Past research by Olefsky and others has shown that obesity is characterized by low - grade inflammation in adipose or fat tissues and that this inflammatory state can become chronic and result
in systemic insulin resistance and diabetes.
We know the liver will turn some of this fructose into fat and if the fructose is delivered quickly enough (say in liquid form as sugar water), it likely to cause insulin resistance in the liver, which in turn might
cause systemic insulin resistance.