Sentences with phrase «target key pathways»

Many of these new drugs promise to be more effective because they target key pathways of cancer cells more specifically.

OMP - 54F28 (FZD8 - Fc) and a sister compound also developed by OncoMed, vantictumab (OMP - 18R5), are two of the first therapeutic agents targeting this key pathway to enter clinical testing.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Not exact matches

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

«Molecular scissors» could be key to cutting off diseases including HIV infection: Newly discovered pathway could be drug target, researchers say.»

By giving patients an antibody targeting a key molecule in the inflammatory pathway, investigators reduced heart disease and stroke by 15 %, they reported last week.

Mining that data is critical to developing therapies that target key points in relevant biological pathways — and represents opportunities for bioinformatics experts, Chung says.

Understanding what happens with the UPR in disease is key to illuminating the normal operation of this essential pathway — and to providing insights into the development of targeted therapies.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

The first study used fruit flies as an in vivo test system to reveal new evidence about the function of a key influenza protein called NS1, which has evolved to target molecular pathways in the host.

These findings suggest that the effects of prostaglandin on serotonin signaling are key drivers of the emotional response to pain, implicating a pathway that may be targeted in future therapeutics for managing pain in chronic inflammatory conditions.

But hopes that ageing could be delayed by targeting a single gene or protein in a single molecular pathway have faded, as researchers have learned that the key pathways vary according to the animal.

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).

«Once we can understand what the key pathways are that cause this variability, we can start to think about targeting those pathways, to combat alternate outcomes in cancer treatment, for example.»

Whitehead Institute scientists have at last answered the long - standing question of how the growth - regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine — itself a key player in modulating muscle growth, appetite, and insulin secretion.

Our population approach has enabled us to discover and target key biological pathways involved in conditions ranging from heart attack to cancer.

Postdoctoral fellow Aaron Gitler now is searching for the original defect that the Parkinson's protein triggers in yeast cells in hopes of identifying the underlying disease pathway and key drug targets.

Understanding these pathways, and the identification of the key proteins that control the ability of cancer cells to reprogram their metabolism through biochemical, and epigenetic or genetic alterations that make them resistant to therapies, is of paramount importance for the design of more targeted and therefore less toxic therapies.

Evaluation of these in phenotypic assays has the potential to discover important pathways or targets connected to key pathophysiological processes.

The key biological pathways that are identified will then be targeted therapeutically through rational clinical trial strategies.

The role of new genetic pathways in cancer biochemistry (the genome mutation profiles), the identification of the key targets and their validation, as well as utilization of new knock - out or knock - in animal models for such studies are among topics that will be discussed.

This PI3K - AKT Signaling poster provides an overview of the key molecular targets and their interactions involved in this pathway.

They linked these behaviors to immune pathways, implicating that targeting key components of the immune system could be a new therapeutic strategy for FTD.

By targeting the protein made by a major disease gene, we are in a position to manipulate the key biological pathway involved in the disease.

GSK3β, the first neighbour of β - catenin is a central, highly multi-functional protein known as a key protein difficult to inhibit without causing side effects and toxicity.41 In glioblastoma and NSCLC cancer, previous studies found that the decreased level of FRAT1 influences the GSK3β activity to phosphorylate β - catenin and by that, inhibit the WNT pathway.39, 40 The role of FRAT1 in colon cancer is less known but based on its function in other cancer types and its special influencing position in colon cancer signalling, we point out its relevance as a potential target in colon cancer therapy (Fig. 3d).

BETHESDA, MD, — The Foundation for the National Institutes of Health (FNIH) has selected Whitehead Institute Member David Sabatini to receive its fifth annual Lurie Prize in Biomedical Sciences for discovery of the mTOR (mechanistic target of rapamycin) cellular pathway as a key regulator of growth and metabolism in response to nutrients.

Nrf2 / ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS.

The Diplomás team has identified four key policy areas to target as they work towards the attainment goal: counseling and advising, dual credit, student support pathways, and college affordability.13 P16Plus supports these policy areas using data to help inform those efforts that are most successful for students.

Yes, the key to commercial success is achieving visibility to your target audience; but the pathway to visibility is not necessarily the quantity of one's works.