Sentences with phrase «targeted against tumor»
In this system, the dendritic cells are activated and targeted against tumor cells while remaining inside the patient's body.
https://www.sciencedaily.com/ Not exact matches
The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.
«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»
Drugs that targeted the RAS pathway showed little activity against the tumor cells.
It is also a whole - tumor vaccine, meant to stimulate an immune response against not just one tumor - associated target but hundreds or thousands.
In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.
By tracking and understanding which host cell pathways are manipulated by these T. gondii proteins, scientists can identify potential new targets to develop more effective therapies against highly aggressive solid tumors.
Because the vaccine causes the body to mount an immune response directed against a unique tumor, the therapy is much more effective than gene - targeted or more general chemotherapy alone.
Another possibility that Irvine's lab is working on is developing treatments that could be used against tumors even when scientists don't know of a specific vaccine target for that type of tumor.
«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»
«If our findings are confirmed by additional studies, they may open doors to the development of targeted therapies against the tumor subtypes more likely to affect African Americans and potentially help reduce racial disparities in breast cancer.»
Therapies based on immune cells, which target particular tumor molecules, are more specific, but they are not effective against a variety of tumors.
A T - cell marker panel that can identify subsets of tumor - associated T - cells allows scientists to identify and target subpopulations of T - cells playing unique roles in the immune response against a tumor.
'» In all patients who were vaccinated, his team found tumor - targeting T cells, and he noted that in addition to augmenting pre-existing T cell responses, the vaccine also stimulated new T cell responses against tumors.
Our data suggests that targeting DGKζ could prove to be a more useful clinical approach to augment cytotoxic T cell activity against tumor than targeting Cbl - b, perhaps resulting from enhanced Ras / ERK signaling.
At first, analyzing a patient's surgically removed tumor and developing a vaccine against 10 specific targets on the tumor took nine months, says Greg Lizée, Ph.D., associate professor of Melanoma Medical Oncology, whose research focuses on the immune system.
He said traditional drugs to treat tapeworm infection — which target the whole organism at the larval stage - might not have been effective against tapeworm cancer cells, and it's also unclear whether chemotherapy for normal human cancer cells could have helped shrink the tumors.
Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.
Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.
Researchers publish preclinical data suggesting the promise of a novel drug directed against a novel target n malignant mammary tumors...
«We have created a potentially much less expensive approach to making a therapeutic cancer vaccine that, while targeting a single tumor antigen, generates an immune response against multiple antigens.
Also, CMB305 was well tolerated, and generated a strong and broad anti-NY-ESO-1 immune response in > 50 % of the patients, including evidence of antigen spreading — the induction of an immune response against other tumor antigens not targeted by CMB305.
Stephan's foggy early morning brainwave illuminated an unexpectedly simple approach to making cell - based immunotherapy, in which cancer - targeting immune cells are enlisted to fight tumor cells, as effective against solid tumors as it has been against blood cancers like leukemia.
By exploiting these differences, scientists have developed therapies that target specific tumor types, and these targeted therapies have proven useful against most breast cancers.
«We're using the whole tumor cell, and that allows us to stimulate a response that's broad, that's against multiple targets, and that's against targets that are unique to that individual patient,» Avigan said.
The use of targeting antibodies against vascular endothelial growth factor (VEGF), a protein that promotes tumor growth and spread, plus chemotherapy has prolonged disease free survival in several different tumor types in man.