Sentences with phrase «tamoxifen in»

Trace Determination of Tamoxifen in Biological Fluids Using Hollow Fiber Liquid - Phase Microextraction Followed by High - Performance Liquid Chromatography - Ultraviolet Detection

Research shows that a supplement called calcium D - glucarate (CDG) could be just as effective as Tamoxifen in treating estrogen dominance.

One study showed that when curcumin is used together with tamoxifen in treating melanoma (the deadliest form of skin cancer), the combined therapy selectively killed cancerous cells while preserving noncancerous cells.

This led the research team to advise that doctors combine progesterone with estrogen inhibitors such as Tamoxifen in their patients» treatment plans.

Joachim Liehr, a chemist at the University of Texas who has studied tamoxifen in rats, disagrees.

Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.

Not exact matches

Breast Cancer Care comment on claims that long - term use of Tamoxifen may increase proportion of oestrogen receptor (ER) negative cancers which develop in the opposite breast

«The study shows that long - term use of Tamoxifen does not increase incidence of breast cancer in the opposite breast, but it may increase the proportion of oestrogen receptor negative cancers.

Patients should be reassured that Tamoxifen remains very effective in reducing the overall risk of recurrences and deaths from breast cancer, as the authors state.

After determining the proper dosage of tamoxifen — an early trial resulted in a number of mouse deaths due to overactivation of Mecp2 — researchers settled on a four - week regimen of ramping up the gene's function.

Researchers led by Xiao - Jiang Li, MD, PhD and Shihua Li, MD, at Emory University School of Medicine, used genetically engineered mice in which the huntingtin gene can be deleted, triggered only when the mice are given the drug tamoxifen.

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.

In rare cases, tamoxifen has been tied to vision loss in women taking the druIn rare cases, tamoxifen has been tied to vision loss in women taking the druin women taking the drug.

Many experiments later, Wang, Wong and colleagues have shown that tamoxifen, a drug used to treat breast cancer, can help preserve photoreceptors — and sight — in mice with eye injuries.

Tamoxifen offered the same protection in mice with a form of retinitis pigmentosa.

«The killing power of microglia can be reduced by tamoxifen and this resulted in protection,» Wong says.

Tamoxifen provides structural and functional rescue in murine models of photoreceptor degeneration.

Other scientists have shown that tamoxifen and similar drugs might also reduce nerve cell damage in the spinal cord and brain.

In the most convincing study to date, a team of researchers in Cambridge has shown that a diet high in soya protein can alter women's hormones in a way that mimics the effects of the anticancer drug tamoxifeIn the most convincing study to date, a team of researchers in Cambridge has shown that a diet high in soya protein can alter women's hormones in a way that mimics the effects of the anticancer drug tamoxifein Cambridge has shown that a diet high in soya protein can alter women's hormones in a way that mimics the effects of the anticancer drug tamoxifein soya protein can alter women's hormones in a way that mimics the effects of the anticancer drug tamoxifein a way that mimics the effects of the anticancer drug tamoxifen.

The Cambridge research also showed that there were similarities in the biological effects of soya protein containing isoflavones and the potent synthetic anti-oestrogen, tamoxifen.

In animal and cell culture studies, the drug inhibited growth both in estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast canceIn animal and cell culture studies, the drug inhibited growth both in estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cancein estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cancein cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cancer.

Of these variants, reported today in the journals Nature and Nature Genetics, 65 are common variants that predispose to breast cancer and a further seven predispose specifically to oestrogen - receptor negative breast cancer - the subset of cases that do not respond to hormonal therapies, such as the drug tamoxifen.

Image shows the complex shape of individual oligodendrocytes (OLs) and myelin in adult mice injected with tamoxifen.

Indeed, another experiment in live mice showed that the estrogen - blocking drug tamoxifen slashed platelet counts by 45 % within 9 days.

«By paralleling tamoxifen», says McCague, «hopefully minimal side effects will result, which is an important consideration in the long - term therapy of elderly patients.»

Gerry Potter and Ray McCague of the Institute of Cancer Research in Surrey based their design strategy on tamoxifen, a drug widely used for treating breast cancer.

Tamoxifen, a drug currently used to treat breast cancer, also kills a fungus that causes a deadly brain infection in immunocompromised patients.

