Sentences with phrase «system dysfunction in»

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta - analysis

generalized demodicosis appears to occur more frequently in Aussies with a family history of autoimmune disease, so it is possible these diseases have some form of immune system dysfunction in common.

And there is the question of possible treatments, given the array of medical conditions including cardiovascular problems and hypertension associated with peripheral nervous system dysfunction in individuals with Down syndrome.

Fragile X syndrome, an intellectual disability disorder, has significant associations with asthma, psoriasis and viral infection, highlighting a potential immune system dysfunction in these patients.

Not exact matches

«The state and city used Katrina to wipe away the dysfunction and corruption in the school system,» Medberry says, referring to the city's charter school initiative, which largely replaced public schools with privately operated institutions after 2005.

Every day we've let the current dysfunction in the background check system continue, lives are in jeopardy.

In his 1984 book, Losing Ground, Charles Murray attacked the welfare system for tempting the poor into dysfunction.

Hexate is a known toxin that can lead to nervous system damage when consumed in large quantities, so no wonder consumption of processed soy has been related to thyroid dysfunction, increased infertility rates, hormonal disruption and even increased rates of breast cancer.

Following a ketogenic diet has been effectively shown to improve cardiovascular health, regulate the endocrine system, stabilize blood glucose levels, support weight loss, improve insulin sensitivity in people with type - 2 diabetes and even treat neurological dysfunction (8, 9).

«We treat those types of patients very simply, normally with clomiphene citrate, which is a pill that will normalize ovulation,» says Dr. Marrs, «If that doesn't work in certain cases of ovulatory dysfunction, women will take natural FSH, follicle stimulating hormone, and luteinizing hormone which are the two hormones in the pituitary gland that create ovulation within the ovarian follicle system.»

Exposure to these can lead to endocrine and immune dysfunctions or even problems in the nervous system during these developing times in their life.

Michel Odent, in his review of research on the «primal period «(the time between conception and the first birthday), concludes that interference or dysfunction at this time affects the development of our capacity to love, which is particularly vulnerable around the time of birth, being connected hormonally to the oxytocin system.3 Research by Jacobsen4 5 and Raine6 among others, suggests that contemporary tragedies such as suicide, drug addiction and violent criminality may be linked to problems in the perinatal period such as exposure to drugs, birth complications and separation or rejection from the mother.

«And we have quite a bit of dysfunction in our traditional public school system.

«Our findings contribute to a growing body of evidence that immune system dysfunction, including inflammation, may be involved in the pathophysiology of major psychiatric disorders in some individuals.

To find genetic mutations that would rescue the cells, Chen and Birsoy mimicked mitochondrial dysfunction in a haploid genetic system developed by former Whitehead Fellow Thijn Brummelkamp.

Mikovits believed that the signature of the immune system deficiencies described by Peterson, in combination with his report of lymphomas, was strongly reminiscent of the immune dysfunction, opportunistic infections, and cancers of AIDS.

«We think the pain these patients feel may be from a dysfunction in this inner ear pain system and similar to neuropathic pain,» García - Añoveros said.

«The mechanisms underlying JFK's pain were likely complex involving a combination of peripheral factors such as narrowing of the L5 - S1 disc space and dysfunction in central nervous system pain processing, or what we are coming to refer to as «centralized pain»,» Hassett says.

The pain system changes and pain is perpetuated and amplified by dysfunction in central pain processing, Hassett explains.

«Our results suggest that ongoing cytokine activation in the nervous system can contribute to the persistent symptoms of fatigue, pain, and cognitive dysfunction that patients sometimes experience despite having been treated for Lyme disease.»

We thought that LPA could be involved in linking these metabolic syndromes with dysfunctions of the nervous system» explains Professor Moreno.

«Research traces cause of organ dysfunction in Down syndrome: Scientists find overload of one gene hinders peripheral nervous system.»

The paper, to be published Dec. 14 in the journal Nature Communications, traces complex biochemical signals leading to peripheral nervous system dysfunction found in people with Down syndrome.

«Knowing this mechanism that underlies IL - 37's effect on the immune system now allows us to study IL - 37 function and perhaps dysfunction in a wide range of diseases,» says Mayumi Fujita, MD, PhD, investigator at the University of Colorado Cancer Center, associate professor in the CU School of Medicine Department of Dermatology, and the paper's senior author.

«Immune system dysfunction may occur early in Alzheimer's disease.»

«And many studies of the brain and central nervous system, using imaging, EEG and other objective measures of brain structure and function, add to the existing evidence that central nervous system dysfunction is a critical element in the disorder.

Respiratory muscle dysfunction is recognized in DMD, however a thorough assessment of nervous system control of respiratory muscles is lacking.

«It was known that acute exposure to pyrethroids could lead to immune dysfunction, and that the molecules they act on can be found in immune cells; now we need to know more about how longer - term exposure affects the immune system in a way that increases risk for Parkinson's.»

