Sentences with phrase «target genes regulation»

In 2006, she became a Research Fellow at the Hormone Action and Oncogenesis group at the LRBGE and extended her work on GR biology and GR - target genes regulation in response to the ultradian secretion of glucocorticoids occurring naturally in mammalian systems.

Major areas of activity in our lab include 1) identification and characterization of Sgenes, 2) genomic analyses to identify the diversity of TAL effectors in pathogen populations and understand their evolution, and 3) structural and biochemical studies to better harness the unique properties of these proteins for applications such as targeted gene regulation and genome editing.

268/4: 45 Identifying the transcription factors mediating enhancer — target gene regulation in the human genome.

Not exact matches

Four of these potential target genes were significantly down - regulated in the prefrontal cortex of corticosterone - treated rats, and this down - regulation inversely correlated with miR -124-3p levels.

Because RNA carries the genetic message from DNA to the cell's proteinmaking factories, or can directly perform acts such as gene regulation, it, too, is an appealing target for therapies.

Moreover, the ability to easily program sequence - specific DNA targeting and cleavage by CRISPR - Cas components, as demonstrated for Cas9 and Cpf1, allows for the application of CRISPR - Cas components as highly effective tools for genetic engineering and gene regulation in a wide range of eukaryotes and prokaryotes.

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

We are also establishing novel functional strategies, based on targeted and high throughput reporter assays, to assess the relevance of the spatial environment on gene regulation.

Transcriptional regulation information for a gene, including any predicted DNA binding site motifs (YeTFaSCo) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence.

In this study, we also identify p21waf1 / cip1 as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression is linked to the growth - suppressive effect exerted by DDX3 (see Fig. 2).

Of these, SLC24A4 and CACNA1H are potential candidate genes for BP regulation, and the latter is a drug target for a class of calcium channel blockers.

Additionally, we identified p21waf1 / cip1, a cyclin - dependent kinase inhibitor, as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression accounted for the colony - suppressing activity of DDX3.

Helicobacter pylori induces hyperproliferation in a three - dimensional culture system in conjunction with up - regulation of ß - catenin target genes.

For each such peak, they identified genes within 50 kb as potential targets of regulation.

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.

This modification is of special interest to p53 - dependent anti-senescence and pro-longevity functions because genetically engineered mice with p53 serine18 mutated to alanine (p53S18A) show increased ROS levels, metabolic stress, tumor frequency, premature aging symptoms and defects in regulation of a subset of p53 target genes that include sestrins.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

We plan to develop new methods and tools for (1) improving the prediction of TFBSs; (2) predicting TF gene targets; (3) prioritizing cis - regulatory variants dysregulating microRNA transcriptional regulation with downstream impact on the gene regulatory programs in cancer.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Competitive pathway analysis implicated the biological processes of neurogenesis and synaptic regulation, as well as the gene targets of two pharmacologic agents: cinnarizine, a T - type calcium channel blocker, and LY97241, a potassium channel inhibitor.

«Gene therapy, or any treatment that relies on tight regulation of gene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says KarGene therapy, or any treatment that relies on tight regulation of gene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says Kargene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says Karpen.

The immunopurification (IP) of Argonaute (Ago), a central component of the RISC in the human and mouse, followed by microarray analyses (Ago IP / microarray method) makes it possible to isolate any Ago - associated miRNAs and mRNAs without relying on the mechanism of regulation (i.e. mRNA decay or translational suppression), or sequence conservation, enabling a comprehensive identification of the miRNA - target genes in an unbiased manner.

It is accepted that the regulation of adipocytokine secretion or the adipocyte specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.

It is accepted that the regulation of adipocytokine secretion or the adipocyte - specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.