Sentences with phrase «target gene of interest»

The Guide - it CRISPR / Cas9 Gesicle Production System contains everything you need to easily produce gesicles that will efficiently target your gene of interest.

Vaxwave ® is based on lymphocytic choriomeningitis virus (LCMV) and in this vector the gene encoding the LCMV envelope protein, normally responsible for virus entry into target cells, has been deleted and replaced with a target gene of interest.

The Guide - it CRISPR / Cas9 Gesicle Production System contains everything you need to easily produce gesicles that efficiently target your gene of interest.

To address the editing challenges, we have developed a system that is based on the delivery of recombinant Cas9 protein complexed with an sgRNA targeting the gene of interest (Cas9 / sgRNA ribonucleoproteins [RNPs]-RRB- via cell - derived nanovesicles, called gesicles.

However, the evolution of advanced protein mutants with desired features is strongly dependent on efficiently targeting the gene of interest, the type of selective pressure chosen and the selection scheme allowing recovery of enhanced mutants.

Not exact matches

Women with precancer or cancer were most likely to have particular versions of the viral gene E7, which researchers are now interested in targeting.

The gene, called NPC1L1, is of interest because it is the target of the drug ezetimibe, often prescribed to lower cholesterol.

«What we decided to do was take a completely unbiased approach where instead of targeting individual genes of interest, we would express randomized guides inside of the cell,» Lu says.

Based on a list of about 30 disease - related DNA targets that researchers are interested in altering through gene editing, the researchers made a second list of nearly 3,000 guide RNAs (gRNAs).

The audience will learn about the current state of breast cancer research, how data generated by NGS gene panels target variants of interest and have been developed and used in routine laboratory research, and the broader issues of breast cancer education, awareness, and community services.

Mutalik led the effort to design a set of promoters and RBSs that could be attached to any «gene of interest» such that a bioengineer could be near certain (well, 93 percent sure, but that's near certain in biology) that the protein could be made within an organism to a desired target range.

Uncovering the genetic pathogenesis of Alzheimer's disease has been a target of great interest over the past few years, and genome - wide mapping studies focusing on risk genes have led to significant advances in the field.

He says HGS was getting «diminishing returns» from its investment in TIGR since Venter had steered his outfit into sequencing organisms of little medical importance, and into human genome sequencing, also of limited value for a company like HGS that is interested in genes as drug targets (not untranslated DNA that makes up most of the genome).

Beyond the interest these lateral gene transfers evoke in evolutionary biology, these results highlight the risk gene transfers could cause, in case GM - parasitoid wasps are produced, as genes artificially introduced into wasp species used for biological control could be transferred into the genomes of the targeted pests.

Results of the evaluation of applications for Microinjectionist — Transgenics & Gene Targeting Facility (call of interest of 10/02/2014).

By expressing foreign genes in target cell types, they hope to be able to specifically silence or activate cells of interest.

She is particularly interested in the identification of cancer driver mutations, genes and pathways across tumor types and in the study of their targeted opportunities.

When bred to mice with a cre recombinase gene under the control of a promoter of interest, the STOP sequence of the targeted gene is deleted in the tissue of interest, and EYFP expression is observed.

This modification is of special interest to p53 - dependent anti-senescence and pro-longevity functions because genetically engineered mice with p53 serine18 mutated to alanine (p53S18A) show increased ROS levels, metabolic stress, tumor frequency, premature aging symptoms and defects in regulation of a subset of p53 target genes that include sestrins.

These knockout cell lines allow researchers to quickly validate their gene or target of interest, without having to invest time and resource in developing in - house CRISPR technology.

** If your gene of interest is not listed or is listed above but there is no catalog probe targeting your species of choice, ACD can design and manufacture new probes in 2 weeks.