Sentences with phrase «system in human disease»

The role of this recycling and disposal system in human disease was not appreciated until Ohsumi and his colleagues»

The role of this recycling and disposal system in human disease was not appreciated until Ohsumi and his colleagues» work in the 1990s revealed the yeast genes that orchestrate the process.

Not exact matches

While most strains don't cause disease in humans, the bacteria can cause respiratory tract and heart valve infections and sexually transmitted chancre sores in those with weakened immune systems.

What it does: This bacteria is most notorious for causing severe illnesses such as tuberculosis, leprosy, and Hansen's disease, though most species of mycobacteria in nature are benign in humans, unless in cases of those who have weakened immune systems.

THE ELUSIVE LIQUID BIOPSY Intervention Track Ballroom C1 Every protein fragment, every strand of microRNA, every sentence and mis - sentence of DNA, every immune system marker, every signature of disease in the human being.

The 36 - year - old told the Times that his own asthma and food allergies triggered his interest in the ability of the human body's immune system to fight diseases.

Asserting that in our time the whole planetary system must be taken into account in planning for a humanly desirable future, he argues that the prime end must be to redirect the use of human and technological resources to overcoming the gap between the affluent nations and that much larger portion of mankind which still exists in hunger, poverty, disease, and misery.

I've read (in Scientific American I believe) recent research suggesting that H Pylori helps regulate the human immune system (for its own gain, of course, but ours too by suppressing auto - immune diseases).

Physiologic sleep studies have found that breastfed infants are more easily aroused from sleep than their formula - fed counterparts.247, 248 In addition, breastfeeding results in a decreased incidence of diarrhea, upper and lower respiratory infections, and other infectious diseases249 that are associated with an increased vulnerability to SIDS and provides overall immune system benefits from maternal antibodies and micronutrients in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.2In addition, breastfeeding results in a decreased incidence of diarrhea, upper and lower respiratory infections, and other infectious diseases249 that are associated with an increased vulnerability to SIDS and provides overall immune system benefits from maternal antibodies and micronutrients in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.2in a decreased incidence of diarrhea, upper and lower respiratory infections, and other infectious diseases249 that are associated with an increased vulnerability to SIDS and provides overall immune system benefits from maternal antibodies and micronutrients in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.2in human milk.250, 251 Exclusive breastfeeding for 6 months has been found to be more protective against infectious diseases compared with exclusive breastfeeding to 4 months of age and partial breastfeeding thereafter.249

The stocks are helping the development of new countermeasures such as drugs, vaccines and diagnostics in case smallpox should reappear, and may also allow researchers to explore the impact of smallpox on the human immune system, providing insights into other diseases such as AIDS.

«It has profound implications for our understanding of human development and physiology, and gives us a remarkable wealth of resources to examine how disturbances of this system might result in diseases such as cancer.»

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

Or perhaps the answer lies in the interplay between the immune system and human genetic variability: Studies have highlighted genes that strongly influence who is most susceptible — and who is most resistant — to HIV infection and disease.

The newly discovered vessels, which were also identified in human samples, could explain the long - standing conundrum of how the immune system manages to contribute to neurological and psychiatric disease.

Suspecting that the disease works differently in humans, whose brains are much bigger and more complex than those of lab animals, Brivanlou, along with research associates Albert Ruzo and Gist Croft, developed a cell - based human system for their research.

The disease progressed very gradually, just as it does in humans, suggesting that the hamsters could provide a useful animal model system.

While genetics play a role in the development of Lupus, a systemic autoimmune disease that can attack any organ system in the human body, so do environmental triggers, such as particulates in air pollution and ultraviolet light, explains Gaurav Gulati, MD, a physician - researcher at the University of Cincinnati (UC) College of Medicine.

The «old friends hypothesis» proposes that the human immune system can not learn to regulate itself without exposure to common pathogens like helminths that have coevolved with people and that modern hygienic practices deprive people of this necessary exposure, possibly explaining the relatively higher and more recent prevalence of immune diseases in industrialized countries like the U.S. Loke plans to continue researching helminthic therapy in people and in monkeys.

The human body's immune system remembers disease - causing pathogens and can react more quickly in case of renewed contact.

However, in several chronic human diseases such as inflammatory bowel disease (IBD), HIV / AIDS, cancer, cardiovascular disease, and diabetes, the immune system attacks these normally beneficial bacteria, resulting in chronic inflammation and contributing to disease progression.

In recent years, the study of human biology has been shaken up by discoveries of how the bacteria that live in the gut, the so - called microbiome, affect metabolism, the immune system, and disease progressioIn recent years, the study of human biology has been shaken up by discoveries of how the bacteria that live in the gut, the so - called microbiome, affect metabolism, the immune system, and disease progressioin the gut, the so - called microbiome, affect metabolism, the immune system, and disease progression.

«Many mitochondrial diseases affect more than one system in the human body,» said Kateryna Makova, professor of biology and one of the study's primary investigators.

By learning the genetic tricks that the parasite uses to evade the human immune system, we will be in a much better position to eliminate this deadly disease.»

The tricky part, he says, is finding a way to make the system sensitive enough so that it would pick up actual disease - causing agents in the event of a bioterror threat, but specific enough to be able to distinguish them from very closely related bacteria that may exist in the environment but do not lead to human disease.

Asthma is a disease of the human respiratory system in which the airways narrow, often in response to a «trigger» such as exposure to an allergen, cold air, exercise, or emotional stress.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

In his Ph.D. project, Dr. Henri Leinonen investigated functional abnormalities of the retina using mouse models of human central nervous system diseases.

