Sentences with phrase «systemic administration in»

Although researchers found that delivering the Isis drug directly into the brain nearly doubled survival time in a mouse model of SMA3, systemic administration in the rodents — which usually die within two weeks — has been shown to extend median survival by up to eight months.

Not exact matches

«The Administration has already begun the process to create the independent watchdog the Speaker is referring to by establishing a first - ever outside not - for - profit organization to monitor the system, advocate for the rights of people with special needs and disabilities and recommend future systemic reforms,» Introne said in the statement.

Corruption in Bulgaria remains systemic, present not only on the political stage but in the daily life of citizens who, when dealing with state administration, frequently have to resort to some form of bribery to receive needed services.

In a 2014 audit, Comptroller Tom DiNapoli examined DHCR's awarding of funds from a program, the Low Income Housing Trust Fund, and found systemic problems in its administratioIn a 2014 audit, Comptroller Tom DiNapoli examined DHCR's awarding of funds from a program, the Low Income Housing Trust Fund, and found systemic problems in its administratioin its administration.

DiNapoli's office found systemic problems in the program's administration.

«Being able to increase the responsiveness of peripheral opioid receptor systems could lead to a reduction in systemic opioid administration, thereby reducing the incidence of side effects.»

Increased irisin levels in circulation upon systemic administration can recapitulate part of the beneficial effects of exercise in the skeletal system,» said senior study author Jake Chen, D.M.D., M.D.S., Ph.D., professor and biological sciences researcher at TUSDM.

Development of a vaccination protocol for mucosal use (HZI): Parenteral administration induces systemic protective immunity but is inefficient in inducing mucosal immunity, whereas mucosal administration can improve both systemic and local vaccine efficacy on mucosal tissues.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

Last year the Food and Drug Administration approved Benlysta (belimumab), the first new treatment for systemic lupus erythematosus in more than 50 years, and Yervoy (ipilimumab), the first drug shown to prolong the lives of patients with melanoma.

Strikingly, systemic administration of Del -1-Fc ameliorated clinical relapse in relapsing — remitting EAE.

Administration of this reagent into mice bearing human AL tumors or those with systemic AA deposits resulted in marked reduction in amyloid burden with no evidence of toxicity in the animals.

This protocol is a dose escalation study of Ad - hCMV - TK and Ad - hCMV - Flt3L infused at the time of surgical resection followed by systemic oral administration of valacyclovir in addition to current standard of care with temozolomide and radiotherapy.

FDA Approved Ibrutinib for Relapsed, Refractory Marginal Zone Lymphoma: Approval for the use of ibrutinib in patients with relapsed or refractory marginal zone lymphoma was granted by the US Food and Drug Administration for those patients who require systemic therapy who were treated with at least one anti-CD20 therapy.

The Melanoma Intra-Tumoral CAVATAK and Ipilimumab (MITCI) study [26] of CVA21 in combination with systemic administration of ipilimumab in patients with unresectable melanoma is being conducted at three US sites.

In animal models, systemic administration of LPS alone has been shown to result in neuroinflammation (45, 50In animal models, systemic administration of LPS alone has been shown to result in neuroinflammation (45, 50in neuroinflammation (45, 50).

Indeed, Anderson's first year in Newark was marked by serious change — she closed six schools, reorganized her central administration team, cut 120 jobs — and marked the beginning of a deep systemic overhaul, financial and pedagogical.

Yet in his confirmation hearing, Duncan left little doubt that the administration wants to make systemic changes.

The second intellectual model for state standards and testing, referred to as «systemic reform,» was advanced by Marshall «Mike» Smith, who later became Undersecretary of Education in the Clinton Administration.

As the Executive Director of High Schools for Edison Schools and the Chief Academic Officer for Great Schools Workshop in Sacramento, CA, Patrick worked with building and district administrations in nine states to implement systemic high school reform.

