Sentences with phrase «target receptor»

One of the viral genes, env, specifies a protein that forms the viral envelope, the outer covering of the virus that interacts with a target receptor on the surface of lung cells.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

In principle, he says, a drug developed to target this receptor could stimulate the growth of new spines, with possible implications for altering libido in humans.

Like many drugs, beta blockers target receptors embedded in the surface of cells.

By understanding how the body's natural hormones operate, they aim to develop synthetic compounds to target these receptors in order to create drugs to treat diseases.

For the investigation at the X-ray laser, the researchers grew tiny crystals of the serotonin receptor with the molecule ergotamine attached, which is a migraine drug that targets this receptor.

Inglis attributes this success to the fact that the bacteriocin targets a receptor on the bacteria's cell surface that is essential to its survival.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

Targeting receptor 2, Dawson identified a chemical that reduced a mouse's startle response — a measure of anxiety — without impairing its ability to balance atop a rotating rod.

Since adiponectin binds to two receptors, AdipoR1 and AdipoR2, Yokoyama, who leads the RIKEN Structural Biology Laboratory, and his team surmised that understanding how this binding takes place could contribute to the creation of drugs that target these receptors.

The trouble is that drugs targeting these receptors can have bad side effects.

The new findings that coupling mechanisms and the receptor are important for keeping the balance may explain why common anti-tumor treatments targeting the receptor have heavy side effects for the skin.

In fact, large human liver cancer tumors on comparatively small mice started regressing about 20 days after treatment, and were eradicated by day 41 with the help of one of the targeted receptors.

Recently, there has been progress in the treatment of patients with malignancy through targeting receptors on the surface of CD8 + T cells that inhibit their activity within the highly suppressive tumor microenvironment.

When an LDL particle (carrying cholesterol) binds to the LDLR, the particle is trafficked into the hepatocyte, and PCSK9 targets the receptor for lysosomal degradation.

In the latter area, more than 50 % of drug discovery screens use cell ‑ based assays, predominantly targeting receptors and ion channels using fluorescence ‑ based measurements, in either or both high throughput and high ‑ content formats (1).

Although nearly a third of modern medicines work by targeting receptors that signal via G - proteins, researchers have not had very good tools for studying the signaling pathways that run downstream of G - proteins.

On their surface, the liposomes are studded with proteins that target receptors on glioma cells.

The finding had therapeutic implications, since targeting this receptor - hormone interaction could be used for either contraceptive or fertility treatments.

Not only is this a novel way to study basic biological mechanisms of these commonly targeted receptors inside the brain and individual neurons, but it's also a tool scientists can use to study specific effects of drugs in various regions of the brain.

Experts at the University of Pennsylvania eventually identified the mysterious antibody as a type that targets receptors in the central nervous system that are involved in memory and neuron function.

Direct — this occurs when growth hormone binds to its targeted receptor cells to create an action or effect

Specifically, it targets receptors in the body to increase muscle mass and bone density.

Its small molecule drug conjugates are actively target receptors that are over-expressed on diseased cells.

«In the near future, we'll likely see more medications specifically targeting receptors on cells involved in allergic reactions, such as tyrosine kinase inhibitors (mast cells), for dermatologic use.»

«Establishing an animal model is paramount for testing new treatment and prevention modalities, especially for lesions that express none of the targeted receptors, such as triple - negative types, before human clinical trials,» Mohammed said.

Not exact matches

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

Triple negative breast cancer is especially hard to treat because it lacks the receptors, such as the estrogen receptor, targeted with other cancer drugs.

At a meeting last month just outside Boston, chemists and biologists discussed the promise of DNA - encoded chemical libraries (DELs), which rely on the unique talents of DNA to track, select, and even synthesize compounds that bind to enzymes, receptors, and other biological targets.

Eukaryotic - specific signal recognition particle and receptor components stabilize the ribosomal endoplasmic reticulum — targeting complex.

The team was successful in getting the drug to piggyback on 123B9, an agent they devised to target an oncogene called EphA2 (ephrin type - A receptor 2).

The m2R receptors therefore are a new potential target for treating the disease, Hart said.

«Molecular secrets revealed: Antipsychotic docked in its receptor: Discovery may lead to safer, more targeted drugs.»

CAR T cells target and kill cancer cells via bioengineered T - cell receptors.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

Her group is also collaborating with a team of medicinal chemists to look for compounds that target only the alpha version of the retinoic acid receptor.

Peptides can bind to targets on a cell (usually receptors or enzymes that are themselves proteins) and so regulate cellular functions such as nutrient uptake or communication between cells.

Chen believes that dual - receptor targeting tracers could one day be the primary method for diagnosing and monitoring prostate cancer reducing the amount of medical scans a patient would be forced to undergo and streamlining the diagnostic and therapeutic process.

Each epitope is targeted by a pool of T cells bearing different, but specific, T cell receptors to recognize and respond.

Previous tracers have targeted GRPR but this new tracer is one of the first dual - receptor target tracers, or tracers that target more than one biomarker, to be studied in humans.

Various companies are also testing a class of drugs that target both IGF - 1R and the insulin receptor.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

This new tracer targets two biomarkers, gastrin - releasing peptide receptor (GRPR) and integrin αvβ3, that often indicate prostate cancer.

Beta blockers target beta receptors, which respond to the «fight or flight» hormones adrenalin and noradrenalin.

The latest therapy to flop, called ganitumab, is a monoclonal antibody that targets type 1 insulin - like growth factor receptor (IGF - 1R).

The largest class of human target proteins for drugs are the so - called G - protein - coupled receptors.

Both this molecule and its receptor in the bone marrow could be targeted to prevent the inflammation that occurs with type 1 diabetes,» says co-senior author Dr. Ira Goldberg of Columbia University College of Physician & Surgeons in New York City.

The SNARE (soluble N - ethylmaleimide — sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v --RRB- SNAREs and target membrane (t --RRB- SNAREs interact specifically to control and mediate intracellular membrane fusion events.