Sentences with phrase «target late stages»

Not exact matches

Merck is the latest company to weather bad news in the Alzheimer's drug race, halting a late - stage trial yesterday in an experimental amyloid - targeting candidate called verubecestat after a data monitoring committee said there was «virtually no chance of finding a positive clinical effect,» Reuters reported.

Traditionally, companies target angel investors in the early stages of a new business, and later look to venture capitalists, eventually culminating in an initial public offering (IPO) on a stock exchange.

Aligning your co-workers around the need for content marketing and the targets you've set for yourself will only help in collaborating with them for your content creation needs at later stages.

Lilly and Pfizer are co-developing tanezumab, which is in late - stage studies targeting cancer pain, chronic lower back pain, and osteoarthritic pain.

From a global policy perspective, we think the Fed's recent hikes are the first stage in a cycle that will later this year see the European Central Bank (ECB) discuss a more normalized rate policy, and then lastly Japan's BoJ may at least expand its 10 - year Japanese government bond (JGB) yield target range.

Alnylam, which has been weighed down in the past by drug safety concerns, said it plans to initiate a program targeting cardiomyopathy - another symptom of the disease - alongside polyneuropathy in a late - stage study next year.

Third, the Fed should make real the idea that its inflation target is symmetric by being clear that in the late stage of prolonged expansion with low unemployment it is comfortable with inflation rising a little bit above 2 percent with the confidence that it will decline when the next recession comes.

I would hate if we had to start ticking off targets at this late stage.

Group G FYR Macedonia 1 - 2 Spain David Silva and Diego Costa both hit the target for Spain as the Roja kept themselves at the head of the standings on goal difference — though they were given something of a late scare as FYR Macedonia rallied in the closing stages.

CAVD progresses rapidly through multiple, distinct stages of disease, but is general diagnosed late, making it challenging to develop targeted treatments.

«Commonalities in late stages of inherited blinding diseases suggest targets for therapy.»

The gene expression similarities between this common condition and the current findings in late - stage RP suggest that the canine RP models could serve as stand - ins to evaluate the effectiveness of pharmaceutical interventions that target innate immunity pathways in AMD

«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»

Cell - cell interactions are also important in a later stage of neuronal outgrowth when processes grow into the region of their targets.

However, virus strains that can utilize CXCR4 either in place of (X4 HIV) or in addition to CCR5 (R5X4 HIV) are found at significant levels in roughly 50 % of late - stage infected individuals [7], [8], supporting the need for therapies targeted to CXCR4 [9].

If the candidate does not meet these criteria - for example, if it is determined to be ineffective in the target population or if it requires more doses than were predetermined in the TPP - then it will not move forward into later stage trials.

Join the Sibley breast cancer team to learn the latest on breast imaging, chemotherapy and hormonal therapy, Her2 targeted therapy with early stage breast cancer, making sense of breast cancer genetics, demystifying radiation treatment and fertility preservation.

For the later stages of my career, I have been thinking about therapeutic targets and the development of new drugs.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

20 - 30 % of patients with acute myeloid leukemia have mutations of the FLT3 biomarker that make them eligible for several FLT3 - targeted small molecule therapies currently in late stage clinical trials.

Together these analyses represent the discovery phase of our studies on CFS and nPTLS, generating targets for follow up verification and validation in the later stages of the biomarker discovery workflow [13].

Structured Abstract Introduction: The analysis of pharmaceutical industry data indicates that the major reason for drug candidates failing in late stage clinical development is lack of efficacy, with a high proportion of these due to erroneous hypotheses about target to disease linkage.

The stabs made at George W. Bush are amusing only for their inadequacy and irrelevance — surely we've all made up our minds whether he is an idiot or not almost two thirds of the way through his maximum eight years in power, and any satirist hoping to target Bush at this late stage had better have an amazing new slant to get any reaction.

It continued: «screening is not done systematically, and the diagnosis is often made at a late stage when target organ damage has already happened».

This analytical report highlights that while public finance is already playing a significant role in the low carbon sectors, most of the money is targeted at the late - stage construction finance phase once most of the project development risk is removed.

Morgan Stanley Expansion Capital targets later - stage investments in technology, healthcare, consumer, digital media and other high - growth sectors.

The wireless headphone market has been shaken up so much recently that it's hard to know where to begin when a new entry appears on the stage and announces itself as the next big thing.Fortunately this latest Bluetooth offering from Sony is targeting a very specific market segment best referred to as «premium noise cancelation», and the company seems pretty confident that with the MDR - 1000X headphones ($ 400), it has got a hit on its hands.Sony is claiming «industry - leading noise cancelation» with these luxury cans, which use ostensibly the same drivers as last year's highly regarded MDR - 1A headset made for listening to Hi - Res Audio, as supported by the company's audiophilic Walkman range, not to mention its line of wireless home speakers and in - car audio systems.Can it

What happens if you're in late stage interviews with a company about a job and you're asked for your ideal salary target — i.e., name your price?

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