Sentences with phrase «target validation studies»

Not exact matches

The Institute's phenotyping platforms are adapted for the study of mutant mice and genetic reference populations but can also be used for preclinical studies including the validation of therapeutic targets as well as pharmacological and toxicological studies in the mouse.

We are now extending the previous metabolomics genetics studies to inform drug development in a project funded by the Center for Therapeutic Target Validation.

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

The role of new genetic pathways in cancer biochemistry (the genome mutation profiles), the identification of the key targets and their validation, as well as utilization of new knock - out or knock - in animal models for such studies are among topics that will be discussed.

The expertise displayed by the teams and the platforms of the Department of Translational Research allows the support for maturation of translational research projects (proof of concept in vivo, target / biomarker identification and validation, ancillary biological studies coupled to clinical trials,...) of the Institut Curie alone or in collaboration with other academic teams or industrial partners.

These analyses represent a discovery phase of our studies on CFS and nPTLS, generating targets which can be followed up in future verification and validation stages studies [13].

This is in contrast to subsequent validation studies where targeted approaches are used and which do require knowledge of target proteins.

Together these analyses represent the discovery phase of our studies on CFS and nPTLS, generating targets for follow up verification and validation in the later stages of the biomarker discovery workflow [13].

These laboratories are complemented by several additional laboratories: one that is focused on computational structure prediction and design (Phil Bradley), one that conducts solution - based protein mapping studies of large complexes involved in gene transcription (Steve Hahn) and a third that conducts drug target validation and drug screening studies (Julian Simon).

Validation studies and resulting documentation within the Ozone CCI will address the following targets:

As a supplement to APT Validation Study II, the research aims for Validation Study III are to (1) generate master scores for video clips of youth program observations without cultural bias, (2) create more tailored and targeted online training and anchor systems, and (3) eliminate significant differences in certification passing rates between groups with different cultural vantage points (i.e., Black vs. White raters, urban vs. non-urban program experiences).