«Although the study was small, the difference in TGF beta - 1 levels between those who had and those who had not had tamoxifen was enormous and statistically significant,» says Colletta.

«This work sets the stage for additional animal studies to see if tamoxifen can be used as a drug in people and will allow us to design new drugs related to tamoxifen that are better antifungals,» says Damian Krysan of the University of Rochester, an author on the study.

Healthy women in the US and Canada are soon to begin a trial of the drug tamoxifen to see whether it prevents breast cancer.

Last year, the plans ran into a last - minute hitch when the Medical Research Council withdrew its support after research showed that tamoxifen can alter genetic material in rats» liver cells (This Week, 14 March 1992).

A team working at the Institute of Cancer Research and the Royal Marsden Hospital in London, in collaboration with scientists at the National Cancer Institute in Bethesda, Maryland, has found that tamoxifen also works by encouraging the cells surrounding a tumour to produce a «growth factor».

In rats, tamoxifen causes liver tumours and appears to alter DNA in liver cells (This Week, 29 February and 14 MarchIn rats, tamoxifen causes liver tumours and appears to alter DNA in liver cells (This Week, 29 February and 14 Marchin liver cells (This Week, 29 February and 14 March).

Tamoxifen is effective in treating breast cancer and in reducing the risk of a woman developing a second tumour in her opposite breast.

But recent work shows that while these cancers lack estrogen receptors, progesterone receptors, and aren't driven by the gene HER2, up to a third of these tumors express the androgen receptor — clinical trials are underway to inhibit the androgen receptor in these tumors in much the same way that the drug Tamoxifen inhibits estrogen receptor in estrogen - receptor - positive breast cancers.

The study looked at 2,980 postmenopausal women with DCIS in 14 countries, who were either given anastrozole or tamoxifen for five years after surgery.

We already know that tamoxifen can reduce the risk of cancer developing in some women who have early changes in the breast, but some get unacceptable side effects.

There are also preventive therapies — such as tamoxifen or the trial drug anastrazole — that interfere with the production of the hormone oestrogen, implicated in many breast cancers.

Letrozole is approved by the FDA for the adjuvant treatment of early - stage breast cancer in postmenopausal women who have already been treated with 5 years of tamoxifen therapy.

And the reporter is also relatively insensitive, meaning a large dose of tamoxifen is needed to induce labeling in a single clone, he adds.

As a next step, the researchers plan to further study the relationship between hot flashes and breast cancer progression by measuring the tamoxifen metabolites in breast cancer survivors.

The study *, published in the British Journal of Cancer ** today (Wednesday), showed a potential link between the activity of a gene called BCAR4 and the likelihood that a breast cancer tumour will not respond to tamoxifen — widely used to treat women with breast cancer.

Tamoxifen has been used for decades to treat breast cancer and has recently been shown to prevent breast cancers in many women.

In addition to a range of antibodies, Abcam offers over 4,000 pharmacological tools covering receptor agonists and antagonists, like Tamoxifen Citrate and oestrogen receptor, which is also used in the control of gene expressioIn addition to a range of antibodies, Abcam offers over 4,000 pharmacological tools covering receptor agonists and antagonists, like Tamoxifen Citrate and oestrogen receptor, which is also used in the control of gene expressioin the control of gene expression.

By day 60, the average tumor volume in mice treated with tamoxifen plus CDB4124 was 70 percent lower than the original tumors.

They gave some of the rats flutamide, which blocks testosterone from activating receptors in the brain, and gave others tamoxifen, which blocks estrogen receptors, finding that the drugs lessen the anxious behavior in the rats.

These Cre / FLP versions are retained in the cytoplasm until estrogen receptor ligand Tamoxifen is added.

For example the researchers used the CRE - ERT2 mouse model validated at the ICS, in which Cre function is controlled by the promoter of Atypical Notch ligand Delta - like homologue1 (Dlk1) under Tamoxifen activation, a skin fibroblast marker, to carry out temporal and tissue specific inactivation of key genes involved in skin fibroblast diversity.

It was used in this study for the first time to study factors that cause estrogen receptor positive breast cancer to recur during tamoxifen therapy.

Researchers further demonstrated that changes in these genes were reversed by adding well - tolerated epigenetic modifying drugs, valproic acid and hydralazine, to tamoxifen therapy regimen.