Sentences with phrase «target glioma»
«In principle, both these features make GA11 an attractive drug candidate to target glioma stem - like cells in glioblastoma multiforme tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.
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Small numbers of glioma stem - like cells, or GSCs, drive the tumorigenicity of GBM and thus are prime targets for possible treatments.
Nakano says UAB will be the only site in the Deep South for this unique trial aimed at a molecular target in glioma stem cells, a target that is different from the ones described in the Cancer Research paper.
Dario C. Altieri, M.D., Wistar's President and CEO and lead author of the study, and colleagues showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas — a type of brain tumor — and how the pathway could be a valuable therapeutic target in cancer.
Dr. Sloan said that since a single tumor may contain different pools of glioma stem cells, combined targeting should be considered for the pathways and stem cells.
«The field of targeted therapies in gliomas holds a lot of promise, and IL13Rα2 is in an optimal position to materialize these promises,» explained corresponding author Sadhak Sengupta, PhD, assistant professor of neurosurgery at BUSM and principal investigator of the Brain Tumor Lab at Roger Williams.
A research team led by Christine Brown, Ph.D., and a clinical team headed by Behnam Badie, M.D., has received a $ 12.8 million grant from the CIRM to fund a phase 1 chimeric antigen receptor (CAR) T cell trial targeting an aggressive brain cancer called malignant glioma, which includes glioblastoma.
U-M's internationally renowned Translational Neuro - Oncology Laboratory generates novel primary cell cultures from pediatric and adult glioma tissue samples to study mechanisms of glioma growth and targeted treatment response.
Targeted Wnt7a / 7b deletion or pharmacologic Wnt inhibition blocks Olig2 + glioma single - cell vessel co-option and enhances responses to temozolomide.
On their surface, the liposomes are studded with proteins that target receptors on glioma cells.