Sentences with phrase «target gene selection»
Ensuring appropriate target gene selection and maintaining a diversified pre-clinical engine are key aspects of our strategic approach.
http://www.silence-therapeutics.com/ Not exact matches
The target of selection is normally the individual who carries an ensemble of genes of certain kinds.
This and other evidence, say study authors Svante Pbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and his colleagues, «strongly suggest that this gene has been the target of selection during recent human evolution.»
«This is a very easy target for natural selection,» Wrangham argues, because it probably does not depend on numerous mutations but rather on the tweaking of one or two regulatory genes that determine the timing of a whole cascade of developmental events.
Most simply, once these genes, or bits of DNA tied to the genes (known as markers), have been identified, molecular breeders can quickly target offspring inheriting the genes for further development, cutting breeding time and improving the crop's «genetic gain,» the generational improvements made to a crop, like increased height, by human selection.
This week, researchers report identifying some 1800 genes that appear to have been the target of natural selection.
«It is therefore understandable that natural selection may have favored the relative targeting of MMR to genes rather than non-genic regions.
Targets of selection in the Thoroughbred genome contain exercise - relevant gene SNPs associated with elite racecourse performance
We furthermore identified a conservative set of 125 potential domestication targets using four complementary scans for genes that have undergone positive selection.
To further characterize HPP - 4382, we screened a selection of alternative genes for expression: two markers of endoplasmic - or general cellular stress, HSPA6 and GADD45A, and ICAM1, a target of NF - B.
There are genes that, when mutated, cause disorders of language, speech and comprehension, and statistical analyses of our genomes show that these genes were targets of Darwinian natural selection.
Instead, the researchers developed a high - throughput selection assay, CREATE (Cre REcombinase - based AAV Targeted Evolution), that allowed them to test millions of viruses in vivo simultaneously and to identify those that were best at entering the brain and delivering genes to a specific class of brain cells known as astrocytes.
Finally, in order to understand what functions and genes may be targeted by natural selection in the context of OA, genes involved in the initial phases of shell formation in Pacific oyster (Crassostrea gigas) larvae were identified.
Conclusions / significance: Taken together, the microsatellite and both insecticide resistance target - site markers provide evidence that in the face of intense gene flow among populations, disjunction in resistance frequencies arise due to intense local selection pressures despite an absence of insecticidal control interventions targeting Culex.
However, the evolution of advanced protein mutants with desired features is strongly dependent on efficiently targeting the gene of interest, the type of selective pressure chosen and the selection scheme allowing recovery of enhanced mutants.
To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.
Her published work in the area of gene - environment interplay emphasizes the translation of basic research findings to help refine the selection of malleable environmental targets in the context of prevention and intervention studies.