«All three studies are fantastic,» says Sumit Chanda,
a systems biologist at the Burnham Institute for Medical Research in San Diego, California, who headed a team that published one of the reports online 21 December in Nature.
«Not only did we see the Salmonella proteins,» says study author Josh Adkins,
a systems biologist at PNNL, «We saw a lot of them and hints of new biology.»
«I like mentoring,» says Michael Stumpf,
a systems biologist at Imperial College London in the UK, who also indicated in the survey he spends over 20 percent of his time mentoring postdocs.
In 2011, James Collins,
a systems biologist at the Howard Hughes Medical Institute, found that some bacteria unfazed by antibiotics are actually just less metabolically active than their sensitive counterparts and aren't energized enough to ingest the drugs.
The finding that luck plays a big role in citations makes sense to Lucas Carey,
a systems biologist at Pompeu Fabra University in Barcelona, Spain, who was not involved with the study.
Andrew Murray,
a systems biologist at Harvard University, applauded the choice.
The next hurdle becomes how to get these different simulations to talk to one another, says Amy Marshall - Colón, a plant
systems biologist at Illinois who leads a lab group independent of Long's and Zhu's.
The Massachusetts team, led by Peng Yin,
a systems biologist at Harvard University's Wyss Institute in Boston, modified the DNA brick approach, which they invented, to make larger, more complex structures.
Peng Yin,
a systems biologist at Harvard University, who was not involved in the new research, says he is impressed by the work and calls it «an important advance for molecular programming, dynamic DNA nanotechnology and in vitro synthetic biology.»
Not exact matches
Kraus is a
biologist who studies the auditory
system, which is
at the nexus of our cognitive, sensory and limbic
systems.
Systems biologists, physicists, and engineers have intensively worked
at computational tools to analyze, predict, and optimize the effects of Deep Brain Stimulation (DBS) to treat chronic neurological diseases.
This limited set of nervous -
system building blocks should have restricted their ability to develop advanced intelligence, says Daniel Rokhsar, an evolutionary
biologist at the Okinawa Institute of Science and Technology Graduate University in Japan.
In flies and mice, «their robustness comes in their genetics, and in particular the ability to rapidly develop
systems where we can alter genes,» explains Jonathan Gitlin, a developmental
biologist and director of research
at MBL.
By chemically removing the gut microbiome in zebrafish in the lab and then repopulating the gut with two to three bacterial species, University of Oregon
biologist Karen Guillemin has shown that certain microbes are especially skilled
at suppressing the host immune
system and preventing inflammation — a discovery she thinks may have implications for human health.
Biologists, physicists, mathematicians, and computer scientists have begun cooperating on a sophisticated «
systems biology» aimed
at understanding how the countless molecular interactions
at the heart of life fit together in the workings of cells, organs, and whole animals.
«In the way that molecular biology dominated the last half - century,
systems biology will dominate the next half - century,» predicts French systems biologist Nicolas Le Novère, a group leader at the European Bioinformatics Institute (EBI) in Hinxton, U.K. «Systems biology is here to stay.
systems biology will dominate the next half - century,» predicts French
systems biologist Nicolas Le Novère, a group leader at the European Bioinformatics Institute (EBI) in Hinxton, U.K. «Systems biology is here to stay.
systems biologist Nicolas Le Novère, a group leader
at the European Bioinformatics Institute (EBI) in Hinxton, U.K. «
Systems biology is here to stay.
Systems biology is here to stay.»
The
systems biologists proposed that —
at least sometimes — circRNAs serve gene regulation.
For the current paper in Science, the
systems biologists teamed up with Carmen Birchmeier's lab
at the MDC to reconsider Cdr1as.
Meanwhile, Floyd Reed, a
biologist at the University of Hawai'i
at Mnoa, has been working on a different kind of drive
system called underdominance to prevent the Culex mosquitoes introduced to Hawaii from spreading avian malaria to endangered birds, including the Hawaiian honeycreeper.
Biologist Steven Jansen,
at the University of Ulm, Germany, and colleagues analysed existing data on the water transportation
systems of 226 plant species from 81 forests globally (Nature, DOI: 10.1038 / nature11688).
The research identifies a potent mechanism — rapid evolution of the reproductive
system — involved in speciation, says William Rice, an evolutionary
biologist at the University of California, Santa Barbara.
The study opens a new door to cetacean researchers, who now have a «new sensory
system» to explore, says Paul Nachtigall, a sensory
biologist at the University of Hawaii, Manoa.
These experiments will help
biologists understand how plants respond to microgravity, which will improve efforts aimed
at growing food in space — a crucial component of long - duration missions to Mars or elsewhere in the solar
system.
Neuroscientist Ratnesh Lal, an associate research
biologist on soft money
at the UC Santa Barbara Neuroscience Research Institute, compares the academic culture to the caste
system in his native India, with soft - money researchers trapped
at the bottom.
Jeff Smith, a first - year postdoc
at OISB who studies cell signaling using proteomics, notes that with no specific categories for
systems biology on research - grant applications, he has no choice but to place himself in direct competition with biochemists and
biologists in other fields.
Biologists at Johannes Gutenberg University Mainz (JGU) have now discovered that the phases of quiescence in the Drosophila fruit fly central nervous
system are controlled by the Hippo signaling pathway.
