Sentences with phrase «target tumor tissue»

For example, knowing that IL - 37 helps to create overall immune system sensitivity could allow researchers to manipulate IL - 37 levels to sensitize the immune system to recognize and target tumor tissue, or desensitize the immune system in auto - immune conditions like rheumatoid arthritis in which the immune system acts over-aggressively toward healthy tissue.

Not exact matches

Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.

These responses should target only tumors and not normal tissues, resulting in low toxicity.

For example, an MDM2 - targeting drug shrank deep - tissue fat cell tumors in just one out of 20 patients in a phase I safety trial, published in 2012.

Researchers said the importance of collecting tissue samples from recurrent tumors will grow as more targeted therapies become available.

The advantage of proton therapy is that there may be a procedure I could undergo in the future that uses targeted radiation to target the tumorous tissue and that could potentially kill off my tumor.

Because those organoids include stroma, a scaffold of connective tissue essential for tumor growth, they may prove better for studying therapies that target the stroma, such as cancer immunotherapy.

But our «taxi» kept the «passengers» — and the rest of the body — safe the whole way, targeting only the tumor tissue.

Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.

Therapeutics targeted to tumors, for example, should be delivered only to the tumor and not to surrounding tissues.

Keytruda is the first approved drug that targets tumors with specific biomarkers, rather than based solely on their tissue origin (i.e. breast, lung, or colon).

It is likely that a similar mechanism operates during cancer invasion, which suggests a promising alternative in which cancer treatments might work in the future, if therapies can be targeted to limit the tissue fluidity of tumors.

Importantly, without any prior knowledge from the analysis of tumor tissue, 76 % of «actionable» mutations (genetic changes that can be matched to an approved targeted therapy or one being tested in clinical trials) detected in tissue were also detected in blood.

In their search for novel, tumor - specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed a mouse model that more closely mimics what is seen in patients.

According to McKenna, this makes it a prime target for anti-cancer drugs that would cause little or no side effects to healthy tissue surrounding the tumor.

As the irradiated area is smaller, the drug delivery is confined to the targeted area, resulting in less damage to healthy tissue surrounding the tumor.

The findings, published online the week of March 21 in the journal Proceedings of the National Academy of Sciences, demonstrate that nanoparticle - based therapies can act as a «precision medicine» for targeting tumors while leaving healthy tissue intact.

A team of researchers led by Caltech scientists has shown that nanoparticles can function to target tumors while avoiding adjacent healthy tissue in human cancer patients.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

New and innovative technology would use radiation beams to target tumors and leave healthy tissue intact.

With highly precise image - guided treatment delivery, we can target the radiation on the tumor and avoid healthy tissue more successfully than ever before.

The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects.

The targeted drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues by linking it to tumor - targeting moiety.

Other radiation treatments that require targeting the tumor from an external source, which exposes healthy tissues and limits how high a dose can be safely delivered.

«To our knowledge, this is the first naked RNA nanoparticles to have been comprehensively examined pharmacologically in vivo and demonstrated to be safe, as well as deliver itself to tumor tissues by a specific targeting mechanism,» he says.

The Center for Cancer Targeted Therapies (C2T2) integrates a phase I - Ib / early clinical trials program, a precision cancer medicine infrastructure with expertise on tumor tissue - based state - of - the - art molecular methods, and a core resource with novel non-invasive functional imaging methods.

This includes the generation of animal models containing patient - derived tumor tissue to evaluate the sensitivity of genomically targeted drugs.

«Therefore,» the authors wrote, «FABP4 emerges as an excellent target in the treatment of intra-abdominally disseminating tumors, which preferentially metastasize to adipose tissue such as ovarian, gastric, and colon cancers.»

Because viruses have evolved such effective methods for finding their target and utilizing the host cells» own molecular machinery, scientists are modifying viruses into long - lasting therapeutic vehicles that can deliver drugs to specific cells or tissues or selectively target and destroy tumors.

Because the tumor specificity of NSC - mediated immunotherapy is endowed by the NSCs, antigens on tumor cells can likely be safely targeted, regardless of whether they are present in healthy tissues.

The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues.

The spice targets only cancerous cells causing them to self - destruct by destroying the mitochondria that power the rapidly growing tumor tissue.

The linear accelerator (LINAC) uses high energy targeted x-ray beams to treat many types of cancer, including nasal tumors, oral tumors, soft tissue sarcomas, and brain tumors.

The robotic arm allows movement around the animal in order to target a tumor and spare normal surrounding tissue.

At UW Veterinary Care, we have a TomoTherapy radiation delivery system which targets radiation to the tumor while sparing the surrounding normal tissues from side effects.