Sentences with phrase «tamoxifen resistance»

«We have found that the same genes responsible for tamoxifen resistance in our animals are also turned off in human breast cancer cells that do not respond to the drug,» she says «Because these genes were epigenetically silenced — meaning they were not irreversibly altered, just switched off — it was possible to turn them back on.

These drugs also prevented tamoxifen resistance and recurrence of breast cancer in the animal model.

Not exact matches

In animal and cell culture studies, the drug inhibited growth both in estrogen - dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and / or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen - dependent breast cancer.

Many investigators had assumed that once breast cancer cells developed resistance to tamoxifen, they would be resistant to all drugs that target the estrogen receptor, McDonnell explained.

«We discovered that the estrogen receptor is still a good target, even after it resistance to tamoxifen has developed,» he said.

Tamoxifen prevents oestrogen from stimulating growth of breast cancer cells but some tumours can eventually develop resistance to the treatment, making the drug ineffective.

University of Miami School of Medicine Resistance to tamoxifen: a consequence of altered p27Kip1 regulation during breast cancer progression

WASHINGTON (September 8, 2016)-- An animal study suggests that resistance to tamoxifen therapy in some estrogen receptor positive breast cancers may originate from in utero exposure to endocrine disrupting chemicals.