But the fact that the Obama administration granted Virginia a waiver in the first place in spite of its record of obstinacy on systemic reform, along with the fact that many of the 32 other states granted waivers (along with the District of Columbia) have also set low expectations for districts and schools to improve the achievement of the poor and minority kids in their care, has put President Obama in the uncomfortable position of supporting the soft bigotry of low expectations for children — especially those who share his race and skin color.

Then there was Virginia, which was granted a waiver in June 2012 by the Obama Administration in spite of its longstanding unwillingness to embrace systemic reform as well as address the low quality of teaching and curricula provided to poor and minority children.

The simultaneously good and challenging news is that these shifts seem to require more a change of will than an increase in dollars, and can be accomplished both within the context of a broad, systemic model, or relatively simply, under the auspices of an enlightened administration and faculty.

If only the Obama administration would stop forcing states to continue some form of subgroup accountability and allow for more «race - neutral» approaches, then there could be more innovation in accountability that may further systemic reform.

Smith, a senior official in the Clinton administration's U.S. Department of Education, was a key author of the strategy of standards - based systemic reform.

As Dropout Nation has reported ad nauseam over the past four years, the administration has engaged in an exercise of shoddy policymaking that has damaged systemic reform by encouraging traditionalists in states such as Texas and California to weaken and ditch accountability altogether.

Whatever the case, Harkin and his colleagues don't seem like they are going to ask any hard questions about the efficacy of the process by which the Obama administration is granting the waivers, the consequences of the gambit on the systemic reforms needed to help all children get high - quality education, or whether the waiver gambit is legal in the first place.

Yet instead of seeking to address systemic inequities in school discipline, this administration may roll back protections for African American, Latino, and other minority students in the name of school safety.

If anything, the administration's latest moves confirm what your editor pointed out over the past seven months: That the federal government — especially the Department of Education — can no longer be trusted to play a role in advancing systemic reform.

There's also the fact that dismay among progressive Democrats over the Obama Administration's efforts on other fronts, along with administration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of syAdministration's efforts on other fronts, along with administration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of syadministration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of systemic reform.

In addition, high toxicity with systemic administration has precluded the use of tacrolimus in dogs for most situations in veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raiseIn addition, high toxicity with systemic administration has precluded the use of tacrolimus in dogs for most situations in veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raisein dogs for most situations in veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raisein veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raised.

Medications such as cephalosporins, sulfas and chloramphenicol, anti-cancer medications, methimazole in cats, systemic fungal diseases (eg histoplasmosis), worming medications (eg albendaole), endotoxemias / septacemias, estrogen administration, sertoli cell tumors and anti-fungal medication (griseofulvin) can all be responsible for a low PCV.

Mucosal administration followed by systemic vaccination can help to avoid immune exclusion, specifically in seropositive patients13

The most common way to treat ringworm in dogs is to use a combination of topical therapy (application of creams, ointments, or shampoos) and systemic therapy (administration of anti-fungal drugs by mouth).

Section 396.3 of Federal Motor Carrier Safety Administration's regulations requires commercial trucks to undergo systemic inspection, repair and maintenance, which is generally understood to mean a regular or scheduled program to keep vehicles in safe operating condition.

In finding that Askov's Charter rights were violated, the trial judge commented that the unreasonable delay was caused by a lack of institutional resources and that that those responsible for the administration of justice had known about the systemic problem for years.

In concluding that the evidence in this case should be excluded due to the presence of racism, he cited the long - lasting systemic implications for the administration of justice if society did not see the justice system as acting fairly and in accordance with the equality guarantee in the CharteIn concluding that the evidence in this case should be excluded due to the presence of racism, he cited the long - lasting systemic implications for the administration of justice if society did not see the justice system as acting fairly and in accordance with the equality guarantee in the Chartein this case should be excluded due to the presence of racism, he cited the long - lasting systemic implications for the administration of justice if society did not see the justice system as acting fairly and in accordance with the equality guarantee in the Chartein accordance with the equality guarantee in the Chartein the Charter,