Sentences with phrase «system on cancer cells»

The removal of these components might be expected to unleash an assault by the immune system on cancer cells left after surgery.

The medicines, which help unleash the immune system on cancer cells, were tested in patients with advanced lung cancer.

Not exact matches

The Parker Institute for Cancer Immunotherapy will focus on the emerging field of cancer immunotherapy, which harnesses the body's immune system to fight cancer Cancer Immunotherapy will focus on the emerging field of cancer immunotherapy, which harnesses the body's immune system to fight cancer cancer immunotherapy, which harnesses the body's immune system to fight cancer cancer cells.

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

The Napster founder and former Facebook president created the Parker Institute for Cancer Immunotherapy, which will focus on using the body's immune system to combat cancer Cancer Immunotherapy, which will focus on using the body's immune system to combat cancer cancer cells.

It's a type of cancer immunotherapy, which harnesses the body's immune system to take on cancer cells.

Moreover, in the aftermath of surgery, the immune system concentrates most of its efforts on healing the surgical wound, lowering its guard against cancer cells.

«Current therapies in clinical trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the cancer cells.

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

Dendritic cells are intelligence - gathering immune cells, gathering information on viruses, bacteria, cancer and fungi to aid the immune system in fighting disease.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

Patients with metastatic non-small cell lung cancer will always progress after chemotherapy, so most patients go on to be treated with immunotherapy, a type of therapy that uses the body's immune system to fight cancer.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

EMD Serono, Kirschbaum says, «focuses on the development of targeted cancer therapies on three therapeutic platforms: targeting the tumor cell, the tumor environment, and the immune system.»

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

So Swanton is focusing on immunotherapies — strategies that help the immune system to recognize and destroy cancer cells.

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

In the context of the current study, the researchers have developed a pre-clinical model system that specifically captures the impact of a treatment on cancer stem cells.

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

Because CTLA - 4 acts like a brake on the immune system, it prevents the body's defenses from attacking cancer cells.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

Other possible ways to attack pancreatic cancer cells focus on taking away their ability to hide from the immune system.

«These inhibitors not only target cancer cells but may also have a negative impact on the immune system and NK cells.

They tested the system on cell cultures, and then in live mice with breast cancer and mice with constricted arteries in their legs.

They work by sticking to specific proteins found on the surface of cancer cells, flagging them up to be killed by the immune system.

The team demonstrated the efficacy of the system by analyzing the metabolic conversion in liver cells of Tegafur, a chemotherapeutic pro-drug, into the toxic metabolite 5 - fluorouracil and its subsequent effect on cancer cells.

After injecting them into the bloodstream, we are able to gather them around the tumour using magnets and ensure that they don't kill the healthy cells,» explains Asst Prof Xu, who has been working on cancer diagnosis and drug delivery systems since 2004.

The new DETECTR system, created at UC Berkeley based on CRISPR - Cas12a, can analyze cells, blood, saliva, urine and stool to detect genetic mutations, cancer and antibiotic resistance as well as diagnose bacterial and viral infections.

Antibody that blocks a «do not eat» flag on cancer cells turns the immune system against all tumor types

The antigen got the attention of the immune system, and the result was some of the mouse T cells developed the ability to target a cancer that's incidence and death rates are on the rise in the United States.

Cancer cells are on the move in the bloodstream in the very early stage of pancreatic cancer, and can be detected before cancer is diagnosed, according to research by the University of Michigan Health SCancer cells are on the move in the bloodstream in the very early stage of pancreatic cancer, and can be detected before cancer is diagnosed, according to research by the University of Michigan Health Scancer, and can be detected before cancer is diagnosed, according to research by the University of Michigan Health Scancer is diagnosed, according to research by the University of Michigan Health System.

Based on empirical data obtained in cases of chronic myeloid leukemia, a myeloproliferative syndrome controlled by the immune system, and in solid tumors, we observe both the possible contribution of innate CD8 (+) T cells to cancer disease control and their susceptibility to tumor immune subversion.

Dr. Orkin's research focuses on the development and function of the blood system, the relationship between cancer and stem cells, and the mechanisms responsible for self - renewal of stem cells.

A full accounting of what is going on under the hood still remains to be accomplished, but the most plausible mechanism appears to be increased stem cell activity, while effects on cancer may involve a more active immune system - though that is only speculative theory at this point.

Researchers at Roswell Park Comprehensive Cancer Center have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer Cancer Center have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer cancer cells.

Some of them come from studies on cancer cells, which can blunt the immune system.

According to recent research, the most common solid tumors (that is, cancer that occurs as clusters of cells in or on organs, rather than in liquid form within the blood or lymphatic system) have up to 66 mutations that influence how the cancer cells operate — how fast they divide, whether they are susceptible to the signals that would normally cause a cell to die, when they detach from the main tumor to colonize another organ in the body, when and where they attach blood vessels to healthy tissues.

The rapidly evolving field is centered on utilizing a patient's own immune system to surveil, target, and eliminate cancer cells.

Once taken up by antigen - presenting cells, which help focus the immune system on an invader, the vaccine releases a factor that heightens their attention specifically to the cancer - promoting protein E7, a so - called oncoprotein that not only enables the human papillomavirus to multiply, but potentially cervical cancer cells to do the same.

Their method, called PRISM, uses a molecular barcoding system to test potential drug compounds on cancer and other cell lines at an unprecedented scale and speed.

Understanding the effects of Eph receptor mutations in cancer cells will help shed light on the role of the Eph receptor / ephrin system in cancer cell transformation, malignant progression and drug resistance.

Having discovered a genetic «key» (called P - TEFb) that is important in both cancer cell growth and immune cell differentiation, they tested the drugs on a mouse model for uveitis, an incurable eye condition in which the immune system mistakenly attacks healthy tissue leading to inflammation of the uvea (the middle layer of the eye).

In a paper published online Aug. 31, by Nature Medicine, researchers report that using a monoclonal antibody called anti-CD47, which blocks the «don't - eat - me» signal on malignant cells, to treat mice with an intact immune system provides a much more lifelike way to study and develop an immune - based cancer therapy.

By changing the mouse model they use to study how the immune system responds to cancer, a team of researchers hopes to shift the focus for one form of cancer immunotherapy back to the standard approach — relying on antigen - presenting dendritic cells — and away from the current upstart, macrophages.

Here we undertake a synthesis of central concepts for evolutionary predictions, based on examples of microbial and viral systems, cancer cell populations, and immune receptor repertoires.

JAX has particular strengths in research focused on understanding aging, behavior and addiction, computational biology, cancer, development and disease, gene expression, genetics and genomics, immunology and hematology, metabolism, microbiome, neuroscience, reproductive biology, statistical and population genetics, stem cells, systems biology, and translational medicine.

Maureen Su, MD, and colleagues report on a potential new way to fight melanoma by blocking one of the immune system's checks and balances, thus freeing immune cells to attack tumors and kill cancer cells.

Researchers at Roswell Park Cancer Institute have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer Cancer Institute have initiated a clinical trial based on a unique two - pronged strategy for arming the immune system to more effectively attack cancer cancer cells.

«These give us phytonutrients, which have many antioxidant assets that can put a stop to cell damage, which helps strengthen our immune system, prevents cancer, has a positive effect on our hormones, and improves our overall health and vitality.»