The structural analysis guides further mutagenesis and biochemical experiments in both reconstituted systems in vitro and in primary cells, to finely analyze the mechanisms that mediate macromolecular function, or lead to a pathological dysfunction.

The Division of Pulmonary Medicine deals with the breath of life in all its aspects: control of breathing; sleep disorders; obstruction to airflow in the common diseases of upper and lower airways such as croup, bronchiolitis, asthma, cystic fibrosis, and bronchopulmonary dysplasia; restriction to lung function from disorders affecting the chest wall, the musculature, the nervous system, or lung tissue itself; congenital anomalies; accidents such as inhalation of foreign bodies, hydrocarbons, or toxic gases; secondary effects of non-pulmonary system disorders such as gastrointestinal reflux, myopathy, or cardiac dysfunction; disease of the upper respiratory tract including rhinitis and sinusitis; and so on.

Recent research being presented at the meeting suggests that the sympathetic nervous system and dysfunction in a variety of autonomic processes could be to blame for orthostatic intolerance.

In principle, these homeostatic mechanisms could be harnessed to counteract cognitive decline and synaptic dysfunction in aging nervous systemIn principle, these homeostatic mechanisms could be harnessed to counteract cognitive decline and synaptic dysfunction in aging nervous systemin aging nervous systems.

Jeff describes how dysfunction in the glymphatic system could contribute to Alzheimer's disease, and how our growing knowledge in this area could be harnessed to develop new disease - modifying treatments.

Further studies present an association in women between the stress level and the activation of the vascular endothelial nitric oxide (NO) system, as well as with the carotid intima media thickness, suggesting a close link to stress induced cardiovascular dysfunction in women (99).

We take a multidisciplinary approach to explore the mechanisms and evolution of stromal - mediated immune dysfunction in the tumour microenvironment and uncouple the immunoregulatory systems governing their suppressive function.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Plenary Lecture: Neuromodulatory Pathways and Central Control of Sympathetic Activity in Hypertension and Heart Failure Frans Leenen of the University of Ottowa will cover the role of various neurotransmitters and neuromodulators in regulating the sympathetic nervous system and how dysregulation can lead to cardiovascular dysfunction and disease.

Recent data have demonstrated the participation of astrocytes on brain physiology, as well as their involvemet in the pathogenesis of some nervous system dysfunctions.

New research indicates a link between certain kinds of early stress and dysfunction in the neuroendocrine system...

The included birth defects were based primarily on case reports of outcomes occurring in association with Zika virus infection during pregnancy; there is more evidence for some of these birth defects than for others, and a causal link has not been established for all.5,10,12,21 - 27 Because much of the focus to date has been on microcephaly and brain abnormalities, data were summarized in 2 mutually exclusive categories: (1) brain abnormalities with or without microcephaly regardless of the presence of additional birth defects and (2) neural tube defects and other early brain malformations, eye abnormalities, and other consequences of central nervous system dysfunction among those without evident brain abnormalities or microcephaly.

To summarize (and simplify) greatly, depression is a dysfunction in the communication between your brain's frontal lobe, your thinking brain, and limbic system which controls autonomic bodily functions, like breathing and heart beat, and endocrine function, particularly in response to emotional stimuli.

Researchers now believe they have found a link between «Yo - Yo Diets» and immune system dysfunction, & that they contribute to a weaker Immune System, according to study published in the Journal of the American Dietetic Associsystem dysfunction, & that they contribute to a weaker Immune System, according to study published in the Journal of the American Dietetic AssociSystem, according to study published in the Journal of the American Dietetic Association.

It is characterized by severe dysfunction in different parts of the nervous system involved in movement, the senses, and involuntary (autonomic) functions.

When we activate the stress system in our body chronically — and don't give our body time to rest — we can get HPA axis dysfunction, commonly known as adrenal fatigue.

They help to balance hormonal levels and in return help rid of the awful symptoms such as lethargy, lack of endurance, slowed mental cognition, lost sexual drive, erectile dysfunction, hot flashes, poor bone density, high cholesterol levels, slow metabolism, loss of muscle, poor skin elasticity, a weak immune system, weaker eye sight, depression, lack of emotional stability and difficulty sleeping amongst many other symptoms that keep them down and out as they grow older.

If, as you're saying, most hypothyroidism stems from an immune system imbalance, could the the adrenal dysfunction in turn be the root cause of that?

When the GI system is in a state of dysfunction, the body becomes less able to fully digest and absorb the nutrients from food.

Since 70 % of our immune system surrounds the gut in GALT (Gut Associated Lymphatic Tissue) food allergies or intolerances may be to blame for immune dysfunction triggering the skin overgrowth aspects commonly associated with psoriasis.

No one recognizes that all the above chronic complaints derive from an interactive web in which dysfunction in one system is affecting the others.

Cordain then turns his attention to the premise that diets high in sodium can have adverse effects on inflammation, immuniological function and autoimmunity, citing a half dozen studies involving dysfunction of the immune system, chronic systemic inflammation and autoimmunity.