Sentences with phrase «systems biology model»

Researchers in the US, China and Taiwan have developed a new systems biology model that mimics the process of wood formation, allowing scientists to predict the effects of switching on and off the 21 (at least) pathway genes involved in producing lignin, a primary component of wood.

The researchers developed algorithms to use in a «systems biology modeling cycle,» in which they repeatedly fit a model to gene expression data obtained from laboratory experiments until a good fit was obtained between the predicted and the measured outcomes.

Not exact matches

Ayyadurai bases his claims on systems biology, a computational model that looks at biology as a whole, rather than individual components.

Computer simulations have become a useful part of mathematical modelling of many natural systems in physics, chemistry and biology, human systems in economics, psychology, and social science and in the process of engineering new technology, to gain insight into the operation of those systems.

Fussenegger's group developed the genetic network; Professor of Biosystems Engineering Andreas Hierlemann and his team tested the acidity sensor with the aid of microfluidic platforms; and Jörg Stelling, a professor of computational systems biology, modelled it in order to estimate the dynamics of the insulin production.

«I wanted to do modeling of molecular biology and find out how we should put these networks of genes together conceptually to understand living systems.

The contributors offer a synthesis of nearly 50 years of research on a classic model system for population biology, the Soay sheep of Hirta.

The authors believe that these tools and methods will lay the foundation for crucial breakthroughs in the flatworm model system and in our understanding of stem cell biology and the process of regeneration.

«In our human airway epithelial model system, one of the drugs destabilizes and deactivates the protein that the other drug tries to correct,» said Martina Gentzsch, PhD, an assistant professor of cell biology and physiology and senior author of the UNC Science Translational Medicine paper.

Borenstein and his team use a systems biology approach and apply sophisticated computer modeling to understand the structure, function, and dynamics of the microbiome.

Cucumber is a major vegetable crop consumed worldwide as well as a model system for sex determination and plant vascular biology.

(Although climate models have critics, they reflect our best ability to describe how the climate system works, based on physics, chemistry and biology.

This webinar will discuss how integrated HCS imaging systems that have been coupled with novel computer modeling are being applied to systems biology, translational cancer research, and personalized medicine.

The HHMI grants confirm Arabidopsis «is still the Rolls Royce of model systems in plant biology,» says Dangl.

So the more that we can understand the human validation of our targets and perhaps even build model systems that take advantage of human biology,» the better off we'll be, he says.

«As far as we know, this is the first time anyone has used an insect system as a model for NIHL (noise - induced hearing loss),» says Daniel Eberl, UI biology professor and corresponding author on the study.

Working on Arabidopsis, a model plant used widely in plant biology labs, Cutler and his colleagues focused their efforts on tinkering with one of the plant endogenous systems involved in drought responses.

The approach combined experimental synthetic biology led by Mark Isalan, now Reader in Gene Network Engineering at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular Systems Biology lab at the CRG.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

The current group of centers, residing at universities and medical research facilities across the country, addresses fields such as systems biology, image processing, and biophysical modeling, all of which are related to computational neuroscience.

The research group, led by Erika Matunis, Ph.D., a professor of cell biology at the Johns Hopkins University School of Medicine, has been using the fruit fly as a model living system in which to study stem cells in their natural state.

To achieve such integration, Tara Oceans is driven by researchers with expertise in biological and physical oceanography, ecology, microbiology, systematics, molecular, cellular and systems biology, bioinformatics, data management, and modeling.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

Model systems, such as the mammalian gut bacterium E. coli for microbiology and the fruit fly for biomedicine, have been invaluable for deciphering complex biology.

Research Interests: Inflammatory bowel disease (IBD); Crohn's disease; ulcerative colitis; animal models of IBD; mucosal T - cell death and survival; tolerance to gut microbiota; interactions between immune and non-immune cells; immune - driven angiogenesis and lymphangiogenesis; intestinal fibrosis; intestinal myofibroblasts, extracellular matrix; systems biology; complex diseases

Systems biology research will aim to identify and validate mathematical models that can accurately predict interactions between immune system components in relation to vaccination, as well as develop state - of - the - art methods for the structural and functional analysis of vaccine candidates.

The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.

The Bergthaler laboratory pursues an integrative approach comprising infection models and tools of immunology, pathology and systems biology in order to dissect novel disease - relevant interactions between pathogens and the host.

Currently, researchers have access to powerful tools in biology to help them understand the ocean, such as microscopy and DNA sequencing, but are lacking essential tools in genetics to make robust experimental model systems.

Using the cichlid fish species as a model system gives us valuable insight into human biology and disease.

In addition, the systems biology research will heavily support the activities to improve the predictability of animal models.

We study the cell biology, binding proteins, structure and regulation of these important enzymes, using neuroendocrine cell lines as model systems.

«It validates the approach of using even very distant model systems, such as the fly, to study human biology.

The authors note that the formation of each different organ bud type may require some fine tuning to optimize tissue self - organization, and further addition of neural cell types may be necessary, but this research may soon provide exciting model systems for the study of basic biology and pathology as well as providing appropriate replacement tissues for the treatment of many patients with no other viable options.

For understanding the biology of gene - gene, gene - drug and gene - microenvironment interactions, a considerably broader range of in vitro and in vivo model systems is required — we are generating 1,000 organoid cultures from human cancers, characterising their genomes, functional dependencies and drug response, and we are expanding our in vivo models to study the interface between cancer and the immune system and microenvironment.

Objective: To provide data - driven and computational infrastructures and data - sharing platforms to support large - scale, system - level data integration and modeling, and enable predictive biology for pathogens and host - pathogen interactions for discovery research, clinical investigation, and therapeutic development for infectious diseases.

His research utilizes molecular biology, cell culture, and animal models to study your body's cannabinoid system in an attempt to further our understanding of Cannabis as a medicine, and possibly lead to the development of new drug compounds.»

Science - fisheries, natural resource management, fish behavior, fish biology, conservation; education - science, grades 6 - 12, biology, citizen science, public participation in research, model and systems thinking, evidence - based reasoning; social science - communication, anthropology, human dimensions, risk perception / communication.

Approaches successful in other systems, such as modeling signal transduction and synthetic biology methodologies [32] could improve future generations of detector plants by enhancing signal transmission and providing means to deal with biological «noise».

Sciara surfaced again in 1970 — 71 when Sydney Brenner spent two years in the library trying to figure out a good model system for developmental biology.

Thanks to genome sequencing and other methods there's been an explosion of emerging model systems where one can now reap the benefits of studying unique aspects of biology.

Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these models.

Systems biology aims to fit equations to living matter, creating mathematical models that promise new insight into disease and cures.

We will consider studies from any model system that provides insights into stem cell biology, and we encourage submissions on human stem cells.

Chlamydomonas is used as a model system for research on many very fundamental questions in cell and molecular biology: how do cells move?

An international group of scientists from 6 countries bring together their expertise to develop a combined experimental and systems biology platform for predictive modelling of cancer signalling.

In Entamoeba invadens, stage conversion can be induced, but its utility as a model system to study developmental biology has been limited by a lack of genomic resources.

memory process; hippocampo - cortical interactions; cholinergic system; glutamatergic system; Cellular and molecular biology; hippocampal neurogenesis; animal models of Alzheimer's disease; animal models of schizophrenia

Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue - specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem - cell - based disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging of stem cells, therapeutic applications, regenerative medicine, clinical and translational insights, stem cell research policies, ethical issues, and technical or resource - based innovations.

The researchers first discovered ascarosides as a signaling molecule in C. elegans, a nematode used as a model organism to study cell, developmental and nervous system biology, as well as human aging and diabetes.