Sentences with phrase «target gene delivery»
«It is exciting to have found a way to selectively target gene delivery to cancer cells,» says Quiñones - Hinojosa.
https://www.sciencedaily.com/
Serap Günes (TUD)-- «Modification of vesicular stomatitis virus G protein for targeted gene delivery into PSCA - positive tumor cells» (2007)
Not exact matches
Anderson and others are already exploring new gene - delivery methods, including nanoparticles, to better deliver gene - editing therapies to target tissues.
The photo - clickable miRNAs are able to form functional complexes with target genes upon delivery into cells and target genes associated with the photo - clickable miRNAs could be tagged with molecular handle through photo - click reaction for pull - down and identification.
The advent of molecular cloning, DNA sequencing and the many tools of molecular genetics and cell biology has given us sufficient knowledge of the basis for disease and the genes to target, but what has limited the application of gene therapy has been efficient gene delivery systems.
Asuri, Prashanth, et al. «Directed evolution of adeno - associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.»
To address the editing challenges, we have developed a system that is based on the delivery of recombinant Cas9 protein complexed with an sgRNA targeting the gene of interest (Cas9 / sgRNA ribonucleoproteins [RNPs]-RRB- via cell - derived nanovesicles, called gesicles.
Neurons of the peripheral nervous system (PNS), which connect the heart, lung, gut, and other organs to the CNS, are also an important target for gene delivery, especially for the study of pain.
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
My laboratory has already developed molecules and gene transfer vectors that can target either the MAC, through the delivery of a protein called CD59, or the anaphylatoxins by delivery of proteases, or both by a protein called PRELP.
NGF is in fact viewed as a viable target for AD clinical trials with one group investigating NGF ex vivo gene delivery in a Phase 1 trial with human patients aimed at stimulating cholinergic function and improving memory [123].
We have demonstrated that our liposomes can mediate in vivo target mRNA delivery as well as gene disruption using an entirely RNA - based approach.
Because of their unique properties such as monodispersity, large surface area and high drug loading efficiency, silica nanoparticles (SiNPs) have been developed for a vast array of biomedical uses such as optical imaging, cancer therapy, targeted drug delivery and controlled drug release for genes and proteins.
Sustained high - level expression of human factor IX (hFIX) after liver - targeted delivery of recombinant adeno - associated virus encoding the hFIX gene in rhesus macaques.
Given the tailored inhibition of selected genes and the added precision brought by targeted delivery systems, RNAi - based therapies are thought to carry lower risk of failure than traditional approaches as the biological effects are more predictable.
Remarkably, no matter how the researchers injected the custom - made gene - delivery virus — whether into an artery, intravenously, or directly into muscle — gene expression was limited to the targeted cells.
Their research has focused on multiple scenarios of drugs, including those targeted for gene therapy or chemotherapy, but all rely on the same nanoscale drug delivery mechanism or «nanodepot.»
Particle bombardment, also known as gene - gun or ballistic gene delivery, uses heavy - metal particles to propel naked DNA plasmids into target cells.
Cell - Specific Targeting Strategies for Electroporation - Mediated Gene Delivery in Cells and Animals.
«Our idea is to hone in as much as possible on targets and refine therapies and make everything as focal as possible, both in terms of the genes and proteins as well as the spatial delivery,» she said.
Gene Therapy for Cardiovascular Disease: Advances in Vector Development, Targeting, and Delivery for Clinical Translation.
«Research topics vary from improving corneal wound healing with new proteins to gene delivery targeting retinal disease,» she said.