Sentences with phrase «target other cancer cells»

Finally, the researchers showed that the circuit could be readily converted to target other cancer cells.

Not exact matches

As researchers learn more about genetic profile of various cancers, other work is charging ahead to deliver personalized vaccines targeted to a patient's own tumor cells

Other CAR - T cells that were tuned to different molecular targets also did not kill the DIPG cancer cells.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

By combining this strategy with cancer cell - targeting materials, we should be able to develop a therapy for glioblastoma and other challenging cancers in the future.»

Targeted cancer treatments are designed to attack molecules produced by mutations, but if the targeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant cellsTargeted cancer treatments are designed to attack molecules produced by mutations, but if the targeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant cellstargeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant cells spread.

According to Radu, «this new dual targeting approach shows that we can overcome the redundancy in DNA synthesis in ALL cells and identifies a potential target for metabolic intervention in ALL, and possibly in other hematological cancers.»

Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

In other words, the same «old» medicine simultaneously targets the cancer cells themselves and the blood vessels with great efficiency.

The findings, published in the journal Cell Reports, provide new insight into how melanoma grows and identifies a new target for treatment of melanoma and other cancers.

Because some of these neighbour proteins are as central and as global as the cancer - related proteins themselves, and link to so many other processes in the cell, there's a strong likelihood that drugs targeting them may have strong side - effects.

The findings, which were published online in the journal Cancer Cell, could ultimately lead to new targeted therapies for many other types of cancer carrying similar p53 mutaCancer Cell, could ultimately lead to new targeted therapies for many other types of cancer carrying similar p53 mutacancer carrying similar p53 mutations.

When McKnight was research director at Tularik, which is targeting cancer and other diseases with drugs that alter the cell's production of specific proteins, he spent 30 % to 40 % of his time scraping together dollars.

What if drugs for cancer, cardiovascular disease, and other diseases can be targeted specifically and only to cells that need the medicine, and leave normal tissues untouched?

Depending on the dose and the target, radiation can cause incredible damage to healthy cells or it can be used to treat cancer and other diseases.

The results of this original study are highly relevant to other human diseases that dependent on genome instability, such as fungal infection or cancer, and open new venues for anti-leishmanial drug discovery using host - directed strategies that target the parasite's metabolic dependence on the host cell, thus preventing the adaptive evolution of drug resistant parasites.

But he believes that targeting cancers for destruction by necrosis and not by apoptosis, the other main pathway to cell death, holds great promise therapeutically.

She also noted the targeting Msi in primary tumors significantly changed «the trajectory of progression by halting pancreatic cancer growth and improving survival,» inhibiting both cancer stem cells and other tumor cells.

The treatment is promising enough that research teams around the world are developing similar stem cell therapies that can target and eradicate cancers of the prostate, lung, breast, skin and other tissues.

One treatment is a vaccine that targets a structure on the outside of cancer cells, while the other is an altered enzyme that breaks apart RNA and causes the cell to commit suicide.

Other blood disorders that have shown significant benefit from targeted gene therapy in small trials include hemophilia (specifically, factor IX deficiency), severe beta - thalassemia (deficiency for the adult beta - globin gene) and leukemia, where the patient's immune cells were treated to enable them to recognize cancer cells and destroy them.

Several antibody drugs have been developed to target other receptors found on cancer - cell surfaces.

He hopes the cancer - targeting nanorobots will steer clear of other rapidly dividing cells, such as those in the gut and at hair follicles, which often suffer collateral damage during chemotherapy.

But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance.

It remains now to investigate whether this novel secretory route may be exploited by other specialized cells, or targeted in pigmentary disorders or skin cancers like melanoma.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

The iPSCs eventually turned into fully active, cancer - specific T - lymphocytes - in other words, cells that target and destroy cancer cells.

These drugs can be targeted to interfere with signalling within the tumour microenvironment or activate other processes which will kill the cancer cells.

On the other hand, first clinical trials with drugs designed to target cancer stem cells are now under way, so far yielding moderately positive results.

Their findings on telomeres, the stretches of DNA at the ends of chromosomes that protect our genetic code and make it possible for cells to divide, suggest a potential target for preventive measures against cancer, aging and other diseases.

Unlike other studies on p53, however, which target cell populations that average many cells together, Dr. Lahav developed a new approach, quantifying p53 at high temporal resolution in single cells and taking into account that «individual cell decisions are crucial in the development and treatment of cancer.»

Targeted therapy is a treatment that uses drugs or other substances to identify and attack specific cancer cells without harming normal cells.

The results of her project will help scientists develop novel therapies to target the regulatory proteins that cause CD47 overproduction in leukemia and other cancer stem cells, with the goal of restoring immunosurveillance and enabling the immune system to recognize and destroy these aberrant cancer cells.

AXL mediates resistance to TRAIL - induced cell death in esophageal adenocarcinoma (55); it remains to be determined whether ABL - mediated protection from TRAIL - induced apoptosis in breast cancer cells is mediated by AXL or other targets.

Immune Design is a clinical - stage biotechnology company made up of collaborative, «can do», experienced professionals passionate about leveraging the company's leading - edge technologies that target dendritic cells for a more precise immune response for the treatment of cancer and other chronic conditions.

However, we can not rule out the possibility that ABL kinases might regulate YAP1 - mediated expression of other target genes in breast cancer cells.

Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies.

The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

Curcumin decreases inflammation and other dangerous cancer signals that aggravate cells (see figure Curcumin Targets).

Other studies have examined other natural plant extracts with anti-cancer activity such as garlic, broccoli, raspberries, blueberries, carrots, ginger, onions and others and they all have been identified as having the ability to target cancer cOther studies have examined other natural plant extracts with anti-cancer activity such as garlic, broccoli, raspberries, blueberries, carrots, ginger, onions and others and they all have been identified as having the ability to target cancer cother natural plant extracts with anti-cancer activity such as garlic, broccoli, raspberries, blueberries, carrots, ginger, onions and others and they all have been identified as having the ability to target cancer cells.

Some of these treatments such as Gerson Therapy work to strengthen and balance the immune system and take some time to be effective while other treatments, such as High Dose Vitamin C intravenous therapy, target cancer cells safely and work right away to decrease tumor load, allowing time for the nutritional program to work.

The company's antibody - based product candidates target a number of potential indications including AL and AA forms of amyloidosis, Parkinson's disease and other related synucleinopathies and novel cell adhesion targets involved in inflammatory diseases and cancers.