«We know quite a bit about the internal defense mechanisms bacteria use to evade antibiotics but we don't really know much about their physical movements across space as they adapt to survive in different environments,» said study first author and research fellow in
systems biology at HMS Michael Baym.
A native Canadian with a passion for public outreach, Mitchell did her Ph.D. in
systems biology at the University of Ottawa.
The platform Bioinformatics will also be complemented with a part for
systems biology at Chalmers University of Technology.
This could radically transform how we respond to outbreaks, but that will only happen if we agree to share our data as widely and as quickly as possible,» said Sabeti, who is also a professor of evolutionary biology and
systems biology at Harvard University.
Jordi Garcia - Ojalvo, a professor of
systems biology at the Universitat Pompeu Fabra in Barcelona, Spain, agreed.
Pamela A. Silver is professor of
systems biology at Harvard Medical School and the Daniels Fellow at the Radcliffe Institute for Advanced Study.
Several years ago, I was fortunate to be involved in the founding of the new department of
systems biology at Harvard Medical School and the systems biology graduate program.
«Synthetic biology is a new area that's really exciting to young scientists — to have things begin to work in this way is a sort of validation of the field,» says Pamela Silver, a professor of
systems biology at Harvard University Medical School and co-author of a study demonstrating one of the first synthetic restructurings of a eukaryotic cell that is described in the journal Genes & Development.
«What was really cool about this research was we've known for a long time that a lot of different transcription factors were involved, but it was hard to understand how all the pieces fit together,» said Jenny Mortimer, director of plant
systems biology at the Joint BioEnergy Division, a part of the Department of Energy.
To build a more comprehensive picture, Greenberg teamed with co-corresponding author Bernardo Sabatini, the Alice and Rodman W. Moorhead III Professor of Neurobiology at HMS, and Allon Klein, assistant professor of
systems biology at HMS.
Lead author Aaron Allen was a PhD student in cell &
systems biology at U of T when the work was done, and he was assisted by Sokolowski, fellow EEB student Ina Anreiter, and Oxford University collaborator Megan Neville, who taught Allen the technique.
Lead author Yarden Katz, a fellow at the center and in the department of
systems biology at Harvard Medical School in Boston, says they were interested in examining the relationship between NIH funding and metrics widely used to indicate scientific quality and determine career advancement, such as publication, citation, and patent counts.
These days, as assistant professor in genomics and
systems biology at Harvard University, she usually is listed last on papers that come out of her lab.
Not exact matches
Ayyadurai bases his claims on
systems biology, a computational model that looks
at biology as a whole, rather than individual components.
Cell
biology is the same way — the cell itself may be highly organized, and order increased in comparison to the raw materials which make up the cell, but when you look
at the total inputs and total outputs of all matter and energy, the overall entropy of the
system increases.
It matters when they get legislation passed
at the state level to mandate illegitimate «science» be taught in schools, such that refutes big bang cosmology, evolutionary
biology and an 11 billion year old universe / multiverse and 4.6 billion year old solar
system.
Waddington's paper in Towards a Theoretical
Biology follows on from one by Brian Goodwin («A Statistical Mechanics of Temporal Organization in Cells») in which Goodwin looks
at the question of how ordered
systems like cells, and still more macro-organisms, supervene on the movements of their constituent molecules, and how one is to close the gap between molecular
biology and cell physiology.
Whitehurst is now a science teacher in the New York City public school
system and is planning to finish his master's degree in
biology at CCNY.
The fields within
biology are further divided based on the scale
at which organisms are studied and the methods used to study them: biochemistry examines the fundamental chemistry of life; molecular
biology studies the complex interactions of
systems of biological molecules; cellular
biology examines the basic building block of all life, the cell; physiology examines the physical and chemical functions of the tissues and organ
systems of an organism; and ecology examines how various organisms interrelate.
Typically, physiologists and scientists study one
system at a time, but nutrition is a cross-cutting science with impacts across
systems biology.
Not that that's necessarily the very first way Darwinian
systems began, but
at some point they had to transition into a
system more related to modern
biology where cells are all bounded by membranes.
That means you'll need to know some math, says Richard Kitney, a biomedical
systems engineer who teaches synthetic
biology at Imperial College London (ICL) in the United Kingdom.
Not only has SynBERC set up an open - source
system for sharing DNA sequences and the basic components of synthetic
biology, but stretches of synthetic DNA can now be ordered over the Internet
at relatively low cost.
Peng Yin, a
systems biologist
at Harvard University, who was not involved in the new research, says he is impressed by the work and calls it «an important advance for molecular programming, dynamic DNA nanotechnology and in vitro synthetic
biology.»
Those ideas crystallized and became part of the so - called biolinguistic framework, which looks
at language as an element of human
biology, rather like, say, the visual
system.
Thieme works
at the interface of differential equations, integral equations, and dynamical
systems (on the one hand), and ecology, population
biology, and epidemiology (on the other).