«The origins of communication signals have long fascinated evolutionary
biologists, and multiple potential mechanisms for these origins have been proposed,» says co-lead author Hannah ter Hofstede, an assistant professor
at Dartmouth who investigates how sensory
systems evolve to encode the environmental cues that are crucial for an animal's survival and reproduction.
Here are just a few of the dishes Deines, now a postdoctoral associate
at the Michigan State University Center for
Systems Integration and Sustainability, and some of his fellow
biologists cooked up to take a bite out of this invasive problem.
Biologists had already observed this interaction in living
systems — a coral reef whose millions of tightly networked members could communicate data about weather over hundreds of miles and a slime mold whose millions of member cells, spread out over acres, could coalesce and take organized action for survival
at a moment's notice.
«The test assures people that their
system is in sync with everybody else's,» says Margaret Kline, a research
biologist at the US government's National Institute of Standards and Technology, which assembled the kit.
«One of the least understood aspects of this process is how the excess milk and large numbers of dead cells are removed from the mammary gland without substantial activation of the immune
system,» says Matthew Naylor, a cancer
biologist at the University of Sydney in Australia.
Biologists and physicists really do think about living
systems in very different ways and it is essential to grasp this to ensure that we develop appropriate innovative strategies to support scientists from all these fields working
at the frontier of the life sciences.
While searching for the origin of our brain,
biologists at Heidelberg University have gained new insights into the evolution of the central nervous
system (CNS) and its highly developed biological structures.
In a new study reported in Cell, an international group of plant
biologists at ITbM, Nagoya University and other research institutes, have examined the ovules of plant cells by live - imaging to reveal a novel cell - elimination
system based on an unusual cell fusion.
Some samples taken from a small net provided a significant clue, says David Lapota, a marine
biologist at the Space and Naval Warfare
Systems Command who was on board.
The
system would also have to undergo a lot of work before it can be considered for use in humans — including, perhaps, replacing E. coli with another delivery
system, says Richard Kitney, a synthetic
biologist at Imperial College London.
Because a protein in mammalian myelin called Nogo - A is known to inhibit central nervous
system axon growth in mammals, a team of researchers led by
biologist Claudia Stürmer
at the University of Konstanz in Germany wondered if fish might be missing this protein.
Systems biologists and virologists Angela Rasmussen and Michael Katze from the Katze Laboratory
at the University of Washington Department of Microbiology led the study in collaboration with the National Institutes of Health's Rocky Mountain Laboratories in Montana and University of North Carolina
at Chapel Hill.
Researchers
at Penn State University led by
biologist Gong Chen have developed an innovative technology to regenerate functional neurons after brain injury, and also in model
systems used for research on Alzheimer's disease.
At the Cancer Institute of New Jersey, a team of physician - scientists, bioinformatics specialists,
systems biologists, pathologists and a host of others meets weekly to discuss profiling results and determine therapy options.
In a field study, Diane Adams, a marine
biologist at Woods Hole Oceanographic Institution in Massachusetts, and her colleagues measured the currents near the seafloor along the East Pacific Rise, a submarine ridge south - southwest of Acapulco, Mexico, that sports many hydrothermal vent
systems.
Undoubtedly,
systems biologists — those looking
at interacting elements of life science — want to correlate the metabolome with the genome.
«What's most interesting is how the follicle cells might be sensing each other,» says Gary Struhl, a molecular
biologist at Columbia University, who works on a similar
system in flies.
«We're trying to tease apart a largely unknown area of biology,» said
systems biologist Josh Adkins and team lead
at the Department of Energy's Pacific Northwest National Laboratory.
Decisions to deregulate any wild GM plant like the eucalyptus must take into account this lack of research, said Hong Luo, a molecular
biologist at Clemson University who has developed a gene containment
system for another wild plant, turfgrass.
The Institute: brings together a wide range of scientists, including physicists, engineers, chemists,
biologists as well as HMS clinicians to address fundamental questions about the behavior and functioning of biological
systems; allows
biologists, engineers, and clinicians to potentially use such knowledge to foster applications and new technologies; and provides a way for the tool - developers (physicists, engineers, computer scientists) to work with the tool - users (
biologists, chemists, clinicians) in the early stages of scientific inquiry and encourage scientific collaboration
at the innovation stage of tool development.
Falk Schubert: Computational
Systems Biologist, 2006 - 2009 Now Policy Officer
at German Health Ministry, Bonn (Germany)
Biologists, chemists, and material scientists like those
at PNNL are collaborating to develop a
system that can be produced
at large enough scales to truly make a difference for patients.
They are missing blood vessels, immune cells and functional connections to other areas of the nervous
system,» Jürgen Knoblich, a molecular
biologist at the Institute of Molecular Biotechnology in Vienna who was not involved in the study, tells The Scientist by email.
Marine
Biologist Tom Iliffe, also from Texas A&M University
at Galveston, said: «Providing a model for the basic function of this globally - distributed ecosystem is an important contribution to coastal groundwater ecology and establishes a baseline for evaluating how sea level rise, seaside touristic development and other stressors will impact the viability of these lightless, food - poor
systems.»