Sentences with phrase «target effects of a drug»

In some cases, the off - target effects of a drug could make it useful for treating conditions other than the one for which it was originally developed.

Not exact matches

Merck is the latest company to weather bad news in the Alzheimer's drug race, halting a late - stage trial yesterday in an experimental amyloid - targeting candidate called verubecestat after a data monitoring committee said there was «virtually no chance of finding a positive clinical effect,» Reuters reported.

Understanding the biological and genetic basis to drug resistance and cancer progression has enabled researchers to identify and develop a targeted drug that may prove to be beneficial in this type of cancer, without causing unmanageable side - effects.

Hannes Stockinger, the senior author of the study, adds: «If we coupled this delivery method with screening of patient's tumours for the presence of a unique surface protein, which we can target with the Fab fragment - functionalized liposomes, we might be able to treat tumours more efficiently and decrease the side effects of the delivered anti-cancer drugs substantially.

One of the greatest challenges in modern medicine is developing drugs that are highly effective against a target, but with minimal toxicity and side - effects to the patient.

Other trials of this drug target in lung cancer have not worked, and the drugs» effects in colorectal cancer are also questionable, Stambolic says.

«Targeting FAS - ligand could be a good adjunct therapy to boost the effects of immunotherapeutic drugs.»

She dreams of what will someday be possible with targeted drugs that exploit the best aspects of the gastric bypass effect.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

Therefore we believe that anti-VEGF treatment is a logical target for new drug treatments that could help enhance the effect of better lens design and placement, to prevent secondary cataract.»

It also suggests the possibility of designing better sleeping pills by finding compounds that mimic adenosine's effects, says McCarley, who points out that current drugs do not target the adenosine receptors.

The scientists believe the drug targets a stress pathway specific to alcoholics because it has been shown to have little effect on stress levels in other types of patients.

By targeting different hormones that help the body manage its own insulin levels — and by reducing side effects such as weight gain — three drugs recently approved by the FDA avoid most of the major problems associated with past diabetes treatments.

Eventually the promise of other drug targets, along with the possible side effects of targeting NPY, put a damper on the effort — until now.

«Since epalrestat is already on the market and has no major adverse side effects, our study provides a proof of principle that it could become a valuable targeted drug for the clinical treatment of basal - like breast cancer,» Dong says.

Calcium is a «promiscuous» signal used by all cells for a wide variety of processes, he notes, and thus drugs that target it could have major side effects.

For example, light - activated switches can fine - tune anti-cancer drugs, so they target only cancer cells and not healthy ones, thereby eliminating the side effects of chemotherapy.

Previously, only two targets of artemisinin have been identified, and their correlation with the powerful parasite - killing effect of the drug has been questioned.

Our next step is to investigate the effects of targeting the Erk - Ras - ETS pathway in more complex animals, such as mice, with a view to developing a drug regime that could be suitable for testing in humans.

Because some of these neighbour proteins are as central and as global as the cancer - related proteins themselves, and link to so many other processes in the cell, there's a strong likelihood that drugs targeting them may have strong side - effects.

These were thought to be ketamine's target, but clinical trials of other drugs that target them have largely yielded disappointing effects on depression, says Gould.

Researchers in Sweden have just identified a number of drug targets that can be used in the development of new efficient treatment strategies with minimum side effects.

Being able to detect and measure the amount of mutant huntingtin present in the nervous system will be a valuable way of seeing whether the gene - silencing drug is hitting its target and has the intended effect, lowering the amount of disease causing mHTT protein.

This could be a good way to test new types of drugs that target cancer cells specifically and spare patients the side effects from treatments if they are not working.»

Poirier hopes that with further funding and support, his studies will lead to the development of drugs targeted to specific genotypes, making them safer and more effective and reducing side effects.

Researchers at the Perelman School of Medicine, University of Pennsylvania, show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be through inhibiting HDAC activity, and thus warranting the reassessment of the molecular targets of this class of drugs.

Learning why current anesthetics are so potent and sometimes dangerous will lead to a new generation of safer targeted drugs without unwanted side effects

The fact that venoms are mixtures of specifically targeted toxins rather than single toxins is exactly what makes them such rich sources of potential drugs — that's all a drug is, really, a compound that has a desired effect on our bodies.

«Instead of targeting mGluR5, which is a very widespread molecule with many different functions, now we can target the persistent sodium current directly, using already approved drugs that are more specific and less likely to cause side effects,» Klyachko said.

In principle, if further tests bear out the protective effects of the two antibodies, then optimized versions of them, or small - molecule drugs that hit the same target, could be developed as treatments for rhinovirus infections.

«No drugs are free of off - target effects,» he notes.

The team found that, while some drugs they tested this way were highly selective in the sense that they bound only to their intended protein targets, others showed evidence of strong bindings to additional, «off - target» proteins — which could produce their own biological effects.

We hope that by understanding the processes involved in inflammation we will herald the arrival of new and targeted anti-inflammatory drugs that have fewer side effects than what is currently available.»

«Identifying a cancer driver is crucial for cancer treatment because it allows the use of targeted therapies, which have less side - effects than conventional chemotherapy drugs, against a particular protein,» said Kurokawa.

And so the challenge is matching drugs with many effects to cancers with many causes in a way that best maps the drugs» effects onto the intended targets,» says Aik Choon Tan, PhD, investigator at the University of Colorado Cancer Center and associate professor of Bioinformatics at the CU School of Medicine.

What makes them different, he said, is that the whole point of a drug is to have a very targeted effect from the lowest dose possible.

Their new approach also reduces the potential for drug abuse and avoids the most common side effects — sedation and anxiety — of drugs designed to target the nervous system's kappa opioid receptors (KORs).

The Wyss team has unveiled not only a novel design of their «targeted EPO,» but also «targeted interferon alfa,» a cancer drug that can otherwise cause side effects including flu - like symptoms, mood fluctuations, and depression.

A new strategy for engineering protein fusions — to make specific cell - targeted drugs without side effects — could enable a safer, more potent class of protein drugs.

Most drugs exert their therapeutic effect by binding to a target protein molecule, thereby interfering with the normal function of the protein.

The process of drug discovery has been dominated in recent years by the screening of large libraries of structurally diverse small molecules for effects on target proteins associated with disease.

If drug makers incorporated this technique into their early drug discovery process, he said, it would help identify which version of an atropisomeric compound actually targets the kinase they want to target, cutting the potential for side effects and helping to usher drugs past strict regulatory hurdles and into the hands of waiting patients.

These promising results have already raised the interest of the pharmaceutical industry and led the researchers to patent DGKi as a drug target, as they are keen to explore the issue further, searching for molecules that strongly inhibit DGKi without causing side - effects.

Although doctors have long incorporated personal information like family history into treatment plans, personalized medicine holds the promise of revolutionizing medical care by using knowledge of molecular biology and genetics that will allow more precise diagnoses, better diagnostic tests, greater predictability of disease course, more successful therapies by targeting the right treatments to the right patients, and improved patient safety by selecting drugs and their proper dosage to reduce adverse side effects.

Researchers found that the drugs, called Hsp90 inhibitors, specifically target and inactivate a mechanism commonly used by prostate cancer cells to evade the effects of standard treatment.

Further, its side effects are intolerable for many patients, limiting its use and creating an urgent need for more targeted drugs with minimal risks,» said Evan Snyder, M.D., Ph.D., professor and director of the Center for Stem Cells and Regenerative Medicine at SBP, and senior author of the study.

We have known for a while that microRNAs are important in cancer, but their diversity of roles has meant it's been difficult to target them with drugs without causing toxic side - effects.

Currently we are using this system for identification of novel therapeutic targets and for screening and characterization of the effects of anti-diabetic drugs.

«In order to go beyond targeting an oncogene and just hoping for the best, we need to understand the actual biological effects of drugs inside cells.

«With targeted nanoparticles, you have far fewer side effects, so it is anticipated that a drug combination can be selected based on the biology and medicine rather than the limitations of the drugs.»