Sentences with phrase «systemic administration of»

In animal models, systemic administration of LPS alone has been shown to result in neuroinflammation (45, 50).

The Melanoma Intra-Tumoral CAVATAK and Ipilimumab (MITCI) study [26] of CVA21 in combination with systemic administration of ipilimumab in patients with unresectable melanoma is being conducted at three US sites.

Observations on the systemic administration of autologous lymphokine - activated killer cells and recombinant interleukin - 2 to patients with metastatic cancer.

Long - term safety and efficacy following systemic administration of self - complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

Strikingly, systemic administration of Del -1-Fc ameliorated clinical relapse in relapsing — remitting EAE.

However systemic administration of NPY will likely have undesirable side effects, especially on the cardiovascular system.

Sequential Systemic Administrations of Combretastatin A4 Phosphate and Radioiodinated Hypericin Exert Synergistic Targeted Theranostic Effects with Prolonged Survival on SCID Mice Carrying Bifocal Tumor Xenografts Junjie Li, Marlein Miranda Cona, Feng Chen, Yuanbo Feng, Lin Zhou, Guozhi Zhang, Johan Nuyts, Peter de Witte, Jian Zhang, Jie Yu, Raymond Oyen, Alfons Verbruggen, Yicheng Ni Theranostics 2013; 3 (2): 127 - 137.

Not exact matches

«The Administration has already begun the process to create the independent watchdog the Speaker is referring to by establishing a first - ever outside not - for - profit organization to monitor the system, advocate for the rights of people with special needs and disabilities and recommend future systemic reforms,» Introne said in the statement.

Corruption in Bulgaria remains systemic, present not only on the political stage but in the daily life of citizens who, when dealing with state administration, frequently have to resort to some form of bribery to receive needed services.

In a 2014 audit, Comptroller Tom DiNapoli examined DHCR's awarding of funds from a program, the Low Income Housing Trust Fund, and found systemic problems in its administration.

The beating death of a Brooklyn toddler was an «entirely predictable result» of systemic problems with how the Administration for Children's Services investigates child - abuse complaints on nights and weekends, the New York City Department of Investigation said.

«Part of the systemic problem that has plagued MOVA over the last four administrations, quite frankly both Democrats and Republicans, is that the funding mechanism is always at the mercy of the mayor,» Ulrich said.

«Being able to increase the responsiveness of peripheral opioid receptor systems could lead to a reduction in systemic opioid administration, thereby reducing the incidence of side effects.»

Increased irisin levels in circulation upon systemic administration can recapitulate part of the beneficial effects of exercise in the skeletal system,» said senior study author Jake Chen, D.M.D., M.D.S., Ph.D., professor and biological sciences researcher at TUSDM.

Indeed, a series of recent, exciting studies have shown that the pathologic hallmarks of various PMDs, including Alzheimer's, Parkinson's, Huntington's diseases, and some forms of systemic amyloidosis, can be induced under experimental conditions by administration of tissue homogenates carrying the respective misfolded proteins (Xing et al., 2001; Lundmark et al., 2002; Meyer - Luehmann et al., 2006; Clavaguera et al., 2009; Ren et al., 2009; Eisele et al., 2010; Grad et al., 2011; Luk et al., 2012; Morales et al., 2012; Mougenot et al., 2012; Stöhr et al., 2012; Iba et al., 2013).

Development of a vaccination protocol for mucosal use (HZI): Parenteral administration induces systemic protective immunity but is inefficient in inducing mucosal immunity, whereas mucosal administration can improve both systemic and local vaccine efficacy on mucosal tissues.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons.

Last year the Food and Drug Administration approved Benlysta (belimumab), the first new treatment for systemic lupus erythematosus in more than 50 years, and Yervoy (ipilimumab), the first drug shown to prolong the lives of patients with melanoma.

Neither vaginal nor buccal administration of 800 μg misoprostol alters mucosal and systemic immune activation or the cervicovaginal microbiome: a pilot study.

The US Food and Drug Administration (FDA) recently approved the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib for the treatment of patients with relapsed or refractory marginal zone lymphoma who require systemic therapy and have had at least one prior anti-CD20 therapy.

Administration of this reagent into mice bearing human AL tumors or those with systemic AA deposits resulted in marked reduction in amyloid burden with no evidence of toxicity in the animals.

Although researchers found that delivering the Isis drug directly into the brain nearly doubled survival time in a mouse model of SMA3, systemic administration in the rodents — which usually die within two weeks — has been shown to extend median survival by up to eight months.

This protocol is a dose escalation study of Ad - hCMV - TK and Ad - hCMV - Flt3L infused at the time of surgical resection followed by systemic oral administration of valacyclovir in addition to current standard of care with temozolomide and radiotherapy.

The first alarm came from the discovery that Nephrogenic Systemic Fibrosis (NSF) was linked to the administration of Gd - CAs.

FDA Approved Ibrutinib for Relapsed, Refractory Marginal Zone Lymphoma: Approval for the use of ibrutinib in patients with relapsed or refractory marginal zone lymphoma was granted by the US Food and Drug Administration for those patients who require systemic therapy who were treated with at least one anti-CD20 therapy.

When a remedy is needed for more systemic use but oral administration is not an option, a wet remedy or pre-prepared cream can be applied to pulse points of the body, such as behind the knee or the inside of the wrist.

Indeed, Anderson's first year in Newark was marked by serious change — she closed six schools, reorganized her central administration team, cut 120 jobs — and marked the beginning of a deep systemic overhaul, financial and pedagogical.

The second intellectual model for state standards and testing, referred to as «systemic reform,» was advanced by Marshall «Mike» Smith, who later became Undersecretary of Education in the Clinton Administration.

Further enhancing NASDC's national profile was the fact that its key scale - up idea — moving from reforming individual schools to transforming entire systems — was quite similar to the idea of systemic reform that was one of the cornerstones of the Clinton administration's education policy.

As the Executive Director of High Schools for Edison Schools and the Chief Academic Officer for Great Schools Workshop in Sacramento, CA, Patrick worked with building and district administrations in nine states to implement systemic high school reform.

But the fact that the Obama administration granted Virginia a waiver in the first place in spite of its record of obstinacy on systemic reform, along with the fact that many of the 32 other states granted waivers (along with the District of Columbia) have also set low expectations for districts and schools to improve the achievement of the poor and minority kids in their care, has put President Obama in the uncomfortable position of supporting the soft bigotry of low expectations for children — especially those who share his race and skin color.

Then there was Virginia, which was granted a waiver in June 2012 by the Obama Administration in spite of its longstanding unwillingness to embrace systemic reform as well as address the low quality of teaching and curricula provided to poor and minority children.

The simultaneously good and challenging news is that these shifts seem to require more a change of will than an increase in dollars, and can be accomplished both within the context of a broad, systemic model, or relatively simply, under the auspices of an enlightened administration and faculty.

If only the Obama administration would stop forcing states to continue some form of subgroup accountability and allow for more «race - neutral» approaches, then there could be more innovation in accountability that may further systemic reform.

Smith, a senior official in the Clinton administration's U.S. Department of Education, was a key author of the strategy of standards - based systemic reform.

Her department has also taken action against various civil rights initiatives from the Obama administration such as guidance on the rights of transgender students, and her department announced it was scaling back civil rights investigations and would avoid looking into systemic issues.

As Dropout Nation has reported ad nauseam over the past four years, the administration has engaged in an exercise of shoddy policymaking that has damaged systemic reform by encouraging traditionalists in states such as Texas and California to weaken and ditch accountability altogether.

Despite clear evidence that Clinton would not continue the Obama Administration's systemic reform efforts, centrist Democrat reformers still worked tirelessly on behalf of Clinton's campaign.

Whatever the case, Harkin and his colleagues don't seem like they are going to ask any hard questions about the efficacy of the process by which the Obama administration is granting the waivers, the consequences of the gambit on the systemic reforms needed to help all children get high - quality education, or whether the waiver gambit is legal in the first place.

Yet instead of seeking to address systemic inequities in school discipline, this administration may roll back protections for African American, Latino, and other minority students in the name of school safety.

And it weakens arguments made by the administration that the waiver process will further systemic reform by getting rid of what it considers a broken law that never really was.

If anything, the administration's latest moves confirm what your editor pointed out over the past seven months: That the federal government — especially the Department of Education — can no longer be trusted to play a role in advancing systemic reform.

There's also the fact that dismay among progressive Democrats over the Obama Administration's efforts on other fronts, along with administration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of syAdministration's efforts on other fronts, along with administration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of syadministration's botched No Child waiver gambit, has given traditionalists the opening they need to win over both Hillary and congressional Republicans increasingly uninterested in any kind of systemic reform.

In addition, high toxicity with systemic administration has precluded the use of tacrolimus in dogs for most situations in veterinary medicine and concerns regarding the carcinogenic potential of tacrolimus applied to the skin have recently been raised.

It's important to remember that cats and dogs can have severe reactions to certain essential oils, either focused at the site of administration or more systemic.

Specific treatment heart disease dog includes the administration of different systemic cardiovascular drugs.

Though the cause of infection is unknown, extensive resection of soft tissues, poor soft tissue coverage, use of orthopedic implants, and administration of local and systemic chemotherapy are thought to be the contributing factors.

The most common way to treat ringworm in dogs is to use a combination of topical therapy (application of creams, ointments, or shampoos) and systemic therapy (administration of anti-fungal drugs by mouth).

Section 396.3 of Federal Motor Carrier Safety Administration's regulations requires commercial trucks to undergo systemic inspection, repair and maintenance, which is generally understood to mean a regular or scheduled program to keep vehicles in safe operating condition.