Sentences with phrase «target aggressive cancers»

«It never ceases to amaze me how a simple molecule, such as saccharin — something many people put in their coffee everyday — may have untapped uses, including as a possible lead compound to target aggressive cancers,» says Robert McKenna, Ph.D., who is at the University of Florida.

New insights from neutron analysis of glaucoma drugs and their enzyme target may help scientists design drugs that more effectively target aggressive cancers.

«This remodeling process of the cell proteome by autophagy is an important immune - suppressive survival mechanism for Ras - driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.

Not exact matches

Sonali Setua, a PhD student who worked on the project, said: «It was hugely satisfying to chase such a challenging goal and to be able to target and destroy these aggressive cancer cells.

«This study demonstrates that targeted fusion - guided biopsy could significantly enhance our ability to identify patients with high - risk prostate cancers that need more aggressive treatment,» says lead author Mohummad Minhaj Siddiqui, MD, assistant professor of surgery at the University of Maryland School of Medicine and director of urologic robotic surgery at the University of Maryland Marlene and Stewart Greenebaum Cancer Center.

«This study forms the basis for future research in patients with breast cancer and offers hope for targeted therapy for patients with aggressive triple - negative inflammatory breast cancer,» said lead researcher Mateusz Opyrchal, M.D., Ph.D., Assistant Professor of Oncology at RPCI.

Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.

«Study identifies potential treatment target for pancreatic cancer: Molecular signature found in 30 percent of PDAC tumors associated with more aggressive cancer.»

This new generation of viruses has been genetically «targeted and armed,» says Winald Gerritsen of the VU University Medical Center in Amsterdam, who is involved in an early human trial of an engineered adeno - associated virus that attacks glioblastoma, an aggressive form of brain cancer.

UCLA researchers found that conventional «blind» biopsy failed to reveal the true extent of presumed low - risk prostate cancers, and that when targeted biopsy was used, more than a third of these men had more aggressive cancers than they thought.

The Cancer Vaccine Collaborative is working on treatments that target multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tCancer Vaccine Collaborative is working on treatments that target multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tcancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tumors.

In the study, the genetic targets were messenger RNA (mRNA) that code for certain proteins known to be biomarkers for aggressive breast cancer cells.

Genetically modified Salmonella bacteria target tumors and make the immune system extra aggressive toward cancer cells.

Based on an analysis of existing evidence, published in an opinion article in the Nature Reviews Clinical Oncology journal on January 20, Dr. Narod argues that to achieve a cure, rather than simply delay progression or reoccurrence of the disease, women should be first treated with aggressive surgery to remove all clinically - detectable cancer cells, followed by targeted chemotherapy to the abdomen (intraperitoneal chemotherapy).

A team of researchers led by UC San Francisco scientists has identified a new drug target for triple - negative breast cancer, an aggressive disease subtype that has the poorest outcomes and accounts for as many as one in five cases.

The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, says Professor Ivaska.

This provides a potential target for treating triple negative breast cancer, the most aggressive form of the disease.

«Potential pancreatic cancer target challenged: New research finds PDX1 critical for cancer growth, but blocking it may lead to more aggressive tumors.»

A unique approach to targeting the abnormal T - cells that cause T - cell lymphomas could offer hope to patients with the aggressive and difficult - to - treat family of cancers, finds a study involving researchers from Cardiff University.

In the era of personalized cancer therapy, patients with TNBC remain at considerably higher risk of relapse and death than patients with other breast cancer subtypes, due to the aggressive nature of TNBC and the lack of newer targeted therapies for the disease.

«Targeting cancer without destroying healthy T - cells: Unique approach to treatment of rare and aggressive blood cancers.»

A research team led by Christine Brown, Ph.D., and a clinical team headed by Behnam Badie, M.D., has received a $ 12.8 million grant from the CIRM to fund a phase 1 chimeric antigen receptor (CAR) T cell trial targeting an aggressive brain cancer called malignant glioma, which includes glioblastoma.

My honours project was centred upon exploring mechanisms that allow for the progression of Inflammatory Breast Cancer, a highly rare and aggressive form of advanced breast cancer, and whether we could target these previously unknown mechanisms with novel therapeCancer, a highly rare and aggressive form of advanced breast cancer, and whether we could target these previously unknown mechanisms with novel therapecancer, and whether we could target these previously unknown mechanisms with novel therapeutics.

If validated in larger studies, this breakthrough could mean that it may be possible to identify those at the highest risk of their breast cancer spreading, with more aggressive treatments targeted specifically to them, while those at low risk could be spared treatments that may not benefit them, as well as the subsequent side - effects.

Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer JCEM March 28, 2017 Keisuke Enomoto, Xuguang Zhu, Sunmi Park, Li Zhao, Yuelin J. Zhu, Mark C. Willingham, Jun Qi, John A. Copland, Paul Meltzer, and Sheue - yann Cheng Anaplastic thyroid cancer (ATC) is one of the most aggressive cancers in hCancer JCEM March 28, 2017 Keisuke Enomoto, Xuguang Zhu, Sunmi Park, Li Zhao, Yuelin J. Zhu, Mark C. Willingham, Jun Qi, John A. Copland, Paul Meltzer, and Sheue - yann Cheng Anaplastic thyroid cancer (ATC) is one of the most aggressive cancers in hcancer (ATC) is one of the most aggressive cancers in humans.

The CRISPR - Cas9 genome editing system could help fight cancer, and now, researchers have used the tool to target what they call cancer's command center, in a treatment that's been shown in mice to shrink aggressive tumors and increase survival rates, without harming healthy cells.

Research led by Dr. Carlos Arteaga, Director of the Harold C. Simmons Comprehensive Cancer Center, has identified potential targets for treatment of triple negative breast cancer, the most aggressive form of breast cCancer Center, has identified potential targets for treatment of triple negative breast cancer, the most aggressive form of breast ccancer, the most aggressive form of breast cancercancer.

This gene finding may allow scientists to identify patients with this aggressive form of the cancer and target them with additional therapies.

«This suggests,» they add, «that metformin may preferentially target aggressive [prostate cancer],» and there are currently trials trying to find this out.

December 13, 2011 Molecular markers can predict spread of cancer, guide treatment Molecular markers found in cancer cells that have spread from a primary tumor to a limited number of distant sites can help physicians predict which patients with metastatic cancer will benefit from aggressive, targeted radiation therapy.

Leigh Ellis, PhD, and colleagues at Roswell Park Comprehensive Cancer Center (Roswell Park) have identified two genes that appear to be simultaneously overexpressed in aggressive prostate cancers resistant to the androgen - targeted treatments enzalutamide and abiraterone acetate.

Together, these data indicate that MELK is a normally non-essential kinase, but is critical for BBC and thus represents a promising selective therapeutic target for the most aggressive subtype of breast cancer.

Tumor - targeting nanoparticles loaded with a drug that makes cancer cells more vulnerable to chemotherapy's toxicity could be used to treat an aggressive and often deadly form of endometrial cancer, according to new research...