Read the full study at «Intestinal cell damage and
systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease»
These findings reveal a state of
systemic immune activation in conjunction with a compromised intestinal epithelium affecting a subset of individuals who experience sensitivity to wheat in the absence of [celiac] disease.»
Neither vaginal nor buccal administration of 800 μg misoprostol alters mucosal and
systemic immune activation or the cervicovaginal microbiome: a pilot study.
Still, these studies suggest that it may be possible to induce local immunity without
systemic immune activation.
The researchers saw a dramatic reduction in
systemic immune activation and inflammation, and a slight reduction in viral replication, in the group given sevelamer, compared to the control.
Not exact matches
«Although the underlying mechanism leading to this increase in AMD in persons with AIDS is not yet known, it may relate to the state of chronic
immune activation and
systemic inflammation seen in these patients,» said Dr. Jabs.
Structural damage to the gut is thought to contribute to this
immune activation because of microbial translocation — the leakage of endotoxins and other microbial products across the gastrointestinal barrier and into
systemic circulation — but the precise mechanisms driving
immune activation, and ways to alleviate among HIV - infected individuals is still not clear.
The amygdala is response to peripheral
immune activation, so
systemic inflammation, such as in the gut, stimulates activity in the amygdala.
''... we propose that lifelong exposure to (exogenous and endogenous) stressors can stimulate local and
systemic adaptive responses, including
activation of the
immune system to incur «physiological inflammation.»