Sentences with phrase «targeted agents»
"Targeted agents" refer to specific substances or medications that are designed to act against specific targets in the body, such as proteins, molecules, or cells, with the aim of treating or managing certain diseases or conditions. These agents are focused on addressing specific targets rather than affecting the entire body. Full definition
Rather, patients will require a cocktail of targeted agents, perhaps in combinations that change throughout the course of the disease.
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The key is to target agents who are independent and not tied to any single insurance company - that way you can very quickly collect quotes before you buy.
He conducts phase 1 and 2 clinical trials of novel targeted agents.
Identifying your most likely reader — your Right Reader — and then targeting agents and editors that best fit, with a corresponding genre position.
This is just the latest tool to help brokers drive productivity through targeted agent recruiting.
She is an active clinical trialist, leading numerous multiple clinical trials of molecularly targeted agents for advanced cancer patients.
In the recent years, a large number of new molecularly targeted agents have been investigated and are currently under investigation for the treatment of HCC.
The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.
Recently, we have explored immunotherapy combinations with targeted agents as well as combinations of oncolytic viruses with checkpoint inhibitors.
Dr. Aplin and Jessica Teh, PhD, his senior postdoctoral researcher at Jefferson (Philadelphia University + Thomas Jefferson University), examined the effects of a combination of two FDA - approved targeted agents on human melanomas grafted onto mice.
Target agents in specific locations.
We develop cell penetrating peptides and tumor targeting agents based on functionalizable molecular scaffolds with defined distances Zürich or Zurich (/ ˈ zj ʊər ɪ k / ZEWR - ik) is the largest city in Switzerland and the capital of the canton of Zürich.
We develop cell penetrating peptides and tumor targeting agents based on functionalizable molecular scaffolds with defined distances
For a majority of patients diagnosed with aggressive, high - grade tumors with metastases, the five - year survival rate is about 16 percent, though chemotherapy has been associated with an improvement in survival, and new targeted agents are being tested.
Schematic illustration of the developed cancer targeting agent — 123B9 in this study.
FGFR inhibitors are a new family of targeted agents designed to inhibit the action of the fibroblast growth factor receptor, which is often overexpressed in lung, bladder, biliary and breast cancers.
The trial hopes to establish a safe combination of two chemotherapy medications with a stromal targeting agent and is currently recruiting participants.
«We also have data suggesting that this immunotherapy works synergistically with chemotherapy, so testing the effect of this immune targeting agent with chemotherapy was a natural step.»
And they might vary in their ability to enhance or inhibit immune response, because little is known right now about how targeted agents affect the immune system, Sharma said.
«Composition - of - matter and method - of - use patent applications have been filed on these and other additional targeted agents, as well as on the chemistry platform.
VICC Home > Clinical Trials > & nbspMolecular Targeted Agents / Immunotherapy / Biologics Clinical Trials
Despite a possible improvement in median survival of RCC patients treated with VEGF or VEGF - R targeting agents, long - term survivors (> 5 years) are rare.
Although hereditary kidney cancer syndrome accounts for approximately five percent of all kidney cancers, the mechanistic insight into tumor development in these rare conditions has provided the foundation for the development of molecular targeting agents currently used for sporadic...
Although Isis's drug was the first SMN - targeting agent tested in children, RG3039 was actually the first SMN - directed drug discovery program to enter human trials, albeit in a healthy adult population.
Thereby, the binding of relatively weak targeting agents can be enhanced.
Although subscription models work well in certain niche markets, they are backed by publishers who target agented authors instead of independent ones.
Enzon's drug - development programs utilize two platforms: Customized PEGylation Linker Technology (Customized Linker Technology ®) and third - generation mRNA - targeting agents utilizing the Locked Nucleic Acid (LNA) technology.
The recent advances in the understanding of the mechanisms underlying HCC development and progression have allowed molecularly targeted agents to enter the treatment options for HCC.
Awards support development of novel targeted agent, understanding immune system's role in cancer
A. Right now, The Cancer Institute of New Jersey and other institutions are engaged in an approach known as precision / personalized medicine, where systems biologists and other specialists collaborate with scientists and clinicians to identify the molecular alterations associated with cancer, and then tailor regimens of targeted agents to those specific alterations or mutations.
just for the fact that as far as i know none of our targets agents said anything close to this even 10 mins before any announcement.
«Without the targeting agent, paclitaxel can not hitch a ride on EphA2.»
«The siRNA delivery targeted carriers constructed today hone in on specific cells and require chemical conjugation of the targeting agent,» says Prof. Dan Peer of the Laboratory of Precision Nanomedicine at TAU's School of Molecular Cell Biology and Biotechnology, who led the research.
He then studied cancer cell signaling, discovering mechanisms of sensitivity and resistance to targeted agents.
• Because FL118 promotes MdmX degradation through a unique mechanism involving the ubiquitin - proteasomal pathway, it can be used as an MdmX - targeting agent, as well as an inhibitor of anti-apoptotic proteins.
«To the best of our knowledge, this is the first study to present that a targeted agent has promising activity in the management of locally advanced cervical disease.»
Since going on a targeted agent which specifically addresses my genetic mutation, I have felt renewed hope, energy and enthusiasm for life.
Crews noted that RNA splicing - targeted agents have been shown to have activity in a variety of solid tumors so the findings may be relevant to a variety of cancers, such as breast and drug - resistant melanoma.
Furthermore, using the specific molecules on the surface of the cancer blood vessels to target therapeutic agents raises the possibility of using the same molecules to target agents to the cancer cells as well.
Like other members of the MYC family, MYCN has proved very difficult for targeted agents to reach and latch onto, making it, for all intents and purposes, «undruggable.»
Researchers in the Cedars - Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents.
Her research group focuses on diagnostic, prognostic and predictive biomarkers; discovering new therapeutic targets; cancer cells communication via exosomes, microvesicles and CTCs; elucidating and circumventing resistance to targets agents and classical chemotherapy; associations between obesity, metabolic syndrome and cancer.
This includes clinical trials from early pre-clinical phase through phase I / II / III with emphasis on combination of immune and targeted agents, novel drug design, including histology - agnostic trial development of targeted therapies.
Acetylated dendrimers were conjugated to folic acid as a targeting agent and then coupled to either methotrexate or tritium and either fluorescein or 6 - carboxytetramethylrhodamine.
The targeted agent ibrutinib has shown a high response rate in both treatment - naive and previously treated, relapsed, refractory chronic lymphocytic leukemia (CLL) patients older than 65.
The advent of sorafenib has shown that molecularly targeted agents can effectively impact survival in patients with HCC and their side effects can be managed even in patients with cirrhosis.