Sentences with phrase «systemic delivery»

Peptides in frog poisons are a molecular toxin against predators Frogs have evolved mechanisms that enable systemic delivery of toxic antimicrobial peptides (secreted in their skin), which are sufficiently fast - acting to evade predation.
Frogs have evolved mechanisms that enable systemic delivery of toxic antimicrobial peptides (secreted in their skin), which are sufficiently fast - acting to evade predation.
Bio-Alternatives provides vitamin B12 in sublingual liquid drops as this provides a much more efficient systemic delivery than pill or capsule form.
«We are hopeful that a systemic dose and delivery of gene therapy would broadly affect whole - body strength and function, and we are working on a host of projects for such systemic delivery in Pompe and other neuromuscular conditions,» said Barry Byrne, M.D., Ph.D., director of the Powell Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Institute.
«Conceptually, in vivo mRNA delivery has been around for a long time, but its therapeutic use has been limited by poor stability, immune - reactivity and problems with reproducible systemic delivery,» says Pad Chivukula, CSO at Arcturus Therapeutics.
While novel treatment opportunities for heart disease, like microRNA therapeutics, are often effective, systemic delivery induces a low cardiac exposure and can lead to undesirable effects in other tissues.
However, Hh signaling is important in so many different cell types and tissues that systemic delivery of such inhibitors may cause serious side effects.
Bio-Alternatives manufactures sublingual liquid melatonin supplement drops as this provides a much more efficient systemic delivery than pill form.
It would involve gene therapy delivered at the time of surgery and systemic delivery of the immune checkpoint inhibitors, such as through IV injection.
«Because these intra-articular spaces lack blood vessels, systemic delivery of morphogens and growth factors supporting cartilage matrix synthesis usually results in limited improvement.
Systemic delivery of TNF - related apoptosis - inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase - 1 (TIMP - 1) and prevents type 1 diabetes in nonobese diabetic mice.
Project: Systemic Delivery of a Neuroprotective Agent to Protect against Glaucomatous Cell Death in the DBA2 / J Mouse
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