Sentences with phrase «target genes resulted»

In a study published in the journal Cell on July 14, the researchers found that placing enhancers in different positions relative to their target genes resulted in dramatic changes in the frequency of the bursts.

Not exact matches

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

We hoped to be able to do «gene targeting», to introduce genetic changes in animals that would result...

Right now, there is no specific treatment for cancers harboring LKB1 or DIXDC1 alterations, but those with a deletion of either gene would likely see results from cancer drugs that target the focal adhesions, says Shaw.

The results showed that the target of TSY - 1 activity is the TERT gene.

The researchers also hope that by advancing the understanding of which genes play a role in DLB, their results will aid in the development of targeted therapies.

Although an early study, the results offer a new understanding of TRPA1's role in cold exposure and provide impetus for further research into how this gene could be targeted to enhance the body's protective response to cold.

Beyond the interest these lateral gene transfers evoke in evolutionary biology, these results highlight the risk gene transfers could cause, in case GM - parasitoid wasps are produced, as genes artificially introduced into wasp species used for biological control could be transferred into the genomes of the targeted pests.

The results suggest that evolution of resistance in independent populations of killifish converges on the same target gene.

MCR offers an obvious solution to this problem since the incorporation of an anti-malarial gene cassette into an MCR element should result in the rapid spread of the gene cassette through the target population.

Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself.

Also, a different targeting approach leading to the use of the native 3 ′ UTR and removal of the neo gene resulted in normalisation of XpdXPCS mRNA levels and viable homozygous XpdXPCS / XPCS (XPDG602D / G602D) animals [23].

Targeted disruption of IRF - 1 or IRF - 2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.

Results of the evaluation of applications for Microinjectionist — Transgenics & Gene Targeting Facility (call of interest of 10/02/2014).

Critically, gesicles do not result in persistence of the Cas9 endonuclease, which in turn reduces the chances of off - target effects and provides precise control of the dose and timing of gene editing.

The result of this two - step gene modification — forcing expression of the receptor for NY - ESO - 1, and adding a blocker gene to nullify the effect of TGF - beta — is a super T cell engineered to both more effectively kill target cancer cells and to resist the tumor's attack.»

We design short interfering RNA (siRNA) molecules that are able to trigger the RNAi pathway and mediate the degradation of specific target messenger RNAs (mRNAs), resulting in the expression of a particular disease - causing gene being inhibited.

The new knowledge and target candidate genes resulted from such unbiased study are ultimately important for researchers to understand the fundamental nature of stem cell proliferation and differentiation.»

I cross fingers gene therapy is the big one though cautiously optimistic (lackluster fail target results study after study) by way of telomere gene control.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

This is believed to be true given the results of previous RNA - seq experiments (1, 4, 5) along with a belief that the odds are very low that Cas9 would have an off - target that lands in the promoter of another gene, thereby driving aberrant transcription.

«We want to see if these tumors might be selectively sensitive to therapies that target the pathways that are disrupted as a result of these fusion genes,» Baker said.

Our results suggest that HPP - 4382 is a novel activator of the antioxidant response through the modulation of Bach1 binding to the ARE binding site of target genes.

«Preliminary optical coherence tomography [OCT] results from the REVERSE trial indicate that the biological targets of the mitochondrial DNA gene therapy have been successfully engaged in the treated eye compared to the untreated eye.

For GR - targeting drugs, the side effects are thought to come from turning on genes involved in processes such as metabolism and bone growth, while the desired anti-inflammatory effects result mainly from turning inflammatory and immune system genes off.

Moreover, CRISPRi did not result in any off - target changes in gene expression — a commonly cited problem with CRISPR / Cas9.

During periods of oxidative stress, as levels of reactive electrophilic metabolites increase, the ability of Keap1 to target Nrf2 for ubiquitin - dependent degradation is disrupted, thereby increasing Nrf2 protein levels and its transport into the nucleus, resulting in transcription of antioxidant response genes [5], [6], [8], [10], [11].

To exclude the possibility that the results were due to nonspecific effects of this particular STAT6 siRNA, another siRNA targeting the exon 22 sequence of the STAT6 gene (ID # 4689) was utilized.

In this study, we have identified the genomic change in this isolate, and found that targeted deletion of the gene with the change resulted in bacteria with loss of curvature.

The response from Nature Methods concludes by outlining several other whole - genome studies that have been published suggesting CRISPR gene - editing does not result in significant off - target effects.

Results: Target SSTR2 gene expression occurred exclusively in «proinflammatory» M1 macrophages, specific (68) Ga - DOTATATE ligand binding to SST2 receptors occurred in CD68 - positive macrophage - rich carotid plaque regions, and carotid SSTR2 mRNA was highly correlated with in vivo (68) Ga - DOTATATE PET signals (r = 0.89; 95 % confidence interval [CI]: 0.28 to 0.99; p = 0.02).

REST calculates the relative expression ratios on the basis of group means for target genes versus reference genes, and tests the group ratio results for significance, comparing normalized and not - normalized expression results.