«In
biology, we might say that an egg, a larva, a pupa and a butterfly are all the same
system seen
at different stages of development,» Shara says.
Working with colleagues
at the Center for Theoretical Biological Physics
at the University of California, San Diego, he wants to unravel what it is that makes bacteria so adept
at survival by looking
at pattern formation in complex dynamic
systems alongside the molecular
biology and biophysics of bacteria.
My cancer
systems biology team
at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.
At the same time, fields that demand multidisciplinary cooperation such as translational medicine, climate science, and
systems biology are on the rise.
«This study is an important step toward solving one of the biggest mysteries in
biology: the need to sleep,» says study leader Susan Harbison, Ph.D., an investigator in the Laboratory of
Systems Genetics
at NHLBI.
Jörg Stelling, a
systems biology group leader and assistant professor of bioinformatics
at ETH Zurich, calls it «an investment.»
The
Systems Biology Group
at the Pacific Northwest National Laboratory in Richland, Washington, employs 90 - plus staff scientists working on proteomics, microbial - cell dynamics, cell and molecular imaging and spectroscopy, computational
biology, and bioinformatics.
Biologists, physicists, mathematicians, and computer scientists have begun cooperating on a sophisticated «
systems biology» aimed
at understanding how the countless molecular interactions
at the heart of life fit together in the workings of cells, organs, and whole animals.
«In the way that molecular
biology dominated the last half - century,
systems biology will dominate the next half - century,» predicts French systems biologist Nicolas Le Novère, a group leader at the European Bioinformatics Institute (EBI) in Hinxton, U.K. «Systems biology is here to stay.
systems biology will dominate the next half - century,» predicts French
systems biologist Nicolas Le Novère, a group leader at the European Bioinformatics Institute (EBI) in Hinxton, U.K. «Systems biology is here to stay.
systems biologist Nicolas Le Novère, a group leader
at the European Bioinformatics Institute (EBI) in Hinxton, U.K. «
Systems biology is here to stay.
Systems biology is here to stay.»
BioSysBio Conference in synthetic
biology,
systems biology, and bioinformatics
at Cambridge University, on 23 - 25 March 2009
«With switchgrass, for example, frequently you can not harvest the first year's crop because it takes a long time for the root
system to establish,» says study author Philip Benfey, a professor of
biology at Duke University and director of Duke's Institute for Genome Sciences and Policy Center for
Systems Biology.
Larry Hjelmeland, a blind researcher
at the University of California, Davis, who studies the
biology of eye ageing, says that Apple's latest operating
system has made it much easier for him to read everything from e-mails to scientific papers.
Joseph Wang
at the University of California − San Diego and colleagues in Spain note that small tubular micro-machines have already proven useful in
biology, with their ability to work as receptors or drug delivery
systems.
«In a previous study focused on identification of the first cells in the nervous
system to fail during aging of this reflex we found that sensory neuron aging drives aging of the circuit, said Lynne Fieber, associate professor of marine
biology and ecology
at the UM Rosenstiel School.
The 1 - year MRes program in
systems and synthetic
biology at Imperial College London offers a stronger research focus, supporting students in the life sciences, engineering, and physical sciences for collaborative work.
His research group focuses on big data network
biology, exploring biological
systems by developing and deploying algorithms aimed to predict cell behavior, in particular looking
at cellular signal processing and decision making.
The new research recently published by scientists
at the Okinawa Institute of Science and Technology Graduate University (OIST) in the journal Soft Matter carefully examines the relationships between self - motile and passive or inert agents to determine possibility of creating fully synthetic
systems by looking into examples of
biology interacting with mechanical mechanisms.
Jeff Smith, a first - year postdoc
at OISB who studies cell signaling using proteomics, notes that with no specific categories for
systems biology on research - grant applications, he has no choice but to place himself in direct competition with biochemists and biologists in other fields.
At its core, the idea behind synthetic
biology is simple: design and build biological
systems to do what we want them to do.
«The purpose of the paper was to provide the detailed recipes and protocols so that others can easily duplicate the work and help to further permeate the idea of «building with
biology» — so that other researchers and educators can have the tools and the knowledge to build these bio-hybrid
systems and attempt to address challenges in health, medicine, and environment that we face as a society,» stated Rashid Bashir, a Grainger Distinguished Chair in Engineering and head of the Department of Bioengineering
at Illinois.
It lies
at the crossroads of computational genetics,
systems biology, information theory, and network science,» Darabos said.
The approach combined experimental synthetic
biology led by Mark Isalan, now Reader in Gene Network Engineering
at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular
Systems Biology lab
at the CRG.
«It's the first look
at how chemistry and
biology involve just a few key motions for even the most complex
systems,» says U of T chemistry and physics professor R. J. Dwayne Miller, principal investigator of the study.
Nicholas Brereton, a research fellow
at Université de Montréal's Plant
Biology Research Institute and senior author of the study, adds that «our initial mind - set was that bioinformatics and
biology could be more profoundly integrated to see the diversity of function within a challenged root
system.