Sentences with phrase «target nanoparticles»

With this type of targeted nanoparticle treatment, the hope is to be able to get rid of that last bit of residual disease, so the cancer can't return.»

«Targeted nanoparticles can overcome drug resistance in trypanosomes: A high - tech approach to combat sleeping sickness and potentially other neglected diseases.»

Whereas in the nematode experiment the researchers targeted nanoparticles to temperature - sensitive ion channels that naturally exist in the membranes of the worms» nerve cells, the scientists inserted the gene for a heat - activated ion channel called TRPV1 into the human and rat cells.

Small molecule MYC inhibitor conjugated to integrin - targeted nanoparticles extends survival in a mouse model of disseminated multiple myeloma.

«With targeted nanoparticles, you have far fewer side effects, so it is anticipated that a drug combination can be selected based on the biology and medicine rather than the limitations of the drugs.»

From an industry perspective, a potential bottleneck that will need to be overcome in bringing targeted nanoparticles from the bench to the bedside is scale - up.

Existing academic laboratory environments are adequate for manufacturing enough targeted nanoparticles for ongoing preclinical studies (in vitro and in vivo).

Research Paper Placenta - specific drug delivery by trophoblast - targeted nanoparticles in mice Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan Theranostics 2018; 8 (10): 2765 - 2781.

However, human studies and clinical use will require far greater quantity of targeted nanoparticles and... more»

The study, conducted by researchers from Colombia University Medical Center (CUMC), Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS), showed for the first time that it is possible to treat inflammation and repair plaques via highly targeted nanoparticles.

Schematic of a targeted nanoparticle with a hydrophilic polymer shell containing targeting ligands and a hydrophobic polymer core containing therapeutic cargo.

Attachment of a peptide to the other end of PEG targets the nanoparticle to a collagen protein found in the vascular basement membrane that becomes exposed with vascular injury and inflammation.

Farokhzad and colleagues have considerable expertise with bench - to - bedside translation of nanotechnologies for medical applications, and foundational work done in part by his team has led to the development and first in human testing of a targeted nanoparticle capable of controlling drug release for treatment of cancers, and the first in human testing of a targeted nanoparticle vaccine capable of orchestrating an immune response to facilitate smoking cessation and relapse prevention.

«The inflammation resolving targeted nanoparticles have shown exciting potential not only for the potential treatment of atherosclerosis as described here, but also other therapeutic areas including wound repair, for example, as described in the Feb. 9 online issue of Journal of Clinical Investigation, in addition to other applications currently underway with our collaborators,» Farokhzad said.

Tumor - targeting nanoparticles loaded with a drug that makes cancer cells more vulnerable to chemotherapy's toxicity could be used to treat an aggressive and often deadly form of endometrial cancer, according to new research...

Not exact matches

Phase I funding — which allows up to $ 250,000 for an academic idea, such as decoding the genetic sequence of a protein or studying targeted drug delivery by using magnetic nanoparticles — is available from federal funding and foundations.

Cambridge, MA — February 6, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that the U.S. Food and Drug Administration (FDA) has cleared the investigational new drug application (IND) for the company's lead program, light - activated AU - 011 in ocular melanoma (OM).

Cambridge, MA — December 21, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it closed a $ 30 million Series C financing.

Cambridge, MA — March 30, 2017 — Aura Biosciences, a biotechnology company developing a new class of therapies to target and selectively destroy cancer cells using viral nanoparticle conjugates, announced today that it has enrolled and dosed the first patient in its Phase 1b clinical trial of light - activated AU - 011, an investigational, first - in - class targeted therapy in development for the treatment of ocular melanoma, a rare and life - threatening disease.

A 17 - year - old California girl won $ 100,000 in a national science competition for her creation of a nanoparticle that can target and kill cancer cells.

Anderson and others are already exploring new gene - delivery methods, including nanoparticles, to better deliver gene - editing therapies to target tissues.

«Now that we have a more complete understanding of this stability, we can better tailor the nanoparticle morphologies and in turn properties, to applications from biolabeling of individual cells and targeted drug delivery to catalytic reactions, thereby creating more efficient and sustainable production processes.»

