Sentences with phrase «target plasma cells»

Not exact matches

Target detectability data from 858 samples from 11 independent customer sites, utilizing five unique sample types: serum, plasma, cell culture supernatant, lysates, and bronchoalveolar lavage.

The extracellular leaflet of the plasma membrane is not characterized by unique molecular targets but by overexpressed antigens that are relatively down regulated in healthy cells.

Tissues being sampled include biopsy material from target organs, peripheral blood cells and serum / plasma, germline DNA, and stool for microbiota analysis.

Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma - membrane - targeted Rab5 on clathrin - dependent endocytosis.

Nonthermal plasma needle: development and targeting of melanoma cells.

Several types of targeted therapy may be used to treat multiple myeloma and other plasma cell neoplasms.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

This force is predicted to operate between manufactured nanoparticles providing they are sufficiently rigid and tightly bound to the plasma membrane, thereby suggesting a route for the targeting of nanoparticles to cells for biomedical applications.

Rothman immediately realised the importance of the result, and proposed the «SNARE hypothesis» for vesicle transport and exocytosis as a general process in all cell types: vesicle proteins specifically bind to target proteins in the plasma membrane to form a «v - t» complex which is necessary for vesicle and membrane fusion to proceed.

In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with autoantibodies targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of autoantibodies.

Heavy metal accumulation by Saccharomyces cerevisiae cells armed with metal binding hexapeptides targeted to the inner face of the plasma membrane — Lavinia Liliana Ruta — Applied Microbiology and Biotechnology

The overall goal of IV Nutritional Therapy is to achieve blood plasma nutrient concentrations not obtainable by oral supplement administration to achieve health optimization and to directly target diseased or nutritionally deficient cells / organs / tissues of the body.