This understanding of cancer's evolution has key implications for treatment, he noted, «In addition to pointing out that we will need to
target driver genes that are mutated early in cancer, this evolutionary approach provides a method that accurately characterizes which genes are being mutated early and late.
Not exact matches
«The major known cancer
driver genes are often mutated in the primary tumor and all metastases, and successfully
targeting them in therapy could provide widespread therapeutic benefit,» said Townsend.
She is particularly interested in the identification of cancer
driver mutations,
genes and pathways across tumor types and in the study of their
targeted opportunities.
We have hundreds of these
gene pairs in hand and are now developing drugs
targeting the synthetic lethal partner of major oncogenic
drivers.
The new
Driver - Map ™ Human Genome - Wide
Gene Expression Profiling kit, is a
targeted RNA expression profiling assay.
The Cancer
Gene Census (CGC) database contains 547 such gene across various cancer types.5 Remarkably, few driver genes having specific point mutations appear to be sufficient to rewire signalling networks in cancer, 1 which at the same time shows that — at least from the mutational side — cancer does not consist of an «infinite» number of different diseases, and in many cases treatment options targeted against driver genes might be transferred from one case to the n
Gene Census (CGC) database contains 547 such
gene across various cancer types.5 Remarkably, few driver genes having specific point mutations appear to be sufficient to rewire signalling networks in cancer, 1 which at the same time shows that — at least from the mutational side — cancer does not consist of an «infinite» number of different diseases, and in many cases treatment options targeted against driver genes might be transferred from one case to the n
gene across various cancer types.5 Remarkably, few
driver genes having specific point mutations appear to be sufficient to rewire signalling networks in cancer, 1 which at the same time shows that — at least from the mutational side — cancer does not consist of an «infinite» number of different diseases, and in many cases treatment options
targeted against
driver genes might be transferred from one case to the next.