The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of
target protein coding genes.
In addition, profiling has been exploited to identify non-coding RNAs that may represent downstream targets of activated oncogenic pathways or that are
targeting protein coding genes involved in cancer.
Not exact matches
In particular, he has focused on
targeting the
gene coding for flagellin
protein b, or flaB, which has proved to be quite distinct from one genospecies to the next.
The
gene that
codes for this clotting
protein has a very similar sequence across many plant species, and the researchers showed that the microRNA from dodder
targets regions of the
gene sequence that are the most highly conserved across plants.
Extensive research has already examined the function of microRNAs, a category of small evolutionarily conserved noncoding RNAs about 22 to 24 nucleotides in length that
target protein -
coding genes in a sequence - specific manner.
If so, it could make cell fate more resilient to random mutations in a plant's genetic
code, even when such changes keep some
gene - regulating
proteins from binding their intended DNA
targets.
By acquiring sections of
proteins coded by other
genes, which are often the
target of pathogen infection, NLRs act as an «integrated defense decoy».
TKM - 080301
targets a specific
gene called polo - like kinase 1 (PLK1), which
codes for a
protein involved in tumor cell growth.
But Yang
targeted several
genes that
code for the
protein that causes mushrooms to turn brown as they age or get bruised.
Until now, the vast majority of CRISPR screens have
targeted protein -
coding genes.