Sentences with phrase «systems biology approaches»

Specifically, the authors call for systems biology approaches (using large data sets and modeling to understand complex biological systems) to fill critical knowledge gaps in understanding how Mycobacterium tuberculosis (Mtb) infection causes disease.

Specifically, the genome - wide systems biology approaches to dissect the epigenetic processes that become abnormal when aggressive prostate cancer and melanoma initiates, rather than the reductionist «gene - by - gene» classical approaches, are urgently necessary.

Using the replicative aging of the yeast Saccharomyces cerevisiae as an aging model, we will apply quantitative systems biology approaches to investigate: 1.

The symposium focuses on systems biology approaches (both experimental and computational) to study different embryonic pattern formation mechanisms and their evolution.

ISB's Connection: With a mission to tackle biological complexity, ISB has pioneered systems biology approaches that put our scientists and collaborators in a prime position to take on the challenge of demystifying the brain.

The National Institutes of Health has awarded Virginia Tech researchers a $ 2.13 million grant to develop new systems biology approaches to study cells, one of the most basic units of life.

Integrated systems biology approaches can identify gene regulatory networks, such as immune, stress and other regulatory responses, and link them with physiologic states.6 This bioinformatics approach provides an unbiased view of the immune system profile, and can be linked to changes in environmental conditions.7 These network approaches, while often applied to identifying disease profiles, can be used to identify salutary states as well, such as that which might result from intensive meditation.

Dissecting these interactions with a combination of cell - biology and systems biology approaches should allow uncovering the tissue specific control mechanisms that are defective in cancer.

The ERA - Net ERACoSysMed, collaboration on systems medicine funding to promote the implementation of systems biology approaches in clinical research and medical practice, started in January 2015 as the first ERA - Net on systems medicine under the EU Framework Programme Horizon 2020.

From correlation to causation: analysis of metabolomics data using systems biology approaches — Antonio Rosato, Metabolomics

In the research community, we've got to develop systems biology approaches, such as this one, that take a more sophisticated approach to get us where we need to be.»

New institutions around the world are gathering interdisciplinary teams of biologists, mathematicians, and computer specialists to help promote systems biology approaches.

The systems biology approach, where cross-disciplinary scientists work together as a team, can potentially make important contributions to research.

Borenstein and his team use a systems biology approach and apply sophisticated computer modeling to understand the structure, function, and dynamics of the microbiome.

But the changing world of drug safety also requires that scientists adopt a systems biology approach.

There are ongoing studies which focus on the discovery of molecular biomarkers of the VSV - ZEBOV vaccine in healthy individuals using omics - based technologies in combination with a systems biology approach,» says Ali Harandi.

By using a systems biology approach, researchers deliberately move away from the classic reductionist manner of looking at molecules in isolation to study biological systems in their entirety.

The Transcriptomics Core Facility supports a systems biology approach in vaccine development focusing on the identification of transcriptomic correlates of vaccine immunogenicity and efficacy for a range of novel and licensed vaccines using PBMC or whole - blood and BAL fluid samples.

Extending cytokine / chemokine profiling platform (UNISI): Improvement of currently available services will be particularly focused on the optimisation of cytokine profiling for vaccine relevance using a systems biology approach.

The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.

Further, none of these previous studies took a systems biology approach by examining covariation across GE patterns (versus specific gene pathways).

«Pregnancy complications are not very well understood, and we are amongst the only labs really taking a systems biology approach to this kind of research,» Alison explains.

The systems biology approach is characterised by a cycle of theory, computational modelling and experiment to quantitatively describe cells or cell processes.

The systems biology approach often involves the development of mechanistic models, such as the reconstruction of dynamic systems from the quantitative properties of their elementary building blocks.

A systems biology approach integrating genome ‐ wide genetic variation and transcriptome profiling data from participants of the Framingham Heart Study identifies key regulatory genes and gene networks underlying blood pressure control.

Founded on the belief that food can transform lives, one plate at a time, Habit is the first company to provide personalized nutrition recommendations based on a systems biology approach.

Functional medicine reflects a systems biology approach to health care: a comprehensive analysis of the manner in which all components of the human biological system interact functionally with the environment over time.

The intensive year - long instruction combined a systems biology approach to health with an in - depth concentration on root cause of disease, coupled with therapeutic dietary treatment, and stress management techniques.

She has also started her training with the Institute for Functional Medicine which teaches healthcare professionals to get to the root cause of lifestyle - driven disease through a patient - centered, systems biology approach.

Her ongoing clinical training through the Institute for Functional Medicine uses a systems biology approach when working with those who suffer from chronic and acute conditions to help them find their path to healing.

Functional medicine uses a systems biology approach, which is a study of how our body's biological systems interact functionally with environment over time.

Not exact matches

Our embrace of systems biology and our commitment to an unbiased approach are leading to novel discoveries.

It is a problem that holistic approaches to biology such as general systems theory have been most interested in, and it is the problem that prompted C. Lloyd Morgan to speculate about forms of relatedness.

Since the completion of the Human Genome Project in 2003, scientists have expanded their knowledge of how living cells work with new approaches including genomics, proteomics, and systems biology.

A biologist, Schaal was among the first plant scientists to use molecular biology - based approaches to understand evolutionary processes in plants and she has worked to advance understanding of plants» molecular systems and population genetics.

His laboratory uses a multidisciplinary approach encompassing systems biology, molecular pharmacology, biochemistry / proteomics, cell and structural biology, and computation / bioinformatics.

Over the past decade, the development of fast and affordable technologies for DNA sequencing and synthesis and a growing understanding of complex biological systems have opened the door to a new approach to biology.

In Europe, the Center for Research and Interdisciplinarity (CRI), for example, offers a 2 - year Interdisciplinary Approaches in Life Sciences master's program with a specific track in systems and synthetic biology.

The approach combined experimental synthetic biology led by Mark Isalan, now Reader in Gene Network Engineering at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular Systems Biology lab at the CRG.

Part XIV: introduction to systems biology — a new approach to understanding disease and treatment

«Understanding the biology and commonalities between trusting social relationships and the opioid system can change the way we think about treatment,» Young says, noting that neither the punitive approach of the criminal justice system nor harsh treatment tactics are likely to increase connectedness.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

It uses cutting edge approaches to understand entire systems involved in complex biology, from a cell to the central nervous system.

The Bergthaler laboratory pursues an integrative approach comprising infection models and tools of immunology, pathology and systems biology in order to dissect novel disease - relevant interactions between pathogens and the host.

Development of a gene expression assay in non-human primates: We will develop a novel sensitive assay for the characterisation of vaccination - related gene expression profiles in NHPs, using an approach that is fully harmonised with the systems biology platform.

Using synthetic biology approaches, I am engineering fluorescent organisms to monitor mechanical sensing systems in response to pressure.

Since biological systems challenge the available methods, and the necessary foundations in physics, computer science, and mathematics are often missing, the CellDevo track greatly benefits from the fundamental research in computer science, bio-image informatics, biophysics, and applied mathematics represented in the CompBio and BioPhysEng tracks and help to develop the methodological foundations for future biology in tight integration with life imaging and other experimental approaches.

Systems biology and bioinformatics approaches are also being applied to study Brucella pathogenesis and predict Brucella vaccine candidates.

The research, published in the Proceedings of the National Academy of Sciences in September 2017, uses a combination of real - world bacterial culture results and medical records from nursing home patients, and a computing approach known as systems biology.

«It validates the approach of using even very distant model systems, such as the fly, to study human biology.