Sentences with phrase «systemic treatment of»

Systemic treatment of substance abuse: A graduate course.

This pure cell preparation is used in the systemic treatment of heart disease and other conditions such as inflammatory arthritis, autoimmune diseases and neurological disorders.

Implications of the new IASLC staging system and adenocarcinoma classification for systemic treatment of NSCLC - Eric Lim, MB, ChB, MD, MSc, FRCS (C - Th)

The meeting focused on evidence from preclinical models and patients that indicate SMN has a role outside of the CNS and the implications of these data for systemic treatment of SMA.

Not exact matches

Hopefully by filing suit and making my allegations public, I will help to ensure that Catholic Charities will finally fix the systemic problems I discovered and provide the type of medical treatment that would warrant the level of trust its patients place in it.»

Ever since you spread the news of your pregnancy, you have probably been inundated with tons of well - meaning, but often unwanted pregnancy and parenting... systemic yeast infection treatment

Various players this season, including Michael Bennett, Malcolm Jenkins, and several Cleveland Browns have sat, kneeled in prayer or raised their fist during the anthem to protest the unfair treatment of people of color by the police and the country's systemic injustices.

A baby with a systemic bacterial or yeast infection (including thrush), may also develop diaper rash so be sure to check in with doctor if you baby has a diaper rash that isn't improving in 3 to 4 days or if baby shows any other signs of illness, as these types of diaper rash may require more specialized over the counter or prescription treatments.

treatment of other infections, like acute respiratory infections, urinary tract infection, otitis media and other systemic infections which are present in many cases (2);

Draetta's team developed an in vivo platform called Patient - based In vivo Lethality to Optimize Treatment (PILOT), a technology enabling systemic identification of tumor vulnerabilities in patient - derived tumors.

«Recommendations guide physicians in treatment of systemic juvenile arthritis.»

They include treatment options for patients with and without active systemic disease, along with varying degrees of inflammation of the joint lining (synovitis), as well as recommendations for repeat TB screening for JIA patients receiving biologics.

«These results indicate strong two - way interactions between the brain and the gut that may help explain the increased incidence of systemic infections after brain trauma and allow new treatment approaches,» said the lead researcher, Alan Faden, MD, the David S. Brown Professor in Trauma in the Departments of Anesthesiology, Anatomy & Neurobiology, Psychiatry, Neurology, and Neurosurgery at UMSOM, and director of the UMSOM Shock, Trauma and Anesthesiology Research Center.

«Genome - wide analysis allowed us to identify a gene, VNN - 1, whose expression discriminated between good and poor responders to systemic corticosteroid treatment,» said Gurjit Khurana Hershey, MD, PhD, senior author and director of Asthma Research at Cincinnati Children's.

The study was a randomized phase II trial testing whether the addition of local treatment, in the form of consolidative radiation therapy, to the standard treatment of systemic therapy improved progression - free survival for patients with limited metastatic NSCLC.

Research on metastatic colorectal cancer and sarcoma, however, suggests a potential benefit from adding local therapy — treatment directed specifically at the tumor cells — to the standard approach of systemic therapy.

«Additional studies are needed to see if these nanoparticles could also effectively deliver other antitumor genes for the treatment of brain tumors as well as systemic cancers.»

The technique, which is described in the study «Detection of interferon - protein reveals differential levels and cellular sources in disease» published April 18 in The Journal of Experimental Medicine, will aid the diagnosis and treatment of numerous autoimmune diseases, including systemic lupus erythematosus (SLE) and dermatomyositis.

The toxicity associated with the free - form version of the drug, he says, has prevented physicians from using the drug as a systemic treatment in people, one that can travel throughout the whole body.

«Since patients are living longer with systemic disease controlled, there is likely a benefit to intensifying treatment of their brain lesions.

These agents, called engineered cationic antimicrobial peptides (eCAPs) «may be applicable to treatment of other respiratory infections, topical infections, and systemic infections,» says Montelaro.

Dr. Jabs and colleagues note that further exploration of these findings may provide the opportunity to better understand the roles of immunosenescence and systemic inflammation in the development of AMD, which in turn could lead new treatments.

Attacking the perennial problem of systemic toxicity from typical chemotherapy treatments, Dartmouth investigators, led by Barjor Gimi, PhD, have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.

The researchers found that the addition of vitamin D3 to ciclesonide did not significantly reduce the rate of first treatment failure (a composite outcome of decline in lung function and increases in use of beta - agonists, systemic steroids, and health care utilization) compared with placebo; 28 percent and 29 percent of participants in each group, respectively, experienced at least 1 treatment failure during 28 weeks.

«Systemic treatment for hepatocellular carcinoma has long consisted of just one agent — sorafenib - which was shown to provide a significant improvement in life expectancy almost 10 years ago, but no other agent has surpassed its benefits,» said the study's principal investigator Dr Jordi Bruix, Head of the BCLC group at the Hospital Clínic and Scientific Director of the Network for Biomedical Research for Hepatic and Digestive Diseases (CIBEREHD).

