fellow EEB student Ina Anreiter, and Oxford University collaborator Megan Neville, who taught Allen the technique.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systems.

The team led by John Hogenesch, PhD, a professor of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine at University of Pennsylvania and Jason DeBruyne, PhD, a former postdoctoral fellow in the Hogenesch lab and now an assistant professor at Morehouse School of Medicine in Atlanta, applied their new method to identifying other clock partners that target a multipurpose cell nucleus receptor for disposal.

«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.

The researchers hope their new paper encourages others to pursue TPV improvements — including fabrication of TPV cells on reusable substrates — that could lead to development of real - world systems at costs competitive with fossil fuels.

In the Dec. 1 issue of Science, the team from the MGH Center for Systems Biology describes a «crosstalk» between lung tumors and bone marrow, which leads to the generation of a type of immune cell that travels to the tumor and promotes its progression.

Research led by scientists at the Gladstone Institutes has identified the precise chain of molecular events in the human body that drives the death of most of the immune system's CD4 T cells as an HIV infection leads to AIDS.

New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.

In an attempt to protect the body from the spreading virus, these immune cells then commit «cellular suicide,» leading to the collapse of the immune system — and AIDS.

Professor Dianna Bowles, a plant biochemist and founding Director of CNAP, led the research with Professor Paul Kaye, the Director of CII, who developed the robust assay system involving human cells to assess the impacts of the different structures.

In a study published in the 26th of April issue of Cell Systems (advanced online 15th March), a Finnish - Swiss research team led by Dr. Markku Varjosalo from the Institute of biotechnology and University of Helsinki, report global quantitative interactomics analysis covering half of the human protein phosphatome.

To peel away at the intricate layers that govern the development of neurons, a research team led by Chaolin Zhang, PhD, Assistant Professor in Systems Biology and Biochemistry and Molecular Biophysics and Hynek Wichterle, PhD, Associate Professor in Pathology & Cell Biology, Neuroscience, and Neurology, at the Center for Motor Neuron Biology and Disease, Columbia University Medical Center, focuses on a level of molecular regulation called alternative splicing.

«Once their immune system found the correct receptor, T - cells expressing those receptors multiplied, leading to an overall reduction in the structural diversity of their T - cell receptors.»

A team led by the Hutch's Marie Bleakley and by Warren Shlomchik of the University of Pittsburgh School of Medicine in Pennsylvania removes naïve T cells from grafts with a magnetic system that uses monoclonal antibodies bound to iron beads.

Without these cells, the immune system recognizes a newly transplanted lung as harmful and mounts an attack that eventually can lead to rejection of the organ.

A new study led by Assistant Professor Stephan Gasser of the Department of Microbiology and Immunology at the National University of Singapore's Yong Loo Lin School of Medicine has identified a snitch that «reveals» cancer cells to the immune system.

After two earlier published attempts that led to early - stage embryos but not confirmed embryonic stem cells, Mitalipov and colleagues took steps to preserve a protein complex believed to help primate eggs restructure transplanted DNA, and employed a new imaging system to observe the egg's chromosomes directly instead of by staining them or using ultraviolet light, which might damage DNA.