Sentences with phrase «target tumor stem cells»

Not exact matches

«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaStem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaStem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Heastem cell research at Moores Cancer Center at UC San Diego Heacell research at Moores Cancer Center at UC San Diego Health.

«Our work strongly supports that cancer stem cells are the main source of growth in these tumors and, as such, should be considered promising targets for treatment,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology, co-senior author of the Nature paper.

The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.

«In order to block tumor recurrence after radiation therapy, we used an antibody to target and inhibit these cancer stem cells,» said Dr. Xu.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

There's a need for ways to find these cells and to study them, and importantly, to develop drugs that target them, because these cancer stem cells are resistant to chemotherapy drugs that target the main tumor.

«In principle, both these features make GA11 an attractive drug candidate to target glioma stem - like cells in glioblastoma multiforme tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.

She also noted the targeting Msi in primary tumors significantly changed «the trajectory of progression by halting pancreatic cancer growth and improving survival,» inhibiting both cancer stem cells and other tumor cells.

Targeting cancer stem cells may be important for complete tumor remission.»

A vaccine that targets cancer stem cells dramatically limits tumor growth in mice, researchers reported in April.

Dr. Sloan said that since a single tumor may contain different pools of glioma stem cells, combined targeting should be considered for the pathways and stem cells.

«Our results are the first to provide insight into ways of targeting multiple brain metastatic deposits with stem - cell - loaded oncolytic viruses that specifically kill dividing tumor cells.»

Researchers studying the heterogeneous nature of cancer stem cell - containing skin tumors may have discovered new therapeutic targets

Finally, his discussion covers the genetic manipulation of induced pluripotent stem cells (iPSCs) to derive NK cells engineered to express modified CD16A, and their potential for improving the efficacy of tumor - targeting therapeutic mAbs.

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Transplanting non-cardiac stem cells also increases the risk for tumor formation, as many of the cells turn into other cell types besides the target heart cells.

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease.

Endothelial progenitor cells derived from induced pluripotent stem cells which target tumors can be modified to carry an anti-tumorigenic «payload» and promoter tumor growth inhibitionsy

In fact, it is thought that common chemotherapies, targeting the fast - dividing cells, leave the relatively slow - dividing tumor stem cells unharmed and thus pave the way for an eventual relapse.

Her goal is to define the molecular architecture and functional significance of a niche, determine how tumor growth impacts the niche, learn how benign and malignant cells compete within a niche, and use this knowledge to design precisely targeted anti-cancer treatments that spare normal bone marrow and improve the efficacy of stem cell - based therapies.

It is unlikely that one  therapeutic agent will be able to target the cancer stem cells in for example all types brain tumors.

In order for stem cell targeting of antibodies to be clinically relevant, immunoglobulin - secreting NSCs must retain their migratory tumor - tropic properties.

Cancer stem cells make up for 0.2 to 1 % of all the cells in a tumor, but targeting them is extremely difficult.

Cancer stem cells (CSCs) have become an important target in cancer therapy and prevention due to their ability to self - renew, initiate tumors, and resist therapy.

Traditional treatments typically target tumors but leave the stem cells behind, making them more aggressive and allowing them to rebuild the tumor rapidly.