The toxicity of some therapies, when delivered as a systemic treatment to the whole body, for example, is another obstacle.

In the current study, a number of prognostic factors such as age, stage, comorbidity, hormonal receptor and HER2 status and differences in systemic treatments (medication after surgery) were included and considered as possible explanations for the previously reported survival differences between BCT and mastectomy.

It's hoped this latest insight will lead to the widespread use of antigen - specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (MS), type 1 diabetes, Graves» disease and systemic lupus erythematosus (SLE).

«Our research shows that combination treatment with the two compounds can promote resilience against stress - mediated depression - like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,» says Jun Wang, PhD, Associate Professor of the Department of Neurology and first author on the paper.

«Linking the navigation capability with these new results would allow therapeutics to be delivered directly to a specific site of the brain, potentially improving significantly the efficacy of the treatment while avoiding systemic circulation of toxic agents that affect healthy tissues and organs,» Carret added.

Long - term goal of the project will be to visualize and manipulate tau expression also in a systemic context (organotypic slice preparations, mouse brain) by affecting the function of tau mRNA - containing neuronal granules as a potential drug target for the treatment of neurodegenerative diseases.

The FDA granted approval to Yescarta ™ (axicabtagene ciloleucel, Kite / Gilead) for the treatment of adult patients with several types of non-Hogdkin large B cell lymphoma that is refractory or has relapsed after at least two previous systemic treatments.

The majority of these women will be cured with multimodality treatments including surgery, radiation therapy and systemic drug therapies.

Looking at treatments possible in the next 5 years, I think that a treatment for senile systemic amyloidosis, telomerase gene therapy, and thymus rejuvenation, in addition to the anti-aging therapies that are already available, would be able to allow some of the supercentenarians (110 +) to be able to make it past 122.

Effective systemic therapy for the treatment of stage III melanoma has emerged.

Last year the Food and Drug Administration approved Benlysta (belimumab), the first new treatment for systemic lupus erythematosus in more than 50 years, and Yervoy (ipilimumab), the first drug shown to prolong the lives of patients with melanoma.

Brentuximab vedotin was previously approved by the FDA to treat cHL after relapse, cHL after stem cell transplant when a patient is at a high risk of relapse or progression, systemic anaplastic large cell lymphoma (ALCL) after failure of other treatment, and primary cutaneous ALCL after failure of other treatment.

Viral vectors have the main adverse effect of inducing neutralizing antibodies, while several non-viral vectors present toxic effects (e.g. respiratory system).14, 15 In an effort to deliver efficiently the necessary drug concentration to the tumor site and prevent systemic adverse effects, the concept of administering local treatment for lung cancer has been explored.

However, these anthelminthics were administered orally for the treatment of nematode infections and showed mostly poor resorption and, therefore, systemic toxicity data are frequently not available.

The US Food and Drug Administration (FDA) recently approved the oral Bruton tyrosine kinase (BTK) inhibitor ibrutinib for the treatment of patients with relapsed or refractory marginal zone lymphoma who require systemic therapy and have had at least one prior anti-CD20 therapy.

Intensive local therapy was followed by up to a year of less intense systemic treatment with cis - retinoic acid (a derivative of vitamin A) and interferon in an effort to control any microscopic tumors that had spread to distant sites from the initial cancer.

In a study involving 12 patients with bladder cancer, who also underwent prostate surgery as part of their treatment, she identified the ICOS molecule as the first immunologic marker identified in both tumor tissues and the systemic circulation that can be used as a biomarker for monitoring of anti-CTLA-4 treated patients as a possible marker of therapeutic activity.

We offer a program focused on the treatment of pediatric hypertension, as well as a combined program with our rheumatology colleagues for the treatment of patients with systemic lupus erythematosus (a chronic, inflammatory autoimmune disorder) and other combined kidney / rheumatologic conditions.

This would prevent the toxicity seen when patients are treated with systemic immune - boosting therapies and reduce the need for multiple rounds of T - cell treatment.

Direct treatment of cutaneous melanoma lesions is on a separate track from that of systemic therapies, with its rapid advances.

Preliminary analyses of the results of the first combination trials, which show higher response rates than with either agent alone, offer some optimism that these locoregional therapies will find application — as treatment for patients who can not tolerate systemic immunotherapies, to alleviate locoregional morbidity, and perhaps even to «prime» the immune system.

The HARP study showed that 80 mg of simvastatin administered acutely to patients with acute lung injury showed significant improvements in organ failure scores, suggesting that statins modulate the systemic inflammation after only a short duration of treatment [17].

Results of the multicenter Systemic Treatment Enhancement Program for Bipolar Disorder (STEP - BD) study support the notion that antidepressants like Prozac may not be appropriate for bipolar patients.

Sometimes accompanied by chills and unregulated body temperature, it can result from severe sunburn, withdrawal from systemic treatment, or another form of psoriasis that is not well controlled.

Like many patients with a severe case, she has tried just about every kind of treatment: topical creams, systemic medications, coal tar products, even tanning beds.