This discovery plays a primordial role in understanding immune system diseases in humans.

Since this amoeba possesses an innate defense system similar to that of humans, while being genetically modifiable, the researchers can therefore carry out experiments on it in order to understand and fight genetic diseases of the immune system.

As with humans, the disease can seriously damage the reproductive system, causing infertility, abortion, inflammation of the testicles, and sterility, as well as high fevers and problems in the respiratory and digestive systems.

A TROPICAL disease that can fatally damage the heart may take hold in the human body by causing important immune system cells to commit suicide, according to a Brazilian research team.

A human protein known as prohibitin may play a significant role in infection of the nervous system by EV71, one of several viruses that can cause hand, foot, and mouth disease.

«Organ development, especially the liver, is highly conserved among vertebrates — including zebrafish — and the mutations we create in zebrafish alter embryogenesis in a manner consistent with humans, making it an ideal model system to study diseases such as Alagille syndrome.»

Ultimately, the enhanced understanding of central nervous system organization that has derived from the research of these three scientists may lead to new and more effective ways to repair diseased or damaged circuits embedded in the human brain and spinal cord.

Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.

The most advanced to date — dubbed RTS, S — tries to teach the immune system to defeat the parasite with a genetically engineered version of a protein from Plasmodium falciparum, the strain that causes the most serious disease in humans.

Mark Albers uses the olfactory system of mice and humans to help understand the early events of neurodegeneration in order to find ways to intervene early in the disease process before symptoms appear and distinguish early pathologic events from changes produced by aging.

The discovery suggests that blocking this immune system component may help reduce inflammation in human autoimmune and hyper - inflammatory diseases such as rheumatoid arthritis and Type 2 diabetes.

A total of 22 mouse mutant lines can be characterised through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

In an announcement likely to stand as one of the biggest breakthroughs in Huntington's disease since the discovery of the HD gene in 1993, Ionis and Roche today announced that the first human trial of a huntingtin - lowering drug, IONIS - HTTRx, demonstrates that it reduces mutant huntingtin in the nervous system, and is safe and well - tolerateIn an announcement likely to stand as one of the biggest breakthroughs in Huntington's disease since the discovery of the HD gene in 1993, Ionis and Roche today announced that the first human trial of a huntingtin - lowering drug, IONIS - HTTRx, demonstrates that it reduces mutant huntingtin in the nervous system, and is safe and well - toleratein Huntington's disease since the discovery of the HD gene in 1993, Ionis and Roche today announced that the first human trial of a huntingtin - lowering drug, IONIS - HTTRx, demonstrates that it reduces mutant huntingtin in the nervous system, and is safe and well - toleratein 1993, Ionis and Roche today announced that the first human trial of a huntingtin - lowering drug, IONIS - HTTRx, demonstrates that it reduces mutant huntingtin in the nervous system, and is safe and well - toleratein the nervous system, and is safe and well - tolerated.

The Cancer, Ageing and Somatic Mutation Programme encompasses three Projects that respectively cover the genomics of human cancers; functional analysis of the cancer genome using a range of in vitro and in vivo model systems; and the characterisation of somatic mutations in development and adult homeostasis in health and disease.

My goal is to contribute to the resolution of this important problem by bringing to bear recent advances in human genetics and integrative genomics and translating them in a mechanistic, systems - level understanding of disease that is rooted in human biology but also actionable from a drug development perspective.

In the paper, the researchers conducted blood tests on a few dozen people and found that the presence of pre-existing adaptive immune responses in humans to either Cas9 homolog «may hinder the safe and efficacious use of the Cas9 / gRNA system to treat disease, and may even result in significant toxicity to patients.&raquIn the paper, the researchers conducted blood tests on a few dozen people and found that the presence of pre-existing adaptive immune responses in humans to either Cas9 homolog «may hinder the safe and efficacious use of the Cas9 / gRNA system to treat disease, and may even result in significant toxicity to patients.&raquin humans to either Cas9 homolog «may hinder the safe and efficacious use of the Cas9 / gRNA system to treat disease, and may even result in significant toxicity to patients.&raquin significant toxicity to patients.»

For example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic disease models (for example in mouse) by mapping to human or other systems.

«Microbiology is coming to a point where it's extraordinarily evident that bacteria, fungi and viruses play a massive role in the development of health and disease in humans, in environmental settings and ecological systems,» said Jack Gilbert, PhD, associate professor in the Department of Ecology & Evolution at the University of Chicago.

«That shows that, indeed, the mouse is a good system to use in the study of human disease.

Our increased understanding in areas such as stem - cell biology, human immune systems, and identification of disease - specific biomarkers all have contributed significantly to that progress.

Most recently, Dr. Gringeri was the Chief Operating Officer for Amsterdam Molecular Therapeutics (AMT), a Netherlands - based company engaged in human gene therapies for orphan diseases related to metabolic disorders, liver diseases, blood diseases, and disorders of the central and peripheral nervous systems.

This human microbiome includes opportunistic pathogens, microbes that do not normally cause disease in a healthy person but can provoke an infection when the person's immune system is suppressed, a concern known to occur during spaceflight.

He and the Vereide Group grow precursors of human arterial cells, build colonies of dendritic cells (cells which can alert the rest of the immune system to the presence of a tumor), and use chick embryos to study the formation of early tissue layers for a possible future in which complex tissues, or even organs, can be grown to replace diseased, wounded, or malfunctioning ones.