Thus, repeated or prolonged exposure to the substance can produce
target organs damage.
A recent observational study investigating sex differences in
target organ damage, in insulin - resistant patients, demonstrated increased vascular and renal damage in women, who had increased intima - media thickness progression, higher numbers of vascular plaques, and reduced pulse wave velocity compared with men (321).
Gender differences in the progression of
target organ damage in patients with increased insulin resistance: the LOD - DIABETES study
According to some sources, prolonged / repeated exposure can cause
target organ damage.
It continued: «screening is not done systematically, and the diagnosis is often made at a late stage when
target organ damage has already happened».
Not exact matches
Drinking too much alcohol can
damage the liver, but investigators have discovered a protective response in the
organ that might be
targeted to help treat alcoholic liver disease.
We performed histological examination of GVHD
target organs (liver, lung, small intestine, and colon) and the tongue, which served as a surrogate for skin
damage (37), 4 wk after transplantation.
These syndromes include conditions in which autoimmunity is clearly implicated as causal, in light of identification of autoantibodies to relevant autoantigens; diseases suspected to be autoimmune because of the presence of autoantibodies, although the autoreactive response has not been proven to be pathogenic and could be a consequence or marker of tissue
damage; and other diseases often considered to be «autoimmune,» such as psoriasis or inflammatory bowel disease, characterized by
organ -
targeted inflammation but without evidence of a stimulating autoantigen.
Therapy using live cells is increasingly used to replace
damaged tissue, deliver gene therapies to
target tissues and
organs, and stimulate self - healing along with a number of other applications.