We use our proprietary technology platform to advance the next generation of genetic medicines, designed to intervene at the root of the problem by
targeting the expression of disease - causing genes.
Class - specific inhibition of Gq - mediated signaling was produced in the hearts of transgenic mice
by targeted expression of a carboxyl - terminal peptide of the α subunit Gαq.
If approaches could be developed that
specifically target expression of both CCR5 and CXCR4 on CD4 + T cells, virus entry should be inhibited more effectively.
Cellecta's DriverMap ™ service is a novel, comprehensive end - to - end, whole -
genome targeted expression profiling solution intended for research applications.
Our second goal is to
target expression of genetically encoded Ca2 + indicators to specific neuron classes and to monitor Ca2 + signals in behaving animals.
«We introduce a gene that encodes a light - sensitive protein, and
we target the expression of that gene to a subset of retinal cells.»
The lab further developed inhibitors to
target the expression of XBP - 1 and established that blocking the expression of XBP - 1 by specific small - molecule chemical inhibitors can stall malignant progression of leukemia in mice and induce apoptosis in primary human leukemic cells.