Sentences with phrase «target cell population»

Second, when hu - PBMCs were treated with the IL - 15 superagonist in vitro and subsequently incubated with K562 cells, a well - characterized NK target cell population, the treated NK cells showed increased Cd69 and CD107a expression, markers for activation and degranulation, respectively, compared to untreated hu - PBMCs.

New CFSE - based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population.

When using the ClonTracer system, lentiviruses containing these barcodes infect the target cell population at low multiplicity of infection (MOI) such that each individual cell receives only one barcode.

«Knowing about these Lgr5 cells is valuable for us because it gives us a target cell population to study as we try to figure out how to better manipulate them and turn them into hair cells in an adult,» Edge says.

«A biological approach to precision medicine targets endless number of diseases: Self - assembling platform effectively delivers inhibitory RNA molecules to targeted cell populations.»

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

The team used a combination of experiments to zero in on the molecular activity of melittin at the «minimal inhibitory concentration» (MIC), the lowest concentration that's been shown to slow the growth of target cell populations.

Unlike other studies on p53, however, which target cell populations that average many cells together, Dr. Lahav developed a new approach, quantifying p53 at high temporal resolution in single cells and taking into account that «individual cell decisions are crucial in the development and treatment of cancer.»

Not exact matches

And it CAN be a good for political organizing, if your targets are in populations with high cell - phone and / or Twitter usage (for instance, younger — and plugged - in — urban black and latino voters).

Participants with high - risk bacterial communities, which are commonly found in the population of women studied, also had increased numbers of genital CD4 + T cells — white blood cells that are HIV's primary target.

At one level, optogenetics is nothing more than using light to control a targeted population of cells.

For that, they quantified how 85 nanoparticles delivered DNA barcodes to eight cell populations in the spleen, and found that cell types derived from myeloid progenitors tended to be targeted by similar nanoparticles.

«If the CD117 cell population does lead to tumor initiation or cancer reoccurrence, this cell marker could become a therapeutic target,» she says.

Another hypothesis is that progesterone boosts the population of Langerhans cells in the vaginal mucosa, thought to be one of the main targets of HIV in the female genital tract.

When coexpressed with a recombinase, these intracellularly expressed ssDNAs target specific genomic DNA addresses, resulting in precise mutations that accumulate in cell populations as a function of the magnitude and duration of the inputs.

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

Targeting the labeled cells for analysis, they revealed that their organoids contained a population of sensory cells that have the same functional signature as cells that detect gravity and motion in the human inner ear.

To develop new, targeted treatments to eliminate these residual infected cells, we need to find exactly where in the CD4 T lymphocyte population the virus hides.

Thus, our selection strategies, which were based on targeting endothelial populations that expressed both of these inducible glycoproteins, suggest that the endothelial cell lines generated in this study are most likely from this microcirculatory region.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies.

Now it seems likely we will find other Senolytics that favor other cell populations and one could in theory create a combination or regime that could be used to target more cells.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies,» said Tonegawa in a statement.

They are the only means to target and manipulate specific cell types (populations) within neuronal networks in living animals.

In a Nature paper introducing the optogenetic tool, Konermann and Zhang showed they could package LITEs in viral vectors and genetically target them to specific cell populations.

With the discovery of VHL alterations in the majority of clear cell RCCs, targeted therapies were studied in this population.

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

The players are the healthy cells, the targeted cancer cells and the resistant cancer cells and the game is played over and over again in the computer simulation as the different populations of cells compete.

Sorting breast cancer cells using a new reporter construct allows the interrogation of a highly pure population of cancer stem cells and may allow for the discovery of new therapeutic targets

C4 - 2B cell population averaged PNB lifetimes (ns) under various NP targeting and laser excitation conditions (wavelength, nm / fluence, mJ / cm2).

In 2016, Dmitry I. Gabrilovich, M.D., Ph.D., program leader of Wistar's Translational Tumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

We show enzymatic targeting of an NMDA - R antagonist, MK801, to a molecularly defined neuronal population with the cell - type - selectivity of genetic methods and the temporal control of pharmacology.