Sentences with phrase «target cell bodies»

Not exact matches

The start - up's premiere product, the Thin Ice vest, uses cold therapy to target areas of the body with high concentrations of thermoreceptors, which are nerve cells that are able to detect the presence of hot or cold temperatures.

Instead of being injected into the bloodstream and exposed to the rest of the body's tissue — with all the unpleasant side effects, as is the case with chemotherapy — these agents only target cancer cells.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

Her doctor suggested Erbitux — a proven cancer drug that targets cancer cells exclusively, unlike conventional chemotherapies that more crudely kill all fast - growing cells in the body — and Aucoin went to a clinic to begin treatment.

However, these same inflammatory responses can become part of a disease if they mistakenly target the body's own cells, such as occurs in the case of autoimmune conditions like Crohn's disease.

Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.

Based on the evolutionary idea that targeted epigenetic stochasticity can improve adaptation, these observations could explain how cancer cells are good at evading chemotherapy treatments and spreading from one part of the body to another, he adds.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

One class of immunotherapeutic drugs is known as «checkpoint» inhibitors, as they target checkpoints in immune system regulation to allow the body's natural defenses, such as white blood cells, to more effectively target the cancer.

Which areas in the body are targeted by T cells and the impact they will have depends on various factors.

«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.

The researchers found that HIV spiked into semen was more successful than the virus alone at infecting T cells and macrophages (immune system cells that are believed to be the infection's initial targets in the body).

Another strategy, which Steinman and others were studying, involves a therapy to target dendritic cells inside the body rather than taking them out and personalizing therapy for each patient.

Conventional therapies target rapidly dividing tumor cells, but are unable to eradicate the highly chemoresistant tumor initiating cells (TICs), ultimately responsible for relapse and spreading of the tumors in other parts of the body.

Using the JEDI technology, Mount Sinai researchers uncovered evidence that immune cells can find cells in the brain expressing their target antigen, even in non-infected states, which provides evidence of an immune surveillance pathway within the body's central nervous system.

This is characterised by the targeted strengthening of the body's own immune cells, unlike in chemotherapy, in which the aim is direct destruction of the cancer cells.

This similarity suggests that the proteins could promote cell growth and development in target tissue within the female's body and as a result influence female reproductive behaviour.

Once engineered cells are engrafted into laboratory mice, their GRN becomes even closer to that of the true target tissue, indicating that the body's own tissues contribute signals to enhance the performance of transplanted cells.

Thus, the soluble form of a-Klotho can go to any cell in the body and act as a co-receptor for FGF23, rendering every cell a possible target of FGF23, representing a major paradigm shift.

«Now that we've identified where the replication - competent virus is hiding, we can start work towards targeting these cells with new therapies aimed at fully eliminating HIV from the body,» Associate Professor Palmer concluded.

Other vaccines in trials target the blood - cell stage, and contain a parasite protein called AMA - 1, meant to prime the body's immune system to attack it.

The body then produces such a strong response that it also starts to target healthy cells.»

Researchers have been seeking a way to improve the body's ability to combat the virus by engineering blood - forming stem cells to specifically target and kill HIV - infected cells for the life of the individual.

Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

The two cell types are important to a broad range of organ systems in the body and play active roles in diseases that could be targets for nucleic acid therapies.

The trouble is that the virus targets not only the lymphocyte cells, which include T cells — a key component of the body's immune system helping to fight diseases — but also other immune system cells.

Conventional treatments for diseases such as cancer can carry harmful side effects — and the primary reason is that such treatments are not targeted specifically to the cells of the body where they're needed.

Tweaking the DNA bots could also ensure they only target specific cells in the body, minimising harmful interactions elsewhere in the body.

«We thought we could adapt this technology that's really good at killing all B cells in the body to target specifically the B cells that make antibodies that cause autoimmune disease,» said Milone.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

University of California, Berkeley researchers have now found a promising new drug target within that pathway that is appealing, in part, because it appears to control production of only a few percent of the body's many proteins, those critical to regulating the growth and proliferation of cells.

The auto - reactive B cells produced autoantibodies that mistakenly targeted proteins within their own body, in particular targeting immune inflammatory molecules called interferons and interleukins.

Scientists were able to selectively target the cells that cause autoimmune disease by dampening down their aggression against the body's own tissues while converting them into cells capable of protecting against disease.

Gene therapy, which often employs viruses to deliver the good genes to a body's target cells, has been known to trigger severe immune responses and was blamed for the death of an 18 - year - old in 1999, who was receiving gene therapy for a hereditary metabolic disorder.

While radiotherapy can precisely target just the tumor site, systemic chemotherapy spreads a wide net, sending drugs speeding throughout the entire body in an attempt to kill cancer cells while also killing many healthy cells.

Due to an increasing body of evidence which suggests that the host immune response may be critical to the efficacy of oncolytic virotherapy, Shah and his colleagues also developed an immunocompetent melanoma mouse model and explored treating with both stem cell loaded oHSV and immune checkpoint blockers such as the ones that target the PD - 1 / PD - L1 pathway.

These cells are then injected into the area of the body being targeted for tissue regeneration.

However, it is a difficult target for drug intervention because it is a vital component of most cells in the body; curbing its activity could kill all cells, including healthy ones.

It is in this final tank that the engineered cells are stimulated to secrete the protein product — the monoclonal antibody itself, a protein derived from the mammalian immune system that can bind to a very specific target in the body, such as a tumor cell.

Potential treatments being studied include training the body to better tolerate myelin, drugs that target the immune system's B cells, blocking proteins that cause inflammation in the body, or even «rebooting» the entire immune system.

Unlike the case of most gene therapies that are intended to permanently alter their target cells, however, Oisín's senoablative genetic constructs will not be inserted permanently into the patient's genome: instead, its genetic payload will be expressed temporarily from the main body of the cell, following which the construct will be passively degraded by normal cellular metabolism.

Immune cells are able to target threats selectively within the body — be they virally infected cells, bacteria, parasites, or cancerous cells — while, in most normal cases, leaving healthy cells unharmed.

Radiation therapy uses high - energy radiation to target cancer cells in a specific part of the body.

Tissues targeted (as reported in animals): Primarily blood, immune, and stem cells removed from the body; localized electroporation to skin

Our targeted delivery adds to the specificity of our mechanism of action, with therapeutic siRNA molecules only reaching the intended target cells in the body

Our delivery systems ensure further specificity by delivering therapeutic siRNA only to one target cells in the body.

FlyMAD, or Fly Mind Altering Device, with its inbuilt video tracking system allows the researchers to target light or to heat specific body regions within the fly's body even while the insect is in motion and to simultaneously analyse brain cell activity.

Compared with other viral vehicles, the immune system tends to ignore AAV, and the carrier is able to target specific cell types in the body.

Targeting Pol III in the fat body did not have the same effect, and targeting Pol III in neuronal cells extended life only Targeting Pol III in the fat body did not have the same effect, and targeting Pol III in neuronal cells extended life only targeting Pol III in neuronal cells extended life only a little.