Sentences with phrase «systemic disease control»

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

«Since patients are living longer with systemic disease controlled, there is likely a benefit to intensifying treatment of their brain lesions.

Not exact matches

The CDC (Centers for Disease Control and Prevention) also reports this about occupations that have a higher level of exposure to hazardous chemicals, «Dermal exposure to hazardous agents can result in a variety of occupational diseases and disorders, including occupational skin diseases (OSD) and systemic toxicity.»

Previous history of myocardial infarction within 1 year prior to study entry, uncontrolled hypertension or uncontrolled arrhythmias • Pulmonary disease (e.g. COPD, asthma, etc) that is not controlled (moderate to severe symptoms) with current medication • Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy

Molecular mechanisms leading to pDC dysregulation and persistent type I IFN signature are largely unexplored, especially in systemic sclerosis (SSc), a disease in which pDCs infiltrate fibrotic skin lesions and produce higher levels of IFNα as compared to healthy controls.

This protein complex controls the transcription of DNA and, when incorrectly regulated, has been linked to cancer, autoimmune diseases, and susceptibility to viral infections, many of which are problems directly linked to systemic inflammation.

According to him and others, «it is far more appropriate to approach this condition as a manifestation of systemic disease, and use such systemic treatments as are appropriate in aiding the body to regain control... [What is required, is] an approach to transformation - change in body, mind and spirit - which is possibly the only effective context in which to treat cancer.»

We excluded trials concerning calcium and vitamin D given together with a placebo comparator (trials were only eligible if vitamin D was given to both intervention and control groups, because vitamin D supplementation has been associated with decreased mortality17); trials in which calcium was administered in the form of dietary modification or a complex nutritional supplement; and trials in which most participants had a major systemic disease other than osteoporosis.

If there is no evidence of systemic disease, it is reasonable to presume that excessive canine flatus can be controlled nutritionally.

Maintaining control of dental disease is an important part of systemic health.

The cause of the disease is unknown and current treatments are focused on controlling the fever, alleviating the pain and treating the specific systemic signs present.

Although periodontal diseases have not been «officially» recognized as a complication of DM, the scientific evidence available indicates that poor metabolic control may increase the risk of gingivitis and periodontitis [2]; these periodontal pathologies have also been asso - ciated with diverse systemic diseases closely related to DM, such as cardiovascular diseases, obesity and metabolic syndrome [3][4].