Sentences with phrase «systems biology approaches with»

The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.

Not exact matches

Since the completion of the Human Genome Project in 2003, scientists have expanded their knowledge of how living cells work with new approaches including genomics, proteomics, and systems biology.

There are ongoing studies which focus on the discovery of molecular biomarkers of the VSV - ZEBOV vaccine in healthy individuals using omics - based technologies in combination with a systems biology approach,» says Ali Harandi.

In Europe, the Center for Research and Interdisciplinarity (CRI), for example, offers a 2 - year Interdisciplinary Approaches in Life Sciences master's program with a specific track in systems and synthetic biology.

The approach combined experimental synthetic biology led by Mark Isalan, now Reader in Gene Network Engineering at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular Systems Biology lab at the CRG.

Development of a gene expression assay in non-human primates: We will develop a novel sensitive assay for the characterisation of vaccination - related gene expression profiles in NHPs, using an approach that is fully harmonised with the systems biology platform.

Since biological systems challenge the available methods, and the necessary foundations in physics, computer science, and mathematics are often missing, the CellDevo track greatly benefits from the fundamental research in computer science, bio-image informatics, biophysics, and applied mathematics represented in the CompBio and BioPhysEng tracks and help to develop the methodological foundations for future biology in tight integration with life imaging and other experimental approaches.

Dissecting these interactions with a combination of cell - biology and systems biology approaches should allow uncovering the tissue specific control mechanisms that are defective in cancer.

Approaches successful in other systems, such as modeling signal transduction and synthetic biology methodologies [32] could improve future generations of detector plants by enhancing signal transmission and providing means to deal with biological «noise».

Integrated systems biology approaches can identify gene regulatory networks, such as immune, stress and other regulatory responses, and link them with physiologic states.6 This bioinformatics approach provides an unbiased view of the immune system profile, and can be linked to changes in environmental conditions.7 These network approaches, while often applied to identifying disease profiles, can be used to identify salutary states as well, such as that which might result from intensive meditation.

Students receive training with a «systems» biology approach through courses, bench work, lab discussions and publications spanning a broad range of muscle - biology questions using studies at the level of single cells, tissues, animals and humans.

Using these approaches in combination with genetics, molecular biology and biochemistry, we are studying the molecular mechanisms underlying synaptic transmission and plasticity in mammalian central nervous system.

ISB's Connection: With a mission to tackle biological complexity, ISB has pioneered systems biology approaches that put our scientists and collaborators in a prime position to take on the challenge of demystifying the brain.

Biomarkers (Rick Paules, Section Editor): This section will present a forum for innovative scientific studies that integrate genomic, proteomic and metabolomic approaches with studies of complex physiological regulatory processes to gain a systems biology insight into complex pathways and networks controlling homeostatic and pathophysiologic states.

Functional medicine reflects a systems biology approach to health care: a comprehensive analysis of the manner in which all components of the human biological system interact functionally with the environment over time.

The intensive year - long instruction combined a systems biology approach to health with an in - depth concentration on root cause of disease, coupled with therapeutic dietary treatment, and stress management techniques.

She has also started her training with the Institute for Functional Medicine which teaches healthcare professionals to get to the root cause of lifestyle - driven disease through a patient - centered, systems biology approach.

Her ongoing clinical training through the Institute for Functional Medicine uses a systems biology approach when working with those who suffer from chronic and acute conditions to help them find their path to healing.

Functional medicine uses a systems biology approach, which is a study of how our body's biological systems interact functionally with environment over time.