Sentences with phrase «systemic administration»

«When combined with systemic administration of ganciclovir, rats with malignant glioma lived significantly longer than rats that did not receive this treatment.»

The intention is to thereby facilitate greater influx of a cytotoxic agent over a longer period of time than would occur with systemic administration of the same agent.

Long - term safety and efficacy following systemic administration of self - complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

However systemic administration of NPY will likely have undesirable side effects, especially on the cardiovascular system.

Increased irisin levels in circulation upon systemic administration can recapitulate part of the beneficial effects of exercise in the skeletal system,» said senior study author Jake Chen, D.M.D., M.D.S., Ph.D., professor and biological sciences researcher at TUSDM.

Sequential Systemic Administrations of Combretastatin A4 Phosphate and Radioiodinated Hypericin Exert Synergistic Targeted Theranostic Effects with Prolonged Survival on SCID Mice Carrying Bifocal Tumor Xenografts Junjie Li, Marlein Miranda Cona, Feng Chen, Yuanbo Feng, Lin Zhou, Guozhi Zhang, Johan Nuyts, Peter de Witte, Jian Zhang, Jie Yu, Raymond Oyen, Alfons Verbruggen, Yicheng Ni Theranostics 2013; 3 (2): 127 - 137.

Although researchers found that delivering the Isis drug directly into the brain nearly doubled survival time in a mouse model of SMA3, systemic administration in the rodents — which usually die within two weeks — has been shown to extend median survival by up to eight months.

The Melanoma Intra-Tumoral CAVATAK and Ipilimumab (MITCI) study [26] of CVA21 in combination with systemic administration of ipilimumab in patients with unresectable melanoma is being conducted at three US sites.

In addition, systemic administration of irisin increased bone formation and thickness, mimicking the effects of exercise on the mouse skeletal system.

«Exercise - induced hormone irisin linked to new mechanisms for bone metabolism: Systemic administration of irisin increases bone formation in mice, mimicking the beneficial effects of exercise on the skeletal system.»

Strikingly, systemic administration of Del -1-Fc ameliorated clinical relapse in relapsing — remitting EAE.

Observations on the systemic administration of autologous lymphokine - activated killer cells and recombinant interleukin - 2 to patients with metastatic cancer.

New research demonstrates that immune cells help to mediate, distribute, and transfer the immunomodulatory effects of mesenchymal stem cells following systemic administration

In animal models, systemic administration of LPS alone has been shown to result in neuroinflammation (45, 50).

The systemic administration of quinolones such as orbifloxacin has been shown to produce cartilage erosion of weight bearing joints and other signs of arthropathy in immature animals of various species.

In addition, high toxicity with systemic administration has precluded the use of tacrolimus in dogs for most situations in veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raised.