To find a way to deliver siRNAs for curbing FL2, Dr. Sharp collaborated with Joel Friedman, M.D., Ph.D., professor of physiology & biophysics and of medicine at Einstein, and study co-leader Adam Friedman, M.D., director of dermatologic research at Einstein and Montefiore, who together had developed nanoparticles that protect molecules such as siRNA from being degraded as they ferry the molecules to their intended targets.

These new, non-invasive tools — representing significant advances related to positron emission tomography (PET), 3 - D microscopy and the use of magnetic fields and nanoparticles to remotely control targeted cells...

The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.

Together with his principal investigator (PI), he had realized the commercial potential of modifying nanoparticles with nucleic acids to create targeted, personalized medicines for a myriad of diseases.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

In a paper published in the current online issue of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting,» the researchers report the use of a novel biodegradable and photoluminescent poly (lactic acid) nanoparticle, loaded with melanoma - specific drugs with immune cells as the nanoparticle carriers.

«For years, researchers have focused on delivering more chemotherapy drugs into cancer cells using nanoparticles, without targeting the root of drug resistance,» He said.

Artist's conception of nanoparticle - carrying immune cells that target tumors and release drug - loaded nanoparticles for cancer treatment.

To address this challenge, our research group is using nanoparticles not only to deliver more chemotherapy drugs to the target site within cancer cells, but also to compromise the function of the efflux pumps and thereby significantly improve safety and efficacy of cancer therapy.»

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

Lanza also designed the nanoparticles to carry targeting molecules that home in on and bind to cancer cells that carry the complementary receptor, like a lock and key.

Delivering these compounds in a nanoparticle, says Merlin's team, may be a more effective way to target colon tissue than simply providing the herb as a food or supplement.

The «target» cells on the other side of the BeWo barrier to the nanoparticles were human fibroblast cells, found in skin and connective tissue.

Now, a new type of nanoparticle, described in PLOS Neglected Tropical Diseases, effectively vaccinated mice against one of the serotypes and could be created to target all four.

The investigators utilized a targeting method called RNA interference (RNAi) which, when delivered via these natural nanoparticles or exosomes, zero in on mutant KRAS in pancreas cancer cells, impacting tumor burden and survival in multiple pancreas cancer models.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

A technique using anesthesia - containing nanoparticles — drawn to the targeted area of the body by magnets — could one day provide a useful alternative to nerve block for local anesthesia in patients, suggests an experimental study in the April issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

Magnet - directed nanoparticles have previously been used for targeted delivery of chemotherapy drugs.

A DNA array detection method is reported in which the binding of oligonucleotides functionalized with gold nanoparticles leads to conductivity changes associated with target - probe binding events.

To validate their findings, the scientists injected the novel nanoparticles into pancreatic tumor - bearing mice and observed that by balancing these two targets — bringing them to a normal level by increasing their expression or blocking the gene responsible for their expression — they significantly prolonged the survival of the mice.

This allows the researchers to track the progress of the nanoparticle into the cancer cell to insure that it is in its target before light activation.

Using nanoparticles designed and screened for endothelial delivery of short strands of RNA called siRNA, the researchers were able to target RNAi to endothelial cells, which form the linings of most organs.

Up to this point, researchers have gotten the best results with RNAi targeted to diseases of the liver, in part because it is a natural destination for nanoparticles.

The core nanoparticle, only 13 nanometers in diameter, enters cells, and the NanoFlare seeks its target.

His research group will also work on targeted delivery of the drug using their patent pending «nanobowls,» which are magnetically guided nanoparticles that can be packed with drugs and diagnostic molecules, deliver them to particular sites in the body and release them on demand.

To develop subunit vaccines for other diseases, scientists have tried targeting them to lymph nodes using nanoparticles to deliver them, or tagging them with antibodies specific to immune cells in the lymph nodes.

The light - sensitive cells and nanoparticles, called opto - CRAC, were then delivered with the tumor antigen surrogate ovalbumin to mice with melanoma tumors in their lymph nodes to see if an immune response could be activated to target cancer cells.

To make the approach feasible in humans, researchers need to design nanoparticles that are «very, very selective» in their ability to target specific brain structures and neurons, Sastre says.