Sentences with phrase «systemic amyloidosis»
Systemic amyloidosis is a condition where abnormal proteins called amyloids build up in different organs and tissues throughout the body. These amyloids can affect the normal functioning of the organs, leading to various health problems. Full definition
NeuroPhage is initially developing drug candidates to treat Alzheimer's and Parkinson's diseases and several rare systemic amyloidosis diseases.
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In tests in nonhuman primates, the researchers found that the particles could effectively silence a gene called TTR (transthyretin), which has been implicated in diseases including senile systemic amyloidosis, familial amyloid polyneuropathy, and familial amyloid cardiomyopathy.
NeuroPhage is initially developing drug candidates to treat Alzheimer's and Parkinson's diseases, in which multiple misfolded proteins can exacerbate disease progression, and the Company is also targeting several rare systemic amyloidosis diseases.
Although there are various recognised causes of amyloidosis, familial systemic amyloidosis is well recognised in cats (although uncommon) and can have an inherited basis.
Looking at treatments possible in the next 5 years, I think that a treatment for senile systemic amyloidosis, telomerase gene therapy, and thymus rejuvenation, in addition to the anti-aging therapies that are already available, would be able to allow some of the supercentenarians (110 +) to be able to make it past 122.
Familial systemic amyloidosis was recognised in Abyssinian cats in the USA and characterised in the 1980s.
Systemic amyloidosis has also been described in domestic shorthair cats, Siamese cats and other breeds.
Lysosomal storage diseases such as Niemann - Pick disease, mucopolysaccharidosis and gangliosidosis (GM1) have been described in Siamese cats, as has systemic amyloidosis.