"Systemic toxicity" refers to the harmful effects that can happen throughout the entire body when a substance or condition enters the bloodstream and spreads, affecting various organs or systems.
Full definition
This is one of the biggest causes
of systemic toxicity that can affect any area of your body and cause premature aging and degenerative diseases.
Attacking the perennial problem of
systemic toxicity from typical chemotherapy treatments, Dartmouth investigators, led by Barjor Gimi, PhD, have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.
Liposomes, < 200 nm phospholipid vesicles, are longer retained in blood circulation and accumulate at pathological sites (tumours or inflamed tissues), leading to higher efficacy and
lower systemic toxicity compared to the free drugs they encapsulate.
The research team's findings demonstrate that the drug - laden nanoparticles — in combination with near infrared laser treatment — can effectively inhibit the growth of multidrug - resistant tumors with no
evident systemic toxicity.
The goal of localizing therapy to
avoid systemic toxicity from chemotherapy is the impetus for Gimi's vision to ultimately encapsulate a library of therapeutic cells that will take cues from their microenvironment and secrete appropriate antitumor molecules.
Inflammation - directed drug release offers «judicious use of locally injected drug» that extends the release for months while
eliminating systemic toxicity.»
«The holy grail in cancer immunotherapy is to eradicate tumors and prevent future recurrence
without systemic toxicity, and our studies have produced very promising results in mice,» Moon said.
Mitonafide showed antitumor activity both preclinically and in phase I and phase II clinical trials but failed due to
systemic toxicity issues.
However, these anthelminthics were administered orally for the treatment of nematode infections and showed mostly poor resorption and, therefore,
systemic toxicity data are frequently not available.
How chemocoxib A slows growth of these cells is not well understood, but it did not cause
systemic toxicity in the animals, suggesting that it may not harm normal cells.
If cancer reached the liver, doctors may also use hepatic artery infusion, which delivers high concentrations of cytotoxic agents directly to liver metastases with
minimal systemic toxicity.
Some ingested items, such as older pennies or lead material, can
cause systemic toxicities while others may cause regional damage to the intestinal tract itself due to compression or obstruction.
The CDC (Centers for Disease Control and Prevention) also reports this about occupations that have a higher level of exposure to hazardous chemicals, «Dermal exposure to hazardous agents can result in a variety of occupational diseases and disorders, including occupational skin diseases (OSD) and
systemic toxicity.»
Systemic toxicity for the solenopsin derivatives has not been tested, but Arbiser says systemic toxicity would not necessarily preclude use in skin diseases, citing the example of external application of botulinum toxin.
Dr. Chiu and his team have begun developing a more targeted method to deliver the chemotherapy: «The ultimate goal is to create an alternative way to deliver chemotherapy to people with neuroblastoma so we can increase the dosage of chemotherapy but, at the same time, decrease
the systemic toxicity,» he says.
«But a complementary way to give it in a targeted way — such as going directly to the tumor and giving a lot of it — can decrease
the systemic toxicity and hopefully prevent secondary malignancies.»
Our ability to detect anti-HER2 antibody at the tumor site but not in the blood of NSC - treated mice suggests that this approach could have robust localized anti-tumor effect, while minimizing
the systemic toxicity associated with traditional trastuzumab therapy.
Systemic toxicity — a side effect of extreme disruption of microbial function throughout your body; beneficial microbes in particular, allowing for overgrowth of pathogens
* These plants may cause more gastrointestinal irritation or upset (drooling, vomiting, and / or diarrhea) than others on the list but are not expected to cause
systemic toxicity (i.e. kidney, liver, or nervous system effects).
The following common ornamental and garden plants have been shown to cause
systemic toxicity or significant gastrointestinal irritation when ingested by dogs and cats.
Systemic toxicity is not expected but can cause GI upset and pose obstruction risk.