Not exact matches
«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only
target terminally differentiated cancer cells and thus can only reduce the bulk of the
tumor,» said Jamieson, who is also deputy director of the Sanford
Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Hea
Stem Cell Clinical Center, director of the CIRM Alpha
Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Hea
Stem Cell Clinic at UC San Diego and director of
stem cell research at Moores Cancer Center at UC San Diego Hea
stem cell research at Moores Cancer Center at UC San Diego Health.
«Our work strongly supports that cancer
stem cells are the main source of growth in these
tumors and, as such, should be considered promising
targets for treatment,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology, co-senior author of the Nature paper.
The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma
stem cells from more differentiated
tumor cells and to suggest potential therapies
targeting those factors.
«In order to block
tumor recurrence after radiation therapy, we used an antibody to
target and inhibit these cancer
stem cells,» said Dr. Xu.
Rare
stem - like
tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to
target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.
There's a need for ways to find these cells and to study them, and importantly, to develop drugs that
target them, because these cancer
stem cells are resistant to chemotherapy drugs that
target the main
tumor.
«In principle, both these features make GA11 an attractive drug candidate to
target glioma
stem - like cells in glioblastoma multiforme
tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.
She also noted the
targeting Msi in primary
tumors significantly changed «the trajectory of progression by halting pancreatic cancer growth and improving survival,» inhibiting both cancer
stem cells and other
tumor cells.
Targeting cancer
stem cells may be important for complete
tumor remission.»
A vaccine that
targets cancer
stem cells dramatically limits
tumor growth in mice, researchers reported in April.
Dr. Sloan said that since a single
tumor may contain different pools of glioma
stem cells, combined
targeting should be considered for the pathways and
stem cells.
«Our results are the first to provide insight into ways of
targeting multiple brain metastatic deposits with
stem - cell - loaded oncolytic viruses that specifically kill dividing
tumor cells.»
Researchers studying the heterogeneous nature of cancer
stem cell - containing skin
tumors may have discovered new therapeutic
targets
Finally, his discussion covers the genetic manipulation of induced pluripotent
stem cells (iPSCs) to derive NK cells engineered to express modified CD16A, and their potential for improving the efficacy of
tumor -
targeting therapeutic mAbs.
Non-virally engineered human adipose mesenchymal
stem cells produce BMP4,
target brain
tumors, and extend survival.
Transplanting non-cardiac
stem cells also increases the risk for
tumor formation, as many of the cells turn into other cell types besides the
target heart cells.
Antibiotics that
target mitochondria effectively eradicate cancer
stem cells, across multiple
tumor types: treating cancer like an infectious disease.
Endothelial progenitor cells derived from induced pluripotent
stem cells which
target tumors can be modified to carry an anti-tumorigenic «payload» and promoter
tumor growth inhibitionsy
In fact, it is thought that common chemotherapies,
targeting the fast - dividing cells, leave the relatively slow - dividing
tumor stem cells unharmed and thus pave the way for an eventual relapse.
Her goal is to define the molecular architecture and functional significance of a niche, determine how
tumor growth impacts the niche, learn how benign and malignant cells compete within a niche, and use this knowledge to design precisely
targeted anti-cancer treatments that spare normal bone marrow and improve the efficacy of
stem cell - based therapies.
It is unlikely that one  therapeutic agent will be able to
target the cancer
stem cells in for example all types brain
tumors.
In order for
stem cell
targeting of antibodies to be clinically relevant, immunoglobulin - secreting NSCs must retain their migratory
tumor - tropic properties.
Cancer
stem cells make up for 0.2 to 1 % of all the cells in a
tumor, but
targeting them is extremely difficult.
Cancer
stem cells (CSCs) have become an important
target in cancer therapy and prevention due to their ability to self - renew, initiate
tumors, and resist therapy.
Traditional treatments typically
target tumors but leave the
stem cells behind, making them more aggressive and allowing them to rebuild the
tumor rapidly.