Sentences with phrase «target genes for»

One third of the target genes for which they had patient data - 32 out of 97 - were also linked to survival in women with oestrogen receptor - positive breast cancer, suggesting they play an important role in the disease.

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

Identified eight highly potential target genes for binding by miR -124-3p, genes whose function is also reported to be critical in brain physiology during stress and MDD pathogenesis.

For instance, researchers used virtual screening to identify compounds that target the gene for PFKFB3, an enzyme that helps regulate the metabolism of cancer cells.

Egr3, which belongs to a family of immediate early genes known as early growth response (Egr) genes, is another target gene for BDNF.

Not exact matches

Gene therapy, for example, frequently involves using a virus to deliver a gene to the cells that scientists are targetGene therapy, for example, frequently involves using a virus to deliver a gene to the cells that scientists are targetgene to the cells that scientists are targeting.

The technology's possibilities are staggering — in theory, allowing medical scientists to do everything from cure genetic disorders like sickle cell disease to identify gene targets for combating HIV.

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

In our tests, the Gene Knockout Kit gave us greater than 80 percent knock - out rates for seven targets,» shares Shondra Miller, Ph.D., Director, Center for Advanced Genome Engineering at St. Jude Children's Research Hospital, on Synthego's web site.

«Those carrying the target gene variant slept, on average, for five hours, which was one hour shorter than their twins without the gene.

*** The search for a «gay gene» may be off - target, new research finds.

[The search for a «gay gene» may be off - target, new research finds.

During the dialogue, Dr Gene Nisperos of the Health Alliance for Democracy raised his concern as the target of Golden Rice are members of the vulnerable population such as preschool children and lactating mothers.

That could eventually lead to new drugs that selectively target the gene, which McCarthy says, «could be a strategy for treating mood or sleep disorders.»

«Until recently we have been looking for individual genes associated with diseases, which drug companies then target with treatments.

The researchers also described the full gene repertoires for known drug target families.

Because the genes that are massively amplified in the neochromosomes are essential for the cell's survival, drugs that turn those off are an obvious target for research.

«The extensive overlap in risk genes for autism and cancer, many of which are chromatin remodeling factors, supports the idea of repurposing epigenetic drugs used in cancer treatment as targeted treatments for autism,» said Yan.

In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomes.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

In particular, he has focused on targeting the gene coding for flagellin protein b, or flaB, which has proved to be quite distinct from one genospecies to the next.

The Bill and Melinda Gates Foundation sees so much promise in gene drive technology that it plans to double spending on its Target Malaria initiative, which aims to create systems for driving genes in two species of malaria mosquitoes, to $ 70 million.

Knowing what the master genes are could give scientists targets for new pharmaceuticals to treat brain diseases.

Not surprisingly, MacDougald expects that a gene - targeted treatment for our tubbiness is a long way off.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

If so, the master genes would be even more promising as targets for new treatments.

The finding suggests that other AAVs used for a gene therapy targeting the brain or spinal cord might be improved by having the same or a similar set of amino acids.

Yang said the study not only indicated which genes are affected by traumatic brain injury and linked to serious disease, but also might point to the genes that govern metabolism, cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.

Earlier MD Anderson investigations demonstrated exosomes as a factor in detecting pancreatic cancer, but these latest findings reveal genetically altered exosomes as a potentially novel approach for direct and specific targeting of mutated KRAS, the cancer gene commonly linked to pancreatic cancer.

Parkinson contends that targeted gene replacement produces cells having specific genetic alterations far more effectively than the traditional technique for making transgenic animals, which entails injecting DNA into cell nuclei.

«By greatly narrowing the specific genes involved in social disorders, our findings will help uncover targets for treatment and provide measures by which these and other treatments are successful in alleviating the desperation of autism, anxiety and other disorders,» says Korenberg.

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

«The number of protein functions that are currently targeted by drugs is incredibly small compared to the total number of protein interactions that could be targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's Gene Expression Laboratory.

For comparison, dsRNAs targeting two different genes were tested.

Their «kamikaze» CRISPR system not only disables the target gene, it also disables the gene for the cutting protein after a short delay.

Dwarki and Jaime Escobedo improved the AAV's ability to insert genes into chromosomes by adding a gene promoter region from cytomegalovirus, known to be active in the target for their gene therapy, muscle cells.

The researchers are now investigating the effects of these genes» mutations as possible targets for new therapeutic treatments.

«The trial is important for gene research and may be a proof of principle that targeting the most common mutation in cystic fibrosis is an effective approach for treatment of most patients,» Gentzsch said.

It is typically less expensive to get preselected information about the 20,000 or so genes that make up a person's exome — the section of the genome that provides instructions for making proteins — than to perform a more precision - oriented test that targets a single gene.

If cells were infected with an influenza A mutant lacking NS1, they proceeded to produce large number of the molecular complexes required for RNAi, which include a protein called Argonaute that slices through the target gene.

Bach2, an important gene for inducing memory B cells, may become an important target in vaccine strategies.

The former target, say, using gene editing techniques to inactivate HIV receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).

Unlike whole - genome sequencing, this assay targets a select set of genes or regions with known associations with lymphoid cancer, allowing for more rapid detection of a variety of mutations.

Studying how the knockout mutations affect those traits and health could point to genes that are potentially safe and effective targets for

They identified previously unknown recurrent loss - of - function mutations that target genes regulating epigenetic pathways — ones that act on how tightly or loosely chromosomes are wound and thus accessible for genes to be expressed.

For this study, Dr. Lou and his colleagues focused on triple - negative breast cancer, which is difficult to treat, because it does not exhibit receptors for estrogen, progesterone or the HER - 2 / neu gene, which are targets for many current breast cancer treatmenFor this study, Dr. Lou and his colleagues focused on triple - negative breast cancer, which is difficult to treat, because it does not exhibit receptors for estrogen, progesterone or the HER - 2 / neu gene, which are targets for many current breast cancer treatmenfor estrogen, progesterone or the HER - 2 / neu gene, which are targets for many current breast cancer treatmenfor many current breast cancer treatments.

«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.

«PPM1D is itself a target for drug development, because the gene mutation causes cells to avoid death and proliferate,» Yan said.

The photo - clickable miRNAs are able to form functional complexes with target genes upon delivery into cells and target genes associated with the photo - clickable miRNAs could be tagged with molecular handle through photo - click reaction for pull - down and identification.

The authors conclude that these genes may represent new therapeutic targets for HD.