Sentences with phrase «system signaling molecules»

The genes revealed the array of immune system signaling molecules and steroid hormones taking part in the immune attack on the embryo.

Because Zika typically has trouble establishing infections in mice, the researchers used animals that were genetically altered so that they could not produce interferon, a key immune system signaling molecule, thus dampening the animals» immune response to the virus.

Not exact matches

He and his colleagues discovered many of the key molecules and signaling systems that guide nerve cells to make connections during development of the nervous system.

But when the immune system becomes activated in response to an illness or injury, glia in regions associated with pain processing seem to take on another role: They release inflammatory molecules that interact with nearby neurons to amplify pain signals.

The molecule appears to be a potent signal broadcast by an immune system under siege.

Then there's the West Palm Beach symposium, held to recruit participants for a study testing what happens when aging people get infusions of plasma (the fluid part of blood packed with signaling proteins and other molecules but no red or white cells) from young people who've taken a drug meant to activate their immune system.

But mounting evidence implicates the immune system in the overproduction of cell - signalling molecules called cytokines, which stimulate skin cells called keratinocytes to express genes that maintain an inflammatory microenvironment.

UV damage to the skin causes the immune system to recruit numerous signalling molecules — such as chemokines — and immune cells to fight infection.

But in the mid-1980s, three U.S. investigators discovered that it is a signal - transmitting molecule naturally used by the pulmonary, cardiac and other systems, a discovery that received the 1998 Nobel Prize.

Interferon - proteins are a family of cell signaling molecules that play a crucial role in the immune system's antiviral defenses.

This network includes a set of serotonin - sensitive neurons known as URX neurons, which have access to the worm circulatory system and apparently release a still - to - be-identified signaling molecule.

The variation in immune response can be largely explained by differences in the production of cytokines, the most important signalling molecules in our immune system.

They also hope to tweak the synthetic system so that it can sense and respond to signaling molecules released by other species of pathogenic bacteria, such as those responsible for cholera.

Most of his work focuses on the pharmacologic manipulation of mammalian brain circuits which use the most abundant inhibitory neurotransmitter in the central nervous system gamma - aminobutyric acid (GABA) as their chief signaling molecule.

Endocannabinoids are important endogenous signaling molecules in our body and the endocannabinoid system is thought to be one of the body's natural defense systems against injury.

These therapies use non-specific molecules that do not affect the cancer directly, but send signals that stimulate other cells of the immune system to fight against cancer cells.

Howard Hughes Medical Institute researchers have discovered how the T cell, the body's chief immune - system warrior, organizes signaling molecules that mobilize the weaponry used to attack foreign...

In addition, we employ high throughput screening (HTS), cheminformatics, and medicinal chemistry of novel small molecule reagents that aid in validating novel therapeutic approaches and in understanding the biology of signaling in the central nervous system.

Neuropeptides comprise a large class of signaling molecules which are secreted from neurons and transmit messages within the brain and across the nervous system.

Garrison is interested in a large class of signaling molecules called neuropeptides which are secreted from neurons and transmit messages within the brain and across the nervous system.

The researchers first discovered ascarosides as a signaling molecule in C. elegans, a nematode used as a model organism to study cell, developmental and nervous system biology, as well as human aging and diabetes.

In 1993, while at the Sloan - Kettering Cancer Center in New York, Rothman performed the key experiment that has forever linked his work to that of Thomas Südhof and Richard Scheller, by demonstrating that the same molecules that control this process in the nervous system, in the release of signaling molecules called neurotransmitters, are important to vesicle transport and fusion in all cell types.

He will now investigate a set of molecules called TLR agonists that act through receptors on the surfaces of innate immune cells to set off a chain reaction of molecular signaling and activation within the immune system, which includes activation of latently infected CD4 cells.

The system has multiple receptors and signaling molecules, some of which have been shown to increase in activity in very early disease stages in a mouse model of glaucoma.

«Myeloid cells including macrophages have receptors for stress signaling molecules, which allows them to respond to cues from the sympathetic nervous system,» explains Hanna.

Finally, the strategy applied here for selective delivery of MK801 can be extended to other small molecules for use in brain tissue (Tian et al., 2012), allowing for an approach that combines chemistry, molecular genetics, and neurobiology to dissect cell signaling pathways in specific cell types in the central nervous system.

Nitric oxide is a compound that acts as a signaling molecule in the vascular system, dilating blood vessels and increasing nutrient and oxygen delivery to all muscle cells.

Glutamate is the equivalent of the accelerator, and the GABA system, another signaling molecule, is the equivalent of the brakes, he explains.

During digestion, they make vitamins that are vital for life, send signals to the immune system, and make small molecules that can help your brain work.

It's a critical signaling molecule in the cardiovascular and circulatory system.

In line with its importance and similar to most hormone or signaling molecules in the human body, it has a whole system of enzymes and regulation steps which attempt to prevent testosterone levels from getting too high or too low.