Sentences with phrase «target epitopes»

Removing the cytoplasmic domain may distract the immune response and instead generate antibodies that target epitopes on Env that would not lead to protection.

Some targeted epitopes in the second variable (V2) loop of HIV Envelope, while others targeted glycans.

Jin J, Liss NM, Chen DH, Liao M, Fox JM, Shimak RM, Fong RH, Chafets D, Bakkour S, Keating S, Fomin ME, Muench MO, Sherman MB, Doranz BJ, Diamond MS, Simmons G. Neutralizing monoclonal antibodies block Chikungunya virus entry and release by targeting an epitope critical to viral pathogenesis.

Not exact matches

DPX - RSV is a small, B - cell epitope peptide vaccine targeting the unmet medical needs in respiratory syncytial virus (RSV).

Each epitope is targeted by a pool of T cells bearing different, but specific, T cell receptors to recognize and respond.

The epitope where 2D22 binds to the virus may therefore represent a potential vaccine target.

The epitope defined by HMAb 2D22 is a potential target for vaccines and therapeutics.

Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems.

Neutralizing antibodies primarily recognized the envelope protein domain III (EDIII) or quaternary epitopes on the intact virus, and an EDIII - targeted antibody protected mice against lethal infection.

In contrast, the tier 1 NAbs targeted linear epitopes in the gp120 V3 region.

In some cases, these NAbs targeted components of the glycan shield previously associated with bNAb epitopes.

Tier 2 NAbs recognized conformational epitopes that differed between animals and in some cases overlapped with those recognized by broadly neutralizing antibodies (bNAbs), whereas tier 1 responses targeted linear V3 epitopes.

epitope - a specific part on the surface of a virus that is targeted for destruction by the body's immune system.

Epitope targeted might be preferentially expressed on HIV Env.

Epitope - tagged dopamine transporter knock - in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons.

< i > In vivo performance of polymer nanocarriers dually - targeted to epitopes of the same or different receptors.

Investigation of Strategies for Drug Delivery by Combination Targeting of Nanocarriers to Multiple Epitopes or Receptors.

The high specificity with one epitope target makes our monoclonal antibodies very efficient, reflecting in less background staining and low cross-reactivity with other proteins.

Emerging escape variants were generally resistant to the related V3 - specific antibody PGT121, but remained sensitive to antibodies targeting nonoverlapping epitopes, such as the anti-CD4-binding-site antibodies 3BNC117 and VRC01.

discovery of new vaccine targets by innovative approaches that allow the identification of non-classical vaccine antigens like non-protein antigens and subdominant epitopes and novel protein candidates

The overall score encompass several factors: reproducibility of the antibody staining in different cell lines (and if signal strength correlates with RNA expression levels); assays for enhanced antibody validation by using antibodies binding to different epitopes on the same target protein (independent antibodies), by knockdown / knockout of the target protein (genetic methods) and by matching of the signal with a GFP - tagged protein (recombinant expression); experimental evidence for location described in literature.

If we think that the antibodies are keys that correspond to a lock target located in the antigen, the epitope would slot corresponding to a specific key.

Our immuno - oncology product candidates are being developed in two separate approaches: one that targets specific antigens and / or epitopes (such as CMB305 and in our neoantigen collaboration); and an alternative approach that leverages the endogenous antigens found in the tumor microenvironment via intratumoral immunization (such as G100).

Epitopes are specific target structures recognized by the immune system of human or animal body.

We predicted that these diversified epitope regions would be the targets of mutation as the 2009 H1N1 pandemic (pH1N1) lineage evolves in response to the development of population - level protective immunity in humans.

This approach is considered «passive,» as nanoparticles do not use ligands targeting specific epitopes on the